A5091774257- Immune cells in cancer
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Nanoparticle-Based Drug Delivery
- Inflammation biomarkers and pathways
- RNA modifications and cancer
- Pluripotent Stem Cells Research
- Cancer Research and Treatments
- CRISPR and Genetic Engineering
- Cytokine Signaling Pathways and Interactions
- Immune Response and Inflammation
- Galectins and Cancer Biology
- Macrophage Migration Inhibitory Factor
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Ferroptosis and cancer prognosis
- Phagocytosis and Immune Regulation
- CAR-T cell therapy research
- Cancer Cells and Metastasis
- Peptidase Inhibition and Analysis
- Chemokine receptors and signaling
- Pancreatic and Hepatic Oncology Research
- T-cell and B-cell Immunology
- Reproductive System and Pregnancy
Usmanu Danfodiyo University
2024
Hokkaido University
2012-2021
Kumamoto University
2014
Juntendo University
2011
The ability of tumor cells to escape immune destruction and their acquired resistance chemotherapy are major obstacles effective cancer therapy. Although checkpoint therapies such as anti-PD-1 address these issues in part, clinical responses remain limited a subpopulation patients. In this report, we identified IL34 produced by driver chemoresistance. particular, found that modulated the functions tumor-associated macrophages enhance local immunosuppression promote survival chemoresistant...
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic malignancies. PDAC builds a tumor microenvironment that plays critical roles in progression and metastasis. However, relationship between chemotherapy modulation PDAC-induced remains poorly understood. In this study, we report role chemotherapy-derived inflammatory response enrichment with immunosuppressive myeloid cells. Granulocyte macrophage colony-stimulating factor (GM-CSF) major cytokine associated oncogenic...
Phagocytosis of apoptotic cells by myeloid has been implicated in the maintenance immune homeostasis. In this study, we found that T cell immunoglobulin- and mucin domain-containing molecule-4 (TIM-4) repressed tumor-specific immunity triggered chemotherapy-induced tumor death. TIM-4 was to be highly expressed on tumor-associated such as macrophages (TAMs) dendritic (TADCs) danger-associated molecular patterns (DAMPs) released from chemotherapy-damaged induced recruited bone marrow-derived...
Despite recent advances in diagnosis and treatment of lung cancers, the 5-year survival rate remains unsatisfactory, which necessitates identification novel factors that associates with disease progression malignant degree for improving diagnostic therapeutic strategies. Recent progress cancer immunology research has unveiled critical roles colony stimulating factor 1 receptor (CSF1R) multiple aspects tumor microenvironment. CSF1R is expressed on tumor-associated macrophages (TAMs), mediates...
Resistance to anticancer therapeutics greatly affects the phenotypic and functional properties of tumor cells, but how chemoresistance contributes tumorigenic activities cancer stem-like cells remains unclear. In this study, we found that a characteristic from chemoresistant tumors (CSC-R) is ability produce variety proinflammatory cytokines generate M2-like immunoregulatory myeloid CD14(+) monocytes. Furthermore, identified IFN-regulated transcription factor IRF5 as CSC-R-specific critical...
Significance A unique characteristic of invariant natural killer T ( i NKT) cells is their ability to immediately produce large amounts interferon-gamma (IFN-γ) upon activation, which enables these play critical roles in initiating immune responses various pathological conditions. In this study, we demonstrate a previously unidentified mechanism mediated by basic helix–loop–helix transcription factor family, member e40 (Bhlhe40) for accelerating IFN-γ production NKT cells. Bhlhe40 required...
Immunotherapies that target immune-checkpoint molecules such PD-1 have helped to achieve durable responses in melanoma treatment. However, 25% of patients who showed objective blockade develop resistance and suffer from disease progression ultimately death, which necessitates the identification related mechanisms.IL-34 is a cytokine controls biology myeloid cell lineage through binding CSF-1R. IL-34 importantly involved pathogenesis various diseases. In cancer, expression has been suggested...
Abstract The thymus plays a significant role in establishing immunological self-tolerance. Previous studies have revealed that host immune reaction to allogeneic transplants could be regulated by transplantation. However, physiological involution hinders the clinical application of these insights. Here, we report an efficient generation thymic epithelial-like tissue derived from induced pluripotent stem cells (iPSCs) and its potential regulate We established iPSC line which constitutively...
