A5101901482- Orthopaedic implants and arthroplasty
- Liver Disease Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Immunotherapy and Immune Responses
- Gastric Cancer Management and Outcomes
- Monoclonal and Polyclonal Antibodies Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Gout, Hyperuricemia, Uric Acid
- Advanced Synthetic Organic Chemistry
- Hip disorders and treatments
- Synthetic Organic Chemistry Methods
- Total Knee Arthroplasty Outcomes
- Nitric Oxide and Endothelin Effects
- Asymmetric Synthesis and Catalysis
- Osteoarthritis Treatment and Mechanisms
- Genetic Mapping and Diversity in Plants and Animals
- RNA Interference and Gene Delivery
- Shoulder Injury and Treatment
- Alcohol Consumption and Health Effects
- Shoulder and Clavicle Injuries
- Sarcoma Diagnosis and Treatment
- IgG4-Related and Inflammatory Diseases
- Helicobacter pylori-related gastroenterology studies
- Blood Coagulation and Thrombosis Mechanisms
Japan International Research Center for Agricultural Sciences
2024
Kitasato University
2021-2024
National Hospital Organization
2014-2024
Iwate Prefectural Central Hospital
2024
Hoshi University
2023
Hokkaido University
2015-2022
University of Tokyo Hospital
2020-2022
Sapporo Holdings (Japan)
2020-2022
Josai University
2022
University Medical Center Hamburg-Eppendorf
2020
We had reported that the systemic administration of N omega-methyl-L-arginine (L-NMA), a specific inhibitor nitric oxide (NO) synthesis from L-arginine (ARG), raises arterial blood pressure (BP) while paradoxically enhancing central sympathetic outflow. Cervical spinal cord transection abolishes increase in outflow and attenuates pressor effect L-NMA. Thus, addition to lowering BP by direct vasorelaxation, NO may also act nervous system reduce vascular tone. To test this hypothesis we have...
Oncostatin M (OSM) is a member of the IL-6 family cytokines. Mice deficient in OSM receptor (OSMR -/- ) showed impaired liver regeneration with persistent parenchymal necrosis after carbon tetrachloride (CCl 4 exposure. The recovery mass from partial hepatectomy was also significantly delayed OSMR mice. In contrast to wildtype mice, CCl administration only marginally induced expression tissue inhibitor metalloproteinase (TIMP)-1 and TIMP-2 genes correlating increased gelatinase activity...
Protein S is a vitamin K dependent protein whose inherited deficiency well recognized risk factor for venous thrombosis. Its role to act as activated C cofactor in Va and VIIIa proteolysis, thus restricting thrombin generation. gene lies on chromosome 3, at position 3p11.1-q11.2, its structural organization has been described. Elucidation of the defects responsible proceeding rapidly. A first record identified mutations was undertaken 1996 under auspices International Society Thrombosis...
Background: Helicobacter pylori eradication rates achieved with a first-line regimen of clarithromycin (CLR) combined amoxicillin (AMX) and proton pump inhibitor have recently fallen to ≤80% because the increasing incidence CLR resistance in Japan. This randomized multicenter trial aimed compare success 2 triple therapy regimens: rabeprazole, amoxicillin, (RAC) versus metronidazole (RAM). Methods: A total 124 consecutive patients infected H. were into one two 7-day therapeutic RAC (n=60) or...
To evaluate the influence of cortical and cancellous bone structure on biomechanical properties all-suture conventional anchors compare morphological damage after their failure. The hypothesis study is that anchor pullout less invasive force influenced by thickness.Thirty human humeri were biomechanically tested as follows: starting with a load cycle from 20 to 50 N, stepwise increase upper peak 0.05 N for each at rate 1 Hz was performed. Analysis included maximum strength three different...
The beneficial effects of fatty acids (FAs) on human health have attracted widespread interest. However, little is known about the impact FAs handling urate, end-product purine metabolism, in body. Increased serum urate levels occur hyperuricemia, a disease that can lead to gout. In humans, filtered by glomerulus kidney majorly re-absorbed from primary urine into blood via transporter 1 (URAT1)-mediated pathway. URAT1 inhibition, thus, contributes decreasing concentration increasing net...
