A5114734393- Inflammatory Bowel Disease
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Diverticular Disease and Complications
- Cancer-related molecular mechanisms research
- Gastric Cancer Management and Outcomes
- MicroRNA in disease regulation
- Health, Medicine and Society
- Diagnosis and treatment of tuberculosis
- Metastasis and carcinoma case studies
- Microscopic Colitis
- Tuberculosis Research and Epidemiology
- Colorectal Cancer Screening and Detection
- Celiac Disease Research and Management
- Esophageal Cancer Research and Treatment
- Ultrasound in Clinical Applications
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Biotechnology and Related Fields
- Erythropoietin and Anemia Treatment
- Gastrointestinal Bleeding Diagnosis and Treatment
- Pregnancy and Medication Impact
- Gut microbiota and health
- Blood properties and coagulation
- Fungal and yeast genetics research
Tohoku University Hospital
2023-2025
Tohoku University
2017-2024
Sapporo Kosei General Hospital
2021
Iwate Prefectural Central Hospital
2014
Kyorin University
1997
Chugai Pharma (United States)
1992
Higashi Nagoya National Hospital
1990
Okayama University
1989
Essa Pharma (United States)
1969
Osaka City University
1958-1961
Radial incision and cutting (RIC) is an alternative dilation method for stenosis of the lower gastrointestinal tract. However, its safety efficacy small intestine requiring balloon-assisted enteroscopy (BAE) remain limited. Therefore, this pilot study aimed to evaluate RIC using BAE. We included 10 patients with Crohn's disease performed 12 sessions lesions. The rate adverse events 1 month after was primary outcome, whereas short- long-term prognoses improvements in subjective symptoms that...
Background: Submucosal fibrosis observed during colorectal endoscopic submucosal dissection (ESD) is an important factor related to incomplete resection. Biopsy generally accepted as having the potential elicit fibrosis, but few reports have presented definitive proof. This study investigated relation between and ESD outcomes assessed factors including pretreatment biopsy. Methods: After reviewing 369 records of performed January 2011 December 2016, we outcomes. Multiple logistic regression...
MicroRNAs (miRNAs) can serve as tumor biomarkers; however, their role in evaluating colorectal adenoma (CRA) is unclear. Recently, the organoid culture system enabled long-term expansion of human colon epithelium. This study aimed to examine potential exosomal miRNAs extracted from CRA organoids biomarkers clinical liquid biopsy test.We established cultures normal and using resected specimens. Exosomes were isolated conditioned medium organoids. MiRNAs exosomes, expression profiles compared...
Abstract Background and Aims Genome-wide association studies [GWASs] of European populations have identified numerous susceptibility loci for Crohn’s disease [CD]. Susceptibility genes differ by ethnicity, however, so GWASs specific Asian are required. This study aimed to clarify the Japanese-specific genetic background CD a GWAS using Japonica array [JPA] subsequent imputation with 1KJPN reference panel. Methods Two independent Japanese case/control sets (Tohoku region [379 patients, 1621...
Aggregate formation of recombinant human erythropoietin (r-EPO) on heat-treatment was followed by gel permeation chromatography combined with a low-angle laser light scattering technique under various conditions respect to pH and salt concentration in order provide basic knowledge about the change strictly required be monitored for medicinal proteins. When heated at 60 degrees C neutral pH, an aggregate limited size consisting 20 r-EPO molecules formed. On heating 50 acidic aggregation...
Objectives. Self-expandable metallic stent (SEMS) is widely used to treat malignant colonic obstruction. However, most reports about SEMS insertion have concentrated on the left colon. This study aimed (1) investigate effectiveness of compared with conventional decompression tube for right-sided obstruction and (2) compare safety technical success between left- obstructions. Methods. The data from thirty-seven patients who underwent or placement in our hospital were analyzed retrospectively....
Vedolizumab (VDZ) is a gut-selective agent with favorable safety profile. We aimed to assess the feasibility of elective switch from other advanced therapies VDZ and subsequent live-attenuated vaccination while continuing in patients inflammatory bowel diseases (IBD).
