Naohiko Gunji
A5015109400- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Diverticular Disease and Complications
- Microscopic Colitis
- Inflammatory Bowel Disease
- Esophageal and GI Pathology
- Immunotherapy and Immune Responses
- Hospital Admissions and Outcomes
- Colorectal Cancer Screening and Detection
- Pancreatitis Pathology and Treatment
- Parasite Biology and Host Interactions
- Intraperitoneal and Appendiceal Malignancies
- Clinical Nutrition and Gastroenterology
- Immune Cell Function and Interaction
- Vascular anomalies and interventions
- Eosinophilic Esophagitis
- Leech Biology and Applications
- Barrier Structure and Function Studies
- Eosinophilic Disorders and Syndromes
- Polyomavirus and related diseases
- Vasculitis and related conditions
- Renal Diseases and Glomerulopathies
Fukushima Medical University
2014-2024
American Society for Gastrointestinal Endoscopy
2022
Crohn's and Colitis UK
2022
Weatherford College
2022
Saint Louis University Hospital
2016
INTRODUCTION: The bleeding source of hematochezia is unknown without performing colonoscopy. We sought to identify whether colonoscopy a risk-stratifying tool etiology and predict outcomes presenting symptoms can differentiate the etiologies in patients with hematochezia. METHODS: This multicenter retrospective cohort study conducted at 49 hospitals across Japan analyzed 10,342 admitted for outpatient-onset acute RESULTS: Patients were mostly elderly population, 29.5% had hemodynamic...
Abstract Background Direct and indirect clipping treatments are used worldwide to treat colonic diverticular bleeding (CDB), but their effectiveness has not been examined in multicenter studies with more than 100 cases. Objective We sought determine the short‐ long‐term of direct versus for CDB a nationwide cohort. Methods studied 1041 patients who underwent ( n = 360) or 681) at 49 hospitals across Japan (CODE BLUE‐J Study). Results Multivariate analysis adjusted age, sex, important...
Inflammatory bowel disease (IBD) is caused by the activation of an abnormal immune response in intestinal mucosa; spleen involved main response. Ulcerative colitis (UC) and Crohn (CD) have different inflammatory mechanisms; this study aimed to quantitatively measure compare volumes between patients with UC CD examine relationship volume activity both.We retrospectively analyzed 44 IBD aged 30-60 years (UC group, n = 24; 20). The control group comprised 19 pancreatic cysts that did not affect...
Currently, large, nationwide, long-term follow-up data on acute lower gastrointestinal bleeding (ALGIB) are scarce. We investigated risks of recurrence after hospital discharge for ALGIB using a large multicenter dataset.
Background and AimsWe aimed to determine the optimal timing of colonoscopy factors that benefit patients who undergo early for acute lower GI bleeding.MethodsWe identified 10,342 with hematochezia (CODE BLUE-J study) admitted 49 hospitals in Japan. Of these, 6270 underwent a within 120 hours were included this study. The inverse probability treatment weighting method was used adjust baseline characteristics among (≤24 hours, n = 4133), elective (24-48 1137), late (48-120 1000) colonoscopy....
Ligation therapy, including endoscopic detachable snare ligation (EDSL) and band (EBL), has emerged as an treatment for colonic diverticular bleeding (CDB); its comparative effectiveness risk of recurrent remain unclear, however. Our goal was to compare the outcomes EDSL EBL in treating CDB identify factors after therapy.We reviewed data 518 patients with who underwent (n = 77) or 441) a multicenter cohort study named Colonic Diverticular Bleeding Leaders Update Evidence From Multicenter...
Depression is implicated as a risk factor for the recurrence of inflammatory bowel disease (IBD). Near-infrared spectroscopy (NIRS) and brain-derived neurotrophic (BDNF) are useful tools evaluation brain activity depressive state, respectively. The aim this study was to clarify association between or symptoms IBD using NIRS BDNF. This included 36 ulcerative colitis (UC) patients, 32 Crohn's (CD) 17 healthy controls (HC). Center Epidemiologic Studies Scale (CES-D) scores were determined,...
Intestinal Behçet disease (BD) with myelodysplastic syndrome (MDS) is a rare condition that resistant to various immunosuppressive therapies. Several cases in which hematopoietic stem cell transplantation (HSCT) was effective for intestinal BD MDS accompanying trisomy 8 have been reported.We report an 18-year-old female 7-year history of BD. Colonoscopy demonstrated huge ulcer the cecum. Chromosomal examination revealed karyotype 87% cells. Bone marrow dysplastic cells multilineages.A...
