Kazuyuki Narimatsu
A5015086368- Gastrointestinal Bleeding Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal disorders and treatments
- Inflammatory Bowel Disease
- Microscopic Colitis
- Gastrointestinal motility and disorders
- Esophageal and GI Pathology
- Cancer, Stress, Anesthesia, and Immune Response
- Diverticular Disease and Complications
- Diet and metabolism studies
- Pancreatitis Pathology and Treatment
- Gastrointestinal Tumor Research and Treatment
- Immune Response and Inflammation
- Eosinophilic Esophagitis
- Liver Disease Diagnosis and Treatment
- Gastroesophageal reflux and treatments
- Gut microbiota and health
- Gastric Cancer Management and Outcomes
- Liver Diseases and Immunity
- Inflammatory mediators and NSAID effects
- Cancer Immunotherapy and Biomarkers
- Ion Transport and Channel Regulation
- Diagnosis and treatment of tuberculosis
- Liver physiology and pathology
- Hydrogen's biological and therapeutic effects
National Defense Medical College
2013-2024
International Data Group (Sweden)
2024
National Defense Medical College Hospital
2022-2024
Ministry of Health Labour and Welfare
2024
American Society for Gastrointestinal Endoscopy
2022
University of California, Los Angeles
2014-2020
National Defence Medical Centre
2013-2020
Self-Defense Forces Central Hospital
2019
Faculdade de Ciências Médicas da Santa Casa de São Paulo
2008-2018
Bruin Biometrics (United States)
2015
Although nonalcoholic steatohepatitis (NASH) is associated with hypercholesterolemia, the underlying mechanisms of this association have not been clarified. We aimed to elucidate precise role cholesterol in pathophysiology NASH. C57BL/6 mice were fed a control, high-cholesterol (HC), methionine-choline-deficient (MCD), or MCD+HC diet for 12 weeks HC, high-fat (HF), HF+HC 24 weeks. Increased intake accelerated liver fibrosis both mouse models without affecting degree hepatocellular injury...
Key points Luminal lipid in the duodenum modulates gastroduodenal functions via release of gut hormones and mediators such as cholecystokinin 5‐HT. The effects luminal short‐chain fatty acids (SCFAs) foregut are unknown. Free acid receptors (FFARs) for long‐chain (LCFAs) SCFAs expressed enteroendocrine cells. SCFA receptors, termed FFA2 FFA3, duodenal enterochromaffin cells L cells, respectively. Activation LCFA receptor (FFA1) presumed FFA3 stimulates HCO 3 − secretion a glucagon‐like...
INTRODUCTION: The bleeding source of hematochezia is unknown without performing colonoscopy. We sought to identify whether colonoscopy a risk-stratifying tool etiology and predict outcomes presenting symptoms can differentiate the etiologies in patients with hematochezia. METHODS: This multicenter retrospective cohort study conducted at 49 hospitals across Japan analyzed 10,342 admitted for outpatient-onset acute RESULTS: Patients were mostly elderly population, 29.5% had hemodynamic...
Abstract Background Direct and indirect clipping treatments are used worldwide to treat colonic diverticular bleeding (CDB), but their effectiveness has not been examined in multicenter studies with more than 100 cases. Objective We sought determine the short‐ long‐term of direct versus for CDB a nationwide cohort. Methods studied 1041 patients who underwent ( n = 360) or 681) at 49 hospitals across Japan (CODE BLUE‐J Study). Results Multivariate analysis adjusted age, sex, important...
Lipopolysaccharides (LPS) are potent pro-inflammatory molecules that enter the systemic circulation from intestinal lumen by uncertain mechanisms. We investigated these mechanisms and effect of exogenous glucagon-like peptide-2 (GLP-2) on LPS transport in rodent small intestine. Transmucosal was measured Ussing-chambered rat jejunal mucosa. In anesthetized rats, appearance fluorescein isothiocyanate (FITC)-LPS into portal vein (PV) mesenteric lymph simultaneously monitored after...
Numerous reports have shown that a diet containing large amounts of trans fatty acids (TFAs) is major risk factor for metabolic disorders. Although recent studies TFAs promote intestinal inflammation, the underlying mechanisms are unknown. In this study, we examined effects dietary fat on dextran sodium sulphate (DSS)-induced colitis. C57 BL/6 mice were fed 1·3% (mainly C16:1, C18:1, C18:2, C20:1, C20:2 and C22:1), then colitis was induced with 1·5% DSS. Colonic damage assessed, mRNA levels...
The artificial sweetener acesulfame potassium (ACK) is officially approved as safe for intake and has been used in processed foods. However, ACKs have reported to induce metabolic syndrome, along with alteration of the gut microbiota mice. In recent years, studies suggested that this promotes myeloperoxidase reactivity Crohn's disease-like ileitis. We aimed investigate effect ACK on intestinal mucosa normal mice.Acesulfame was administered C57BL/6J mice (8 weeks old) via free drinking....