Abstract Background and Aim Inflammatory bowel disease (IBD) frequently affects younger patients poses various challenges concerning pregnancy childbirth. Maintaining good control throughout is crucial, but expectant pregnant may worry about the fetal impact of medications, leading to treatment discontinuation due uncertainty this issue. This study investigated real‐world drug‐prescribing practices for with IBD in Japan their potential connection major congenital malformations (MCMs)....
This study evaluated the effectiveness of NUDT15 codon 139 genotyping in optimizing thiopurine treatment for inflammatory bowel disease (IBD) Japan, using real-world data, and aimed to establish genotype-based strategies.
It is crucial to pinpoint the metabolites that cause Crohn's disease (CD) and ulcerative colitis (UC) comprehend their pathogenesis identify possible targets for therapy. To achieve this goal, we performed first metabolome-wide Mendelian randomization (MR) study of Japanese patients with CD UC.
Abstract Background and Aim Although sleep disorders are associated with the pathogenesis of inflammatory bowel disease, causal relationship is unclear. Therefore, in this study we aimed to clarify between them. Methods We administered Pittsburgh Sleep Questionnaire participants during regular visits evaluate their condition, prospectively observed participants. Participants were divided into poor non-poor groups according first second questionnaire scores. compared disease relapse rates two...
Abstract Objectives Radial incision and cutting (RIC) is being investigated as an alternative endoscopic dilation method for lower intestinal tract stenosis, providing a high technical success rate improving subjective symptoms. However, several patients develop re‐stenosis following RIC. In this pilot study, we aimed to evaluate the safety efficacy of triamcinolone acetonide (TA) addition after Methods RIC with TA was performed in 20 gastrointestinal stenosis. We evaluated adverse events 2...
<b><i>Introduction:</i></b> Exosomes are membrane-enclosed nanovesicles, which increasingly being recognized as important cell communication components for their role in transmitting microRNAs (miRNAs). No previous study has addressed the exosomal miRNA profile colorectal adenomas (CRAs) because long-term culture of CRA is challenging. This aimed to identify signature organoid exosomes derived from human and cancer (CRC) samples....
Peripherally inserted central catheters (PICC) have been widely used as a blood access route for total parenteral nutrition (TPN) in recent years. However, there few reports that evaluated the usefulness of PICC patients with inflammatory bowel disease (IBD). In this study, we compared clinical courses IBD who received TPN during their hospitalization by conventional venous (CVC) and PICC.A 137 were enrolled. The CVC group included 56 81 patients, respectively. both groups retrospectively.As...
The optimal immunosuppressive therapy for elderly patients with ulcerative colitis (UC) remains unclear.We aimed to evaluate clinical practice and prognosis in UC through comparing between those elderly-onset (EOUC) longstanding (LEUC).In this retrospective single-center cohort study, we evaluated aged 60 August 2022 collecting medical record data from the time of diagnosis until 2022.The were divided into two groups based on age at disease onset: EOUC (age onset, years) LEUC <60 years).We...
The number of older patients with ulcerative colitis is increasing; however, limited data exist regarding the differences between elderly- and non-elderly-onset colitis. We aimed to compare clinical practice course elderly-onset those
During endoscopy, white spots (WS) are sometimes observed around benign or malignant colorectal tumors; however, few reports have investigated WS, and their significance remains unknown. Therefore, we the of WS from clinical pathological viewpoints evaluated its usefulness in endoscopic diagnosis.
Introduction: Although endoscopic balloon dilation (EBD) is a common therapeutic approach for managing strictures associated with Crohn’s disease (CD), the clinical application and complication rates of EBD remain unclear. Methods: We collected admission data patients who underwent using nationwide database. compared outcomes between ileal colonic strictures, CD ulcerative colitis, anastomotic arising from cancer‐related surgery. Subsequently, propensity score matching was employed to...
The efficacy of antibiotics for diverticulitis without abscess or peritonitis (uncomplicated diverticulitis) is controversial. We aimed to investigate the effectiveness uncomplicated diverticulitis.