A5089794335- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Immune cells in cancer
- Obstructive Sleep Apnea Research
- Pluripotent Stem Cells Research
- Cardiac Arrhythmias and Treatments
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- Cardiac Valve Diseases and Treatments
- Ultrasound and Hyperthermia Applications
- Xenotransplantation and immune response
- Neuroscience of respiration and sleep
- Immunotherapy and Immune Responses
- Cardiovascular Disease and Adiposity
- CRISPR and Genetic Engineering
- Renal Transplantation Outcomes and Treatments
- Coronary Interventions and Diagnostics
- Advanced MRI Techniques and Applications
- Diagnosis and Treatment of Venous Diseases
- Colorectal Cancer Surgical Treatments
- Aortic aneurysm repair treatments
- Tracheal and airway disorders
- Venous Thromboembolism Diagnosis and Management
- Cleft Lip and Palate Research
- Dysphagia Assessment and Management
Osaka University
2025
Massachusetts General Hospital
2022-2025
Harvard University
2023-2024
Yamaguchi University
2019-2024
Tokyo National Hospital
2019-2024
Hokkaido University
2014-2023
Tokyo University of Pharmacy and Life Sciences
2022
Saiseikai Shimonoseki General Hospital
2020-2021
Ogori Daiichi General Hospital
2021
Nagoya City University
2015-2017
BEEN IDEN-2][3][4][5][6] In 1992, the American Heart Association concluded that risk of death due to heart disease is increased by about 30% among those exposed environmental tobacco smoke at home, and could be much higher in workplace, where levels may present. 1There evidence exposure nonsmokers breaks down serum antioxidant defenses 7 associated with impairment endotheliumdependent function arterial walls. 8However, acute effects passive smoking on coronary circulation have not been...
Abstract Recent human decedent model studies 1,2 and compassionate xenograft use 3 have explored the promise of porcine organs for transplantation. To proceed to studies, a clinically ready donor must be engineered its successfully tested in nonhuman primates. Here we describe design, creation long-term life-supporting function kidney grafts from genetically transplanted into cynomolgus monkey model. The was carry 69 genomic edits, eliminating glycan antigens, overexpressing transgenes...
This study, by means of a mail survey, quantified the compliance with and side effects use an oral appliance for more than five years in patients snoring or obstructive sleep apnea.A questionnaire was mailed to 544 who used treatment apnea.Some 46.1% returned questionnaire, 37.8% did not, 15% had invalid address, 0.9% were deceased. The mean time period between insertion return date these surveys 5.7 +/- 3.5 years. Of sample, 64.1% wearing their (users). There no significant difference...
Objective: This study aimed to evaluate the effect of inferior mesenteric artery (IMA) embolization during endovascular aneurysm repair (EVAR) in patients at high risk type II endoleak (T2EL) randomized controlled trial (RCT). Summary Background Data: Several studies have demonstrated a reduction T2EL by IMA before EVAR. However, there been no RCT confirming efficacy embolization. Methods: Patients scheduled for elective EVAR between April 2014 and March 2018 were eligible. (IMA patency with...
Bacillibactin (BB) is a microbial siderophore produced by Bacillus species. BB biosynthesized from 2,3‐dihydroxybenzoic acid (2,3‐DHB), Gly, and L‐Thr nonribosomal peptide synthetase (NRPS) enzymes DhbE, DhbB, DhbF. The biosynthetic gene cluster (dhb) also conserved in some strains of thermophilic genera, Geobacillus, Anoxybacillus Parageobacillus. However, the production these bacteria has not been characterized. Here, we report vivo vitro characterization biosynthesis Parageobacillus sp....
<title>Abstract</title> Genetically modified pigs are being developed to address the critical shortage of human organs for transplantation. We have previously demonstrated significantly prolonged survival porcine xenografts devoid three major carbohydrate xenoantigens (3KO) by incorporating transgenes (HTGs). However, optimal HTG combination and mechanisms underlying improved xenograft following such genetic editing remain undefined. In current study, we evaluated, in nonhuman primates,...
This study was carried out to test the hypothesis that changes in head/body position induce upper-airway dimensions. Contiguous images were obtained by means of magnetic resonance imaging normal awake subjects during nasal breathing. A statistical analysis made on 5 consecutive slices, including most constricted sites both retropalatal and retroglossal regions. Dimensional upper airway association with evaluated. In region, there a significant decrease lateral dimension recumbent compared...
Abstract Objective Accelerated atherosclerosis is an important cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Altered coronary microvascular function may act as a marker changes that predispose to the development significant vascular disease. The purpose this study was compare flow reserve (CFR) group premenopausal women SLE age‐, sex‐, race‐matched healthy control subjects. Methods Coronary velocity 18 (mean ± SD age 29.4 5.9 years) 19 matched controls...
Abstract The thymus plays a significant role in establishing immunological self-tolerance. Previous studies have revealed that host immune reaction to allogeneic transplants could be regulated by transplantation. However, physiological involution hinders the clinical application of these insights. Here, we report an efficient generation thymic epithelial-like tissue derived from induced pluripotent stem cells (iPSCs) and its potential regulate We established iPSC line which constitutively...
Hematopoietic stem cell transplantation (HSCT) has many potential applications beyond current standard indications, including treatment of autoimmune disease, gene therapy, and transplant tolerance induction. However, severe myelosuppression other toxicities after myeloablative conditioning regimens have hampered wider clinical use. To achieve donor hematopoietic (HSC) engraftment, it appears essential to establish niches for the HSCs by depleting host HSCs. date, this been achievable only...
Background The cancer stem cell theory proposes that tumor formation in vivo is driven only by specific tumor-initiating cells having stemness; however, clinical trials conducted to test drugs target the stemness provided unsatisfactory results thus far. Recent studies showed clear involvement of immunity tumors; requirements tumor-initiation followed stable growth immunocompetent individuals remain largely unknown. Methods To clarify this, we used two similarly induced glioblastoma lines,...
Ovarian cancer is the second-most lethal gynecological malignancy and seventh-commonest cause of cancer-related death in women around world. Most ovarian patients are diagnosed at advanced stages suffer from recurrence after primary cytoreductive surgery standard first-line chemotherapy. Thus, successful management requires identification factors that contribute to progression relapse. Interleukin-34 (IL-34) a novel cytokine acts as tissue-specific ligand colony-stimulating factor-1 receptor...