A5005176846- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Metastasis and carcinoma case studies
- Gastrointestinal disorders and treatments
- Esophageal and GI Pathology
- Inflammatory Bowel Disease
- Esophageal Cancer Research and Treatment
- Gastroesophageal reflux and treatments
- Genetic factors in colorectal cancer
- Lymphoma Diagnosis and Treatment
- Microscopic Colitis
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Eosinophilic Esophagitis
- Colorectal Cancer Screening and Detection
- Autoimmune and Inflammatory Disorders
- Clostridium difficile and Clostridium perfringens research
- Colorectal Cancer Treatments and Studies
- Gallbladder and Bile Duct Disorders
- Abdominal vascular conditions and treatments
- Cancer Genomics and Diagnostics
- Multiple and Secondary Primary Cancers
- Gastrointestinal Bleeding Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
National Hospital Organization
2016-2025
Fukuyama Cardiovascular Hospital
2016-2025
Fukuyama University
2012-2024
Kagawa Prefectural Central Hospital
2024
Mito Saiseikai General Hospital
1997-2013
Okayama University
1997-2008
Abstract Background and Aim: Endoscopic submucosal dissection (ESD) is a useful procedure for the treatment of early gastric neoplasms; however, this advanced technique has also resulted in an increase serious complications such as perforation delayed bleeding. This study aimed to elucidate risk factors these complications. Methods: A total 1123 lesions diagnosed with neoplasms treated by ESD at three institutions were investigated. Retrospectively, patients or without compared on basis...
Summary Background Although Helicobacter pylori infection is closely associated with gastric cancer development, follow‐up studies after H. eradication are still scarce. Aim To clarify the preventive effect of eradication, special attention to differences in according histology. Methods Patients who underwent therapy and were followed‐up endoscopically for at least 1 year analysed. The incidence factors development investigated. Results A total 1807 patients enrolled. Six 1519 eradicated...
To analyze the clinical characteristics of patients with gastrointestinal bezoars and their response to therapy. Patients We retrospectively reviewed cases 19 diagnosed at Okayama University Graduate School Medicine, Dentistry Pharmaceutical Sciences or one 15 collaborating institutions between December 2004 August 2013. investigated epidemiology etiology by determining gender, age diagnosis, medical history, symptoms, complications, modalities used for treatments, outcomes bezoar location,...
Background: Helicobacter pylori eradication rates achieved with a first-line regimen of clarithromycin (CLR) combined amoxicillin (AMX) and proton pump inhibitor have recently fallen to ≤80% because the increasing incidence CLR resistance in Japan. This randomized multicenter trial aimed compare success 2 triple therapy regimens: rabeprazole, amoxicillin, (RAC) versus metronidazole (RAM). Methods: A total 124 consecutive patients infected H. were into one two 7-day therapeutic RAC (n=60) or...
Contact between Helicobacter pylori and gastric epithelial cells results in activation of NF-κB followed by secretion interleukin (IL)-8. However, host-cell receptor(s) their ligands involved H. pylori-related IL-8 production have yet to be fully defined. In this study, the interaction Toll-like receptors (TLRs), which are host for pathogens innate immune response, heat-shock protein (HSP) 60, an immune-potent antigen pylori, was examined during pylori-induced vitro. Recombinant HSP60...
It still remains controversial whether gastric mucosal atrophy and intestinal metaplasia are reversible after eradication of Helicobacter pylori infection. The aims this study were to evaluate the histological changes in mucosa H. during long-term follow-up periods, verify propriety for elderly population.Two hundred forty-one patients with infection 84 cases more than 60 years old classified as group. mean period was 101 months. A series endoscopic examinations five-point biopsies performed...
Background and aims Endoscopic mucosal resection (EMR) is a standard preventive method for colorectal cancer. Managing patients on anticoagulants during EMR challenging because of balancing bleeding thrombotic risks. Updated guidelines recommend continuing over heparin bridging; however, data risks with remain limited. This multicenter prospective study evaluated rates in who continued oral EMR. Methods Patients warfarin or direct (DOACs) undergoing were enrolled from 12 tertiary hospitals....
Background: Bleeding is a serious and frequent adverse event that occurs during after endoscopic papillectomy (EP). Previous studies have highlighted the effectiveness of preventive clipping closure resection site in preventing post-EP bleeding. However, optimal length remained unclear. Objectives: We aimed to clarify at prevent delayed Design: This study was multicenter retrospective cohort study. Methods: retrospectively analyzed patients who were consecutively admitted nine high-volume...
Abstract Background and Aim Although oral mesalamine is the first‐choice drug for treating mild‐to‐moderate ulcerative colitis (UC), some patients show symptoms of intolerance, including exacerbation diarrhea abdominal pain. The present study clarified current state clinical courses with intolerance. Methods Patients who were diagnosed UC administered at eight hospitals in Japan a follow‐up period exceeding 1 year analyzed. Results Sixty‐seven (11%) 633 showed intolerance to least one...