Ovarian cancer is the second-most lethal gynecological malignancy and seventh-commonest cause of cancer-related death in women around world. Most ovarian patients are diagnosed at advanced stages suffer from recurrence after primary cytoreductive surgery standard first-line chemotherapy. Thus, successful management requires identification factors that contribute to progression relapse. Interleukin-34 (IL-34) a novel cytokine acts as tissue-specific ligand colony-stimulating factor-1 receptor...
Abstract Multiple myeloma (MM) is a hematological malignancy that grows in multiple sites of the axial skeleton and causes debilitating osteolytic disease. Interleukin-34 (IL-34) newly discovered cytokine acts as ligand colony-stimulating factor-1 (CSF-1) receptor can replace CSF-1 for osteoclast differentiation. In this study, we identify IL-34 an osteoclastogenic accelerates disease MM. was found to be expressed murine MM cell line MOPC315.BM, expression enhanced by stimulation with...
Induced pluripotent stem cell (iPSC) technology provides new opportunities in regenerative medicine to generate grafts from donors for transplantation. However, particularly when allogeneic iPSCs are used, immune suppression is required avoid rejection of iPSC-derived grafts. In this study, we examine a concept that protection iPSCs-derived allografts can be achieved transplantation accompanied with the administration immunosuppressive cells generated same resource.Mouse were differentiated...
Interleukin-34 (IL-34) is an alternative ligand to colony-stimulating factor-1 (CSF-1) for the CSF-1 receptor that acts as a key regulator of monocyte/macrophage lineage. In this study, we show tumor-derived IL-34 mediates resistance immune checkpoint blockade regardless existence in various murine cancer models. Consistent with its immunosuppressive characteristics, expression tumors correlates decreased frequencies cellular (such CD8+ and CD4+ T cells M1-biased macrophages) molecular...
Measles is the leading cause of vaccine-preventable childhood disease in developing countries, with highest incidence among children under 5 years age. The emergence and recurrence measles as an infectious affects high-risk groups number cases deaths increases rapidly. Before idea vaccination was introduced, more than 2 million people died each year. most common areas where there little or no vaccination coverage, especially limited resources such Africa Nigeria. Although a disease, it...
The mortality of colorectal cancer is expected to increase in some countries including the United States, which necessitates identification new molecules that help prognosis assessment and survival improvement. In this brief report, we evaluated potential interleukin-34 (IL-34) as a prognostic factor cancer. IL-34 was reported for first time 2008 novel cytokine controls biology myeloid cell lineage. Accumulating evidence suggests important roles modifying tumor microenvironment enhancing...
Although the tumor microenvironment plays a critical role in progression and metastasis, relationship between chemotherapy resistance modulation of remains unclear. Here, we report novel mechanism showing how constitutive DNA damage signals therapy-resistant cells suppress antitumor immunity an integrin-αvβ3-dependent manner. Integrin-αvβ3 was upregulated on various through chronic activation ATM/Chk2-and NFκB-mediated pathways. Inhibiting tumor-specific expression integrin-αvβ3 improved...
Dendritic cells (DC) manipulate tissue homeostasis by recognizing dying and controlling immune functions. However, the precise mechanisms which DC recognize different types of devise distinct immunologic consequences remain largely obscure. Herein, we demonstrate that Milk-fat globule-EGF VIII (MFG-E8) is a critical mediator immunogenicity in inflammatory microenvironments. MFG-E8 restrains DC-mediated uptake recognition necrotic cells. The MFG-E8-mediated suppression cell resulted decreased...
The c-fms proto-oncogene is also known as macrophage colony stimulating factor receptor (M-CSFR) or colony-stimulating factor-1 (CSF-1R), and expressed on several types of malignant tumor cells myeloid cells. In the present study, we found that overexpression M-CSFR was in adult T-cell leukemia/lymphoma (ATLL) cases. signaling associated with lymphoma cell proliferation, inhibition induced apoptosis ATLL line ATL-T M-CSF/CSF-1 interleukin (IL)-34, which are both ligands. M-CSF IL-34...