Takashi Kagaya
A5028587571- Inflammatory Bowel Disease
- COVID-19 Clinical Research Studies
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Cytomegalovirus and herpesvirus research
- Gastrointestinal Bleeding Diagnosis and Treatment
- Hepatitis B Virus Studies
- Gastrointestinal disorders and treatments
- Virus-based gene therapy research
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Immunodeficiency and Autoimmune Disorders
- Diabetes and associated disorders
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Hepatitis C virus research
- Drug-Induced Hepatotoxicity and Protection
- IgG4-Related and Inflammatory Diseases
- Gastrointestinal Tumor Research and Treatment
- Pancreatitis Pathology and Treatment
- Cancer Diagnosis and Treatment
- Herpesvirus Infections and Treatments
- Liver Diseases and Immunity
- Long-Term Effects of COVID-19
National Hospital Organization
2016-2025
Kanazawa Medical Center
2016-2025
Agaplesion Markus Hospital
2023
Goethe University Frankfurt
2023
Fukujuji Hospital
2022
National Center for Geriatrics and Gerontology
2020
Kanazawa University
2001-2019
Kanazawa University Hospital
2010-2017
The inflammatory bowel disease ulcerative colitis (UC) frequently progresses to colon cancer. To understand the mechanisms by which UC patients develop carcinomas, we used a mouse model of whereby administration azoxymethane (AOM) followed repeated dextran sulfate sodium (DSS) ingestion causes severe colonic inflammation and subsequent development multiple tumors. We found that treating WT mice with AOM DSS increased TNF-alpha expression number infiltrating leukocytes expressing its major...
Radiofrequency ablation (RFA) is one of the treatments for hepatocellular carcinoma (HCC) and known to enhance host immune response. However, epitopes which enhanced responses occur, impact on patient prognosis, functions phenotype T cells induced are still unclear. To address these issues, we analyzed before after RFA in 69 HCC patients using 11 tumor-associated antigen (TAA)-derived peptides that identified be appropriate analyze HCC-specific responses. The were enzyme-linked immunospot...
The QUASAR Phase 2b Induction Study evaluated the efficacy and safety of guselkumab, an interleukin-23p19 subunit antagonist, in patients with moderately to severely active ulcerative colitis (UC) prior inadequate response and/or intolerance corticosteroids, immunosuppressants, advanced therapy.
Many tumor-associated antigens (TAAs) recognized by cytotoxic T cells (CTLs) have been identified during the last two decades and some of them used in clinical trials. However, there are very few field immunotherapy for hepatocellular carcinoma (HCC) because not comparative data regarding CTL responses to various TAAs. In present study, using 27 peptides derived from 14 different TAAs, we performed analysis TAA-specific T-cell 31 HCC patients select useful examined factors that affect immune...
Recent metagenomic analyses have revealed dysbiosis of the gut microbiota ulcerative colitis (UC) patients. However, impacts this are not fully understood, particularly at strain level.We perform whole-genome shotgun sequencing fecal DNA extracts from 13 healthy donors and 16 UC 8 Crohn's disease (CD) The CD patients is taxonomically functionally divergent that donors, with E. faecium being most differentially abundant species between two microbial communities. Transplantation feces or into...
Inflammation plays a critical role in cancer. The aim of the present study was to investigate impact neutrophil lymphocyte ratio (NLR) on patients with advanced hepatocellular carcinoma (HCC) treated hepatic arterial infusion chemotherapy (HAIC).We retrospectively evaluated 266 HCC HAIC between March 2003 and December 2012. NLR calculated from differential leukocyte count by dividing absolute count.The cut-off level set as median value 2.87 among all this study. objective response rate low...
Background & AimsWe previously reported results from a prospective randomized controlled trial comparing the efficacy of adalimumab monotherapy versus combination with azathioprine for patients Crohn's disease (CD) who were naive to biologics and thiopurines. We performed subanalysis data this study evaluate factors associated endoscopic response mucosal healing in participants.MethodsWe compared simple scores CD between moderate severe active randomly assigned groups that received (n = 85)...
Although cases of respiratory bacterial infections associated with coronavirus disease 2019 (COVID-19) have often been reported, their impact on the clinical course remains unclear. Herein, we evaluated and analyzed complication rates infections, causative organisms, patient backgrounds, outcome in Japanese patients COVID-19.We performed a retrospective cohort study that included inpatients COVID-19 from multiple centers participating Japan Taskforce (April 2020 to May 2021) obtained...
Sorafenib is the standard treatment for advanced hepatocellular carcinoma (HCC). However, although there no proven therapeutic procedure following termination of sorafenib, hepatic arterial infusion chemotherapy (HAIC) may be a option in HCC. The aim this study was to evaluate feasibility and efficacy HAIC patients with HCC as subsequent therapy.We retrospectively evaluated 27 consecutive who were treated sorafenib between June 2009 December 2012 at our hospital. Cisplatin (20 mg/m(2) per...
