A5090382073- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Surgical Simulation and Training
- Neuroendocrine Tumor Research Advances
- Gastrointestinal Tumor Research and Treatment
- Cancer Research and Treatments
- Immune cells in cancer
- Metastasis and carcinoma case studies
- Cancer Immunotherapy and Biomarkers
- Anatomy and Medical Technology
- Virus-based gene therapy research
- Colorectal Cancer Surgical Treatments
- Pancreatitis Pathology and Treatment
- Immunotherapy and Immune Responses
- Nanoparticle-Based Drug Delivery
- Cancer Genomics and Diagnostics
- Cancer Mechanisms and Therapy
- Viral-associated cancers and disorders
- Gastrointestinal disorders and treatments
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
Hokkaido University Hospital
2013-2025
Hokkaido University
2016-2025
Japan Surgical Society
2022-2023
Jikei University School of Medicine
2021
Creative Commons
2016-2018
Tonan Hospital
1998-2016
Soka Municipal Hospital
2016
Japan Space Forum
2016
American Gastroenterological Association
2015
McGill University
2014
To analyze the long-term results of distal pancreatectomy with en bloc celiac axis resection (DP-CAR), a newly designed extended surgical procedure for locally advanced cancer pancreatic body.Pancreatic body often involves common hepatic artery and/or and is regarded as an unresectable disease. We previously reported feasibility safety DP-CAR in 10 patients 3 preliminary cases; however, are unknown.Between May 1998 September 2005, 23 underwent DP-CAR. No reconstruction arterial system was...
Notch signaling dictates cell fate and critically influences proliferation, differentiation, apoptosis in metazoans. Ligand binding initiates the signal through regulated intramembrane proteolysis of a transmembrane receptor which releases signal-transducing intracellular domain (NICD). The HES/E(spl) gene family is primary target thus far only known effector. A newly isolated HERP family, HES-related basic helix-loop-helix protein has been proposed as potential Notch, based on its induction...
Radical resection for hilar cholangiocarcinoma is still associated with significant morbidity and mortality. The aim of this study was to analyze short-term surgical outcomes validate our strategies, including preoperative management selection operative procedure.We surgically treated 146 consecutive patients a strategy consisting biliary drainage, portal vein embolization, procedure based on tumor extension hepatic reserve. Major hepatectomy conducted in 126 patients, caudate lobectomy or...
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic malignancies. PDAC builds a tumor microenvironment that plays critical roles in progression and metastasis. However, relationship between chemotherapy modulation PDAC-induced remains poorly understood. In this study, we report role chemotherapy-derived inflammatory response enrichment with immunosuppressive myeloid cells. Granulocyte macrophage colony-stimulating factor (GM-CSF) major cytokine associated oncogenic...
Caveolin-1 is a major component of caveolae and plays regulatory role in several signalling pathways. was recently identified as metastasis-related gene prostate cancer. The clinical effects caveolin-1 expression pancreatic carcinoma, however, remain unknown. In this study, we have investigated the relationship between clinicopathologic variables outcome 79 patients with adenocarcinoma undergoing surgical resection. determined by immunohistochemistry, using polyclonal anti-caveolin-1...
Pigment epithelium-derived factor (PEDF) is expressed in several normal organs and identified as an inhibitor of neovascularization. In the present study, we screened expression PEDF immunohistochemically investigated its correlation with clinicopathological features patients who underwent surgery for ductal pancreatic adenocarcinoma. Of 80 patients, 22 cases (27.5%) were positive PEDF. A significant association was found between low microvessel density (P = 0.0003). No age, gender, depth...
Abstract Due to advances in endoscopic equipment and techniques, preoperative biliary drainage (EBD) has been developed serve as an alternative percutaneous transhepatic (PTBD). This study sought clarify the benefit of EBD comparison PTBD patients who underwent radical resections hilar cholangiocarcinoma. One hundred forty‐one surgery for cholangiocarcinoma between 2000 2008 were retrospectively divided into two groups based on type drainage, ( n = 67) or 74). We investigated if different...
Abstract Background Identification of lymph node metastases in biliary cancer is important for determining prognosis and surgical planning, but the effectiveness computed tomography (CT) diagnosing hepatoduodenal ligament (peribiliary retroportal nodes) or around common hepatic artery unknown. Methods CT scans pathological results from 146 patients who had undergone regional lymphadenectomy carcinoma were reviewed. To evaluate nodes, long- short-axis diameters nodes measured axial ratios...
The high frequency of surgical site infections (SSIs) after hepato-pancreato-biliary (HPB) surgery is a problem that needs to be addressed. This prospective, randomized, controlled study examined whether perioperative prophylactic use antibiotics based on preoperative bile culture results in HPB could decrease SSI.Participants comprised 126 patients who underwent (bile duct, gallbladder, ampullary, or pancreatic) cancer with biliary reconstruction at Hokkaido University Hospital between...
Abstract The efficacy of preoperative neoadjuvant chemoradiotherapy ( NAC ) in cases pancreatic cancer with extremely poor prognoses has been reported. In this study, we aimed to identify novel biomarkers that reflect following using tertiary lymphoid organs TLO expressed the tumor microenvironment. Resected specimens were obtained from 140 patients. We retrospectively investigated clinical relevance by categorizing patients into those who underwent upfront surgery (surgery first [ SF ]) and...
Introduction: Although neuroendocrine neoplasms (NENs) have a good prognosis, distant metastasis remains crucial prognostic factor. Survivin, tumor-associated antigen, is overexpressed in several solid tumors, indicating poor prognosis. We aimed to evaluate the clinical significance and role of survivin as therapeutic target for NEN. Methods: assessed cytotoxicity Survivin-2B (a splicing variant Survivin) 80-88 specific CTL clone with HLA-A24 restriction against NEN cell lines using...
Background: Determining the optimal resection line for an organ that cannot be palpated is crucial, but challenging, in minimally invasive gastrointestinal (GI) surgery. Therefore, there urgent need to establish most effective method tumor localization. We hypothesize our novel near-infrared (NIR) fluorescence detection system will enable highly accurate of fluorescent clips marking GI cancer. Methods: Twenty-five patients with gastric cancer, esophagogastric junctional or esophageal cancer...
The Olympus bronchoscope is equipped with an insertion tube rotation function; however, data on its usefulness are currently limited. Here, we evaluated the amount of body and wrist movement required by bronchoscopists, operability bronchoscope, ease use without function. This study was performed 10 bronchoscopists using 2 cadaveric bodies. primary endpoint exerted bronchoscopist, which motion capture. We also assessed deepest bronchial generations that could be reached time for insertion....
Tumor-infiltrating lymphocytes form an important aspect of the host defense against expanding neoplasm. CD8+ T cells have been identified as a prognostic factor in several cancers. Here, we investigate that influence on extrahepatic bile duct carcinoma (EBDC) patient survival.CD8+ cell immunoreactivity 58 surgically resected EBDC specimens was investigated. The relationship between and clinical histopathologic features analyzed.Thirty-two tumors (55%) possessed intratumoral cells. degree...
CD4/8 status has been previously reported to be a critical factor in the prognosis of oesophageal squamous cell carcinoma (OSCC). In current study, we investigated effect regulatory T cells (Treg; Foxp3+ lymphocytes) on CD4+ and CD8+ 122 patients with OSCC. Immunohistochemical analysis Treg was performed using an antibody against Foxp3. The survival rate for low Foxp3 significantly lower than high (P=0.0028 by log-rank test), but did not correlate CD4/8(+/+) or CD4/8(+/-) (-/+) (P=0.5185...