Hyperuricemia, a lifestyle-related disease characterized by elevated serum urate levels, is the main risk factor for gout; therefore, urate-lowering effects of human diets or dietary ingredients have attracted widespread interest. As Urate transporter 1 (URAT1) governs most reabsorption from primary urine into blood, URAT1 inhibition helps decrease levels increasing net renal excretion. In this study, we used cell-based transport assay to investigate URAT1-inhibitory 162 extracts plant...
Background: The efficacy of systemic chemotherapy against peritoneal dissemination from advanced gastric cancer (AGC) remains unclear, because the was not defined as a measurable lesion in conventional phase II studies. In this study, we evaluated and toxicity sequential MTX 5FU therapy (MF) chemotherapy-naive patients with AGC accompanied by malignant ascites setting.
Osteoarthritis (OA) is a chronic degenerative musculoskeletal disease that causes articular cartilage degeneration and pain. Research into OA animal models suggests elevated NGF levels in the synovium contribute to pain central sensitization (CS). However, it unclear whether synovial contributes CS patients with OA. We investigated association between expression clinical assessments of hip (hOA) patients. also aimed identify which cells hOA express NGF. Sixty-six who received total...
Black soybeans have been used as a food source and also in traditional medicine because their seed coats contain natural phenolic compounds such proanthocyanidin anthocyanin. The objective of this research is to reveal the genetic variation compound contents (PCCs) 227 black soybean cultivars, most which were Japanese landraces cultivars. Total phenolics extracted from using an acidic acetone reagent content, monomeric anthocyanin total flavonoids radical scavenging activity measured....
Summary Background : Helicobacter pylori resistance to clarithromycin, probably due the frequent use of this antibiotic for treatment other diseases, is greatest obstacle against its eradication. Aim To clarify prevalence clarithromycin‐resistant H. in patients with non‐tuberculous mycobacterial lung disease receiving multiple treatment, including clarithromycin. Methods We enrolled 88 disease; 29 underwent upper gastrointestinal endoscopy diagnosis infection prior and 60 it during...
Summary A case of congenital combined deficiency factor V and VIII was reported. The patient, a 9 year old boy, gave history epistaxis, hematomas, hemorrhages following dental extraction since the age 2 ; plasma levels were found to be 16% 8% normal, respectively. No one in his family had either factor. effects transfusion normal fresh whole blood from patient with hemophilia studied. While former similar pattern as seen classical hemophilia, latter consisted an immediate increase activity...
A method for the synthesis of 3-methylene-1,4-cycloheptadiene derivatives via an 8π electrocyclization reaction was developed. The triene substrate bearing a phosphate or carbamate group prepared from γ,δ-unsaturated esters and α,β-unsaturated aldehydes in four steps. Upon treatment with NaHMDS KHMDS, formed heptatrienyl anion, which underwent subsequent β-elimination leaving group. product could be converted into tropylium salt two
The present study prepared inclusion complexes of S-allylcysteine (SAC) and cyclodextrin (α, β, γ) by the freeze-drying (FD) method verified behavior solid dispersion. Also, investigated effect SAC/CD complex formation on liver tumor cells. Isothermal titration calorimetry (ITC) measurements confirmed exothermic curve for SAC/αCD, suggesting a molar ratio SAC/αCD = 1/1, but no exothermic/endothermic reaction was obtained SAC/βCD SAC/γCD system. Powder X-ray diffraction (PXRD) results showed...
A new synthetic strategy that forms a seven-membered carbocycle using an anionic 8π electrocyclic reaction facilitated the first total synthesis of 6,11-epoxyisodaucane natural sesquiterpene in 9.0% yield over 10 steps longest linear sequence. The misassigned proposed stereochemistry was corrected by both structure and its C6 epimer. In addition, 5-7-fused ring system concisely constructed tandem decyanation/five-membered-ring formation from epoxynitrile.