Abstract Background The value of endoscopy for acute lower GI bleeding (ALGIB) remains unclear, given few large cohort studies. We aim to provide detailed clinical data ALGIB management and identify patients at risk adverse outcomes based on endoscopic diagnosis. Methods conducted a multicenter, retrospective study, named CODE BLUE J-Study, in 49 hospitals throughout Japan studied 10,342 cases admitted outpatient-onset hematochezia. Results Cases were mostly elderly, with 29.5% hemodynamic...
Abstract Background and Aim While short long attachment caps are available for colonoscopy, it is unclear which type more appropriate stigmata of recent hemorrhage (SRH) identification in acute hematochezia. This study aimed to compare the performance versus hematochezia diagnoses outcomes. Methods We selected 6460 patients who underwent colonoscopy with from 10 342 cases CODE BLUE‐J study. performed propensity score matching (PSM) balance baseline characteristics between cap users. Then,...
To investigate whether Imiquimod (IMQ) as TLR7 ligand protects mice from colonic inflammation and the mechanisms underlying in such immunoregulatory conditions. METHODS: Murine colitis was induced to Balb/c by administration of trinitrobenzene sulfonic acid (TNBS) with or without daily intraperitoneal IMQ. Colitis evaluated body weight decreases histological score. Also mRNA expression measured RT-PCR. confirm induction Regulatory T cells (Tregs) type-1 IFN pDCs, we generated mouse bone...
A 66-year-old man was referred to our hospital with an increasing subepithelial lesion in the gastric antrum. Using esophagogastroduodenoscopy, a tumor steep, 20-mm-high rise protruding lumen observed. The mucosal surface of reddish, ulcers forming at base. Moreover, mobile and soft. biopsy specimen taken from ulcer, but tissue not collected submucosa. Endoscopic ultrasonography (EUS) showed high echoic mass However, because ulceration red, mesenchymal internal bleeding inferred be lipoma....
Anisakiasis involves the stomach in most cases and occurs rarely small intestine. intestine is associated with abdominal pain obstruction intestinal bleeding. Unlike stomach, anisakiasis difficult to diagnose anatomically. The patient this case study developed hypovolemic shock due excessive bleeding underwent emergency surgery. With recent increase consumption of raw fish around world, report provides an important finding unknown cause.
A 66-year-old man was diagnosed from colonoscopy as having a 40-mm elevated tumor in the cecum. With preoperative diagnosis of intramucosal carcinoma, endoscopic submucosal dissection (ESD) performed. The resected en bloc, yielding specimen with 66-mm diameter. No perforation detected during operation.
A 39-year-old man presented with diarrhea and abdominal pain. At 26 years of age, he was found to have eosinophilia abnormal liver function parameters, for which prednisolone therapy started. He subsequently underwent a biopsy endoscopic retrograde cholangiopancreatography, received diagnosis primary sclerosing cholangitis (PSC). On presentation our hospital, further diagnosed eosinophilic colitis based on aggravation severe infiltration in the colonic mucosa. We herein report rare case...
A 69-year-old man was admitted to hospital with abdominal pain. In the four years prior his presentation, he had undergone repeated transarterial chemoembolizations and injections for hepatocellular carcinoma. He underwent 8th transcatheter arterial therapy one month admission. Abdominal X-rays contrast-enhanced computed tomography showed large amounts of small intestinal gas venous thrombosis from portal vein superior mesenteric vein, respectively. The reduced after anticoagulation...
This report describes a granular cell tumor (GCT) with insufficient endoscopic manipulation in the hepatic flexure (HF) of colon, which was treated by submucosal dissection (ESD) using splinting tube and spring S-O clip traction method. A 44-year-old man presented 10 mm subepithelial HF near ascending colon on colonoscopy. The lesion had smooth surface without erosion. histology biopsied specimen from suspected as GCT. Most GCTs are considered low-grade malignant, but ESD chosen to treat due...
Mesalazine-induced pericarditis is rare, and most cases occur at the time of treatment initiation. A 30-year-old man with ulcerative colitis who had experienced remission for 2 years mesalazine 2,000 mg/day subsequently relapse. Therefore, dose was increased to 4,000 mg. Thereafter, hematochezia improved, but anterior chest pain developed. Chest radiography revealed marked cardiac dilation (cardiothoracic ratio, 63%) echocardiography pericardial effusion. Adverse events associated should be...
Introduction: Length of stay (LOS) in hospital affects cost, patient quality life, and management; however, existing gastrointestinal bleeding models applicable at admission have not focused on LOS. We aimed to construct a predictive model for LOS acute lower (ALGIB). Methods: retrospectively analyzed the records 8,547 patients emergently hospitalized ALGIB 49 hospitals (the CODE BLUE-J Study). A prolonged was developed using baseline characteristics 7,107 externally validated 1,440...