Currently, large, nationwide, long-term follow-up data on acute lower gastrointestinal bleeding (ALGIB) are scarce. We investigated risks of recurrence after hospital discharge for ALGIB using a large multicenter dataset.
The study aimed to identify prognostic factors for patients with acute lower gastrointestinal bleeding and develop a high-accuracy prediction tool. analysis included 8254 cases of hematochezia who were admitted urgently based on the judgment emergency physicians or gastroenterology consultants (from CODE BLUE J-study). Patients randomly assigned derivation cohort validation in 2:1 ratio using random number table. Assuming that present at time admission are involved mortality within 30 days...
Background and AimsWe aimed to determine the optimal timing of colonoscopy factors that benefit patients who undergo early for acute lower GI bleeding.MethodsWe identified 10,342 with hematochezia (CODE BLUE-J study) admitted 49 hospitals in Japan. Of these, 6270 underwent a within 120 hours were included this study. The inverse probability treatment weighting method was used adjust baseline characteristics among (≤24 hours, n = 4133), elective (24-48 1137), late (48-120 1000) colonoscopy....
Abstract Background Given the increasing health concerns for patients with inflammatory bowel disease (IBD), amidst COVID-19 pandemic, we investigated impact of pandemic on anxiety and behavioral changes in Japanese IBD. Methods We analyzed 3032 questionnaires from IBD, aged 16 years or older visiting 30 hospitals 1 clinic between March 2020 June 2021. The primary outcome was score experienced by IBD during pandemic. Results Participants reported a median age 44 years; 43.3% were women....
In Crohn's disease (CD), assessment of activity and extension is important for clinical management. Endoscopy the most reliable tool evaluating in these patients it distinguishes between lesions based on ulcer, erosion, redness. Magnetic resonance imaging (MRI) less invasive than endoscopy; however, sensitivity MRI detecting believed to be lower, whether can detect milder has not been studied. The aim this study was compare detection ability magnetic enterocolonography (MREC) with...
Lymphatic failure is a histopathological feature of inflammatory bowel disease (IBD). Recent studies show that interaction between platelets and podoplanin on lymphatic endothelial cells (LECs) suppresses lymphangiogenesis. We aimed to investigate the role in process colitis, which likely be through modulation Lymphangiogenesis colonic mucosal specimens from patients with IBD was investigated by studying mRNA expression lymphangiogenic factors histologically examining vessel (LV) densities....
ABSTRACT The anti-inflammatory mechanism of prebiotics has recently been shown to have an impact on the host immune system. DHNA from Propionibacterium freudenreichii is known promote proliferation Bifidobacterium and can ameliorate colitis, although its mode action remains unknown. In this study, we investigated whether attenuates inflammation in piroxicam-treated IL-10−/− mice, particularly focusing changes mechanism. was administered mice with expression adhesion molecules mRNA levels...
Glucagon-like peptide-2 (GLP-2) is a potent intestinal growth factor derived from enteroendocrine L cells. Although food intake known to increase GLP-2 secretion, its regulatory mechanisms are largely unknown as result of very short half-life in venules. The aims this study were compare the effects luminal nutrients on stimulation secretion vivo using lymph samples and clarify involvement sweet taste receptor process vitro. Lymph collected thoracic duct after bolus administration dietary...
Background and Purpose The bioactive monoamine 5‐ HT , implicated in the pathogenesis of functional gastrointestinal disorders, is abundantly synthesized stored rat proximal colonic mucosa released to gut lumen subepithelial space. Despite much data regarding its expression function, effects luminal on anion secretion have not been fully investigated. Experimental Approach We measured short‐circuit current ( I sc ) as an indicator ion transport mucosa‐submucosa or mucosa‐only preparations...
Uric acid is excreted from blood into the intestinal lumen, yet roles of uric in diseases remain to be elucidated. The study aimed determine whether could reduce end points associated with nonsteroidal anti-inflammatory drug (NSAID)-induced enteropathy.A mouse model NSAID-induced enteropathy was generated by administering indomethacin intraperitoneally 8-week-old male C57BL/6 mice, and then vehicle or administered orally. A group mice treated also concurrently inosinic acid, a precursor,...
Serotonin (5-HT), predominantly synthesized and released by enterochromaffin cells, is implicated in gastrointestinal symptoms such as emesis, abdominal pain, diarrhea. Because luminal short-chain fatty acids (SCFAs) release 5-HT from which express the SCFA receptor free acid 2 (FFA2) rat duodenum, we examined effects of selective FFA2 agonist phenylacetamide-1 (PA1) on duodenal with consequent bicarbonate secretion [duodenal (DBS)] indomethacin (IND)-induced enteropathy. Intestinal injury...