Relapse and diabetes mellitus (DM) are major problems for the prognosis of autoimmune pancreatitis (AIP). We examined type 1 AIP after corticosteroid therapy (CST)-induced remission in terms relapse DM.The study enrolled 82 patients diagnosed with who achieved CST. retrospectively evaluated rate administration period CST, clinical factors associated relapse, temporal change glucose tolerance.During follow-up, 32 (39.0%) experienced relapse. There was no significant factor that could predict...
Background/Aims Anti-tumor necrosis factor drugs (anti-TNF) and thiopurines are important treatment options in patients with inflammatory bowel disease (IBD), including during pregnancy. However, there limited data on the benefit/risk profile of anti-TNF pregnancy Asia. The aim this study was to analyze outcomes female Japanese IBD treated and/or thiopurines. Methods This cross-sectional assessed 72 women IBD. Pregnancy were compared among 31 pregnancies without exposure infliximab (IFX),...
Tocilizumab, an anti-human interleukin 6 receptor (IL-6R) monoclonal antibody, is widely used to treat rheumatoid arthritis (RA) and expected exhibit clinical efficacy when other autoimmune diseases. However, a risk of opportunistic infection occasionally recognized. A 54-year-old woman had received oral corticosteroid methotrexate RA. Despite receiving these treatments, she additional treatment with tocilizumab due poor control the disease activity. She presented at our hospital high fever...
Background/Aims: Delayed bleeding is among the adverse events associated with therapeutic gastrointestinal endoscopy. The aim of this study was to evaluate risk factors for delayed after endoscopic resection in patients receiving oral anticoagulants as well compare rates occurrence between used. Methods: We retrospectively analyzed a total 772 anticoagulants. Of these, 389 and 383 were direct (DOACs) warfarin, respectively. Therapeutic procedures performed included submucosal dissection...
Granulocyte and monocyte adsorptive apheresis (GMA) has shown efficacy in patients with active Crohn's disease (CD). However, routine weekly therapy, it may take several weeks to achieve remission. This study was performed assess clinical safety of intensive GMA CD. In an open-label, prospective, randomized multicentre setting, 104 CD activity index (CDAI) 200 450 received GMA, at two sessions per week (n = 55) or one session 49). Clinical remission defined as a CDAI score <150. Patients...
This study evaluated the effectiveness of NUDT15 codon 139 genotyping in optimizing thiopurine treatment for inflammatory bowel disease (IBD) Japan, using real-world data, and aimed to establish genotype-based strategies.
Abstract Background The prognosis of patients with hepatocellular carcinoma (HCC) remains poor, largely as a result intrahepatic metastasis. Using mouse model metastasis, we investigated whether chemokine ligand 2/monocyte chemoattractant protein‐1 (CCL2/MCP‐1) could potentiate the antitumor effects herpes simplex virus thymidine kinase/ganciclovir (HSV‐tk/GCV) system. Methods Mouse hepatoma cells infected recombinant adenovirus vectors expressing HSV‐tk, CCL2/MCP‐1 and LacZ at...
Abstract Background The spread of coronavirus disease 2019 (COVID-19) had a major impact on the health people worldwide. clinical background and course inflammatory bowel (IBD) among Japanese patients with COVID-19 remains unclear. Methods This study is an observational cohort IBD diagnosed COVID-19. Data age, sex, (classification, treatment, activity), symptoms severity, treatment were analyzed. Results From 72 participating facilities in Japan, 187 registered from June 2020 to October...
Splenic artery aneurysm (SAA) is usually asymptomatic, but can be fatal if it ruptures. Portal hypertensive patients with varix or splenomegaly are sometimes complicated by SAA. However, there have been no large-scale clinical studies regarding whether liver cirrhosis itself associated splenic regardless of splenomegaly.In the present study, we retrospectively analyzed 303 cirrhotic examined arteriography. The diagnosis and characteristics SAAs were determined, relation diameter was...
Abstract Background Combining a thiopurine with the human anti-tumour necrosis factor-α monoclonal antibody adalimumab for Crohn’s disease [CD] treatment is controversial regard to efficacy and safety. By conducting subanalysis of multicentre, randomised, prospective, open-label trial [the DIAMOND study, UMIN registration number 000005146], we studied risk discontinuation in combination adalimumab. Methods In preceding analysed the: [i] timing reasons dropout monotherapy group group; [ii]...
In patients with chronic genotype 1b hepatitis C and a high viral load, the load was reduced by double filtration plasmapheresis (DFPP), followed combined interferon ribavirin therapy. The safety virological effects of this treatment method were preliminarily investigated. nine C, DFPP performed three times on days 1, 2, 4, administration initiated immediately after day 1. HCV RNA undetectable in all plasma passed through fractionator (second filter) circuit. After 2 weeks, tended to...