Abstract Background The endoscopic features of oxyntic gland adenoma and gastric adenocarcinoma the fundic type have not been fully investigated in relation to Helicobacter pylori infection status. We compared morphology, color, location these lesions between patients with without H. infection. Methods retrospectively enrolled 165 (180 lesions) from 10 institutions. divided into (i) Hp group (patients current [active gastritis, n = 13] those past [inactive 76]) (ii) uninfected ( -uninfected...
Patients with primary intestinal follicular lymphoma are often followed-up without a specific treatment, and this approach is called the "watch-and-wait approach." However, long-term outcomes of patient group have not been sufficiently investigated. We enrolled patients who were diagnosed before 2016 managed watch-and-wait in 20 institutions. retrospectively investigated overall, disease-specific, event-free survival rates as well rate spontaneous regression. Among 248 gastrointestinal...
Eur J Clin Invest 2011; 41 (5): 474–478 Abstract Background Endoscopic submucosal dissection (ESD) is a standard treatment in Japan for early gastric neoplasms. With an increase elderly population, the number of patients whom ESD performed has also steadily increased. Aims and methods The aim study was to evaluate effectiveness problems associated with neoplasms patients. Subjects were 514 (586 lesions) at two institutions. classified into group (age ≥ 75 years) nonelderly < years). We...
Although the frequency of residual disease and recurrence following endoscopic submucosal dissection (ESD) has markedly decreased, a few cases ESD are still observed. The aims present study were to clarify causes non-curative resection investigate risk factors. A total 1,123 early gastric neoplasm lesions treated by investigated. Non-curative was defined as histological positivity resected margins, vascular invasion or failure en bloc resection. Cases classified being caused one three...
Abstract The aim of this study was to reveal the histological features oxyntic gland adenomas and gastric adenocarcinoma fundic-gland type (GA-FG). We retrospectively examined 126 lesions adenoma and/or GA-FG in 116 patients. prevalence approximately equal. majority were resected by endoscopic mucosal resection using a diathermic snare (EMR, n = 42) or submucosal dissection (ESD, 72). Histologically, there no with invasion at level muscularis propria deeper, lymphovascular present 1.6%. Of...
A low platelet count leads to dose reduction of interferon (IFN) and is associated with failure achieve a sustained virological response (SVR) in chronic hepatitis C patients. However, partial splenic embolization (PSE) effective for treating thrombocytopenia resulting from hypersplenism. We compared the clinical features 10 patients receiving PSE prior combination therapy IFN ribavirin (RBV) (PSE group) those non-receiving (non-PSE group). In all patients, was successfully performed without...
Background/Aims: Delayed bleeding is among the adverse events associated with therapeutic gastrointestinal endoscopy. The aim of this study was to evaluate risk factors for delayed after endoscopic resection in patients receiving oral anticoagulants as well compare rates occurrence between used. Methods: We retrospectively analyzed a total 772 anticoagulants. Of these, 389 and 383 were direct (DOACs) warfarin, respectively. Therapeutic procedures performed included submucosal dissection...
Abstract Gastric emphysema is characterized by the presence of intramural gas in stomach without bacterial infection. Due to its rarity, most reports on gastric have been limited single-case studies, and this condition’s clinical endoscopic features not thoroughly investigated. In study, we analyzed 45 patients with from 10 institutions examined their characteristics, features, outcomes. The mean age at diagnosis our study population (35 males females) was 68.6 years (range, 14–95 years)....
Clinical characteristics and prognosis of patients with a solitary Peutz-Jeghers polyp (PJP) have not been fully investigated.Solitary PJP was diagnosed when single hamartomatous lesion identified in the gastrointestinal tract without mucocutaneous pigmentation or family history syndrome. We retrospectively reviewed 51 (32 men 19 women) analyzed sex, age at diagnosis, endoscopic features, outcomes this patient group. The STK11/LKB1 germline mutation investigated any patients.The mean 66.1...
Background/Aims: The prevalence of reflux esophagitis, which might lead to development Barrett’s esophagus and esophageal adenocarcinoma, has been increasing. aim this study was assess risk factors for esophagitis. Methods: We conducted a cross-sectional 1,495 Japanese subjects undergoing health checkups (822 males 673 females; median age 50 years) at tertiary care center. Results: One hundred twenty-seven (8%) had esophagitis hiatal hernia observed in 292 (20%). Reflux (13 vs. 3%) (28 9%)...
The efficacy of gemcitabine (GEM) on unresectable pancreatic cancer has been reported. However, in elderly patients, severe toxicities are frequently observed. In this study we aimed to assess the low-dose GEM patients.We reviewed 68 patients (≥65 years) with cancer. Thirty-six were treated (600-800 mg/m(2); group), and other 32 received best supportive care (BSC group).Median survival was 7.6 2.3 months BSC groups, respectively. group, median period longer 24 showing partial response or...