A5036475624- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Pancreatitis Pathology and Treatment
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- Liver Disease and Transplantation
- Systemic Lupus Erythematosus Research
- Gastrointestinal Tumor Research and Treatment
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Metastasis and carcinoma case studies
- Esophageal and GI Pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal Cancer Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Hepatitis B Virus Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis C virus research
- IgG4-Related and Inflammatory Diseases
- Gastroesophageal reflux and treatments
- Diabetes and associated disorders
- Systemic Sclerosis and Related Diseases
- Cancer Genomics and Diagnostics
Fukushima Medical University
2016-2025
Aomori Prefectural Central Hospital
2023
Iwate Medical University
2023
Tohoku University Hospital
2023
Yamagata University
2023
Hirosaki University
2023
Sendai Medical Center
2023
National Hospital Organization
2023
Akita University
2023
Weatherford College
2020-2022
In Japan, bezafibrate (BF) is a second-line agent for primary biliary cholangitis (PBC) that refractory to ursodeoxycholic acid (UDCA) treatment. From retrospective cohort (n = 873) from the Japan PBC Study Group, we enrolled 118 patients who had received UDCA monotherapy at least 1 year followed by combination therapy with UDCA+BF year. GLOBE and UK-PBC scores after (i.e., immediately before therapy) were compared those of therapy. The real outcomes estimated Kaplan-Meier analysis predicted...
The gut microbiota has recently been recognized to play a role in the pathogenesis of autoimmune liver disease (AILD), mainly primary biliary cholangitis (PBC) and hepatitis (AIH). This study aimed analyze compare composition oral 56 patients with AILD 15 healthy controls (HCs) evaluate its association salivary immunological biomarkers microbiota. subjects included 39 PBC 17 AIH diagnosed at our hospital. control population comprised matched HCs. Salivary fecal samples were collected for...
Aim Autoimmune liver diseases (AILD) including autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and sclerosing (PSC) impose a significant burden on public health, it is important to estimate their prevalence. We carried out nationwide, hospital‐based, epidemiological survey of AIH, PBC, PSC, compared the results with those from previous surveys. Method randomly selected health‐care facilities used in list all Japan. The selection rate was determined according stratification...
Background: Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is a severe and deadly adverse event following ERCP. The ideal method for predicting PEP risk before ERCP has yet to be identified. We aimed establish simple score model (SuPER model: Support Reduction) that can applied Methods: This multicenter study enrolled 2074 patients who underwent Among them, 1037 each were randomly assigned the development validation cohorts. In cohort, was established via...
Background: This study aimed to perform a comprehensive gene expression analysis in patients with early-stage gastric cancer (EGC) identify profiles specific (GC) lesions. Methods: Biopsy specimens were collected from one EGC lesion and three background mucosal areas of scheduled for endoscopic submucosal dissection (ESD). Lesion-specific these four biopsies analyzed using DNA microarrays. Patients concurrent EGCs at the time an ESD or history GC classified into multiple group (n = 26),...
Chronic hepatitis B virus (HBV) infection is a leading cause of hepatocellular carcinoma (HCC) worldwide. Nucleos(t)ide analogues (NAs) are widely used in chronically HBV-infected patients, but the risk HCC still remains NA-treated patients. In this study, we aimed to validate scores for patients treated with nucleos(t)ide (NAs). Among total 360 who were NAs, 253 without history PAGE-B, mPAGE-B, PAGED-B, APA-B, and aMAP scores, as well recently developed score, FAL-1 which consists FIB-4...
Aim: Treatment with ursodeoxycholic acid (UDCA) improves the survival of stage I and II primary biliary cirrhosis (PBC) patients. However, new therapeutic options are needed for patients who refractory to UDCA those whose disease is at an advanced stage. Bezafibrate could be useful in PBC treatment, since it increases phospholipid output into bile reduces cytotoxicity hydrophobic acids, which increased cholestasis. Methods: We conducted two prospective, multicenter randomized open studies...
The contractile response of cultured Ito cells to endothelin-1 and substance P was examined. were obtained from rat liver by perfusion with collagenase, followed separation through centrifugal elutriation, for 24 hr. area the measured after treatment or at various concentrations in culture medium. decreased dose dependently P. before addition interleukin-1 defined as 100%. medium expressed percentage against 200 nmol/L follows: 81% +/- 13% 30 min, 77% 15% 60 87% 120 min 99% 18% 180 min....
We aimed to define the clinical features of liver dysfunction in patients with systemic lupus erythematosus (SLE).The frequency and causes were examined 206 SLE.Liver was evident 123 (59.7%) patients. Liver SLE can be drug-induced (30.9%) or caused by itself (28.5%), fatty (17.9%), autoimmune hepatitis (AIH) (4.9%), primary biliary cirrhosis (2.4%), cholangitis (1.6%), alcohol (1.6%) viral (0.8%), it tends mild except when AIH. Values for aminotransferase significantly increased AIH cause,...
Aims Although liver biopsy is crucial to diagnose and guide treatment decisions, a detailed histological analysis of autoimmune hepatitis (AIH) with clinically acute presentations has not yet been performed. This study aimed characterise the features explore potential hallmarks presentation AIH. Methods We systematically evaluated specimens 87 adult patients AIH retrospectively enrolled from Japanese multicentre facilities. Each feature was predefined by consensus based on diagnostic...
There is limited information regarding the benefits of Lenvatinib-transcatheter arterial chemoembolization (LEN-TACE) sequential therapy for unresectable hepatocellular carcinoma (u-HCC). We compared efficacy and safety LEN-TACE to LEN monotherapy investigated factors contributing deep response.We enrolled a multicenter cohort 247 patients with u-HCC treated between 2018 2020. Propensity score matching identified 63 pairs well-balanced characteristics. retrospectively clinical outcomes,...
Reactivation of chronic hepatitis B virus (HBV) infection in patients undergoing chemotherapy is well-documented, but reactivation during imatinib mesylate treatment has not been reported. This study reports a 54-year-old man, without prior liver dysfunction with HBV infection, whom fatal occurred myeloid leukemia (CML) mesylate. He developed fulminant followed by marked elevation DNA polymerase, probably from the lymphocytopenic and immunosuppressive status induced Imatinib widely used to...
Liver dysfunction is not rare in patients with collagen disease. We sought to elucidate the clinical features of liver presence analyzed frequency and causes 607 (rheumatoid arthritis [RA], n = 220; systemic lupus erythematosus [SLE], 164; sclerosis [SSc], 47; Sjögren's syndrome [SjS], 44; Behçet's disease, 43; polymyositis/dermatomyositis [PM/DM], 27; vasculitis syndrome, 25; mixed connective tissue disease [MCTD], 21; adult-onset Still's [AOSD], 16). was observed 238 (39.2%) showing...
To examine the relationship between sleep duration and non-alcoholic fatty liver disease (NAFLD).We evaluated 3,968 subjects who underwent health check-ups from June 2012 to May 2013 at Watari Hospital Health Center in Fukushima Prefecture Japan. Fatty was detected by ultrasonography. Sleep lifestyle factors were estimated using a questionnaire. categorized into following groups: ≤ 6, 6 7, >7 8, >8 h. The four groups compared χ(2) test Kruskal-Wallis test.In total, 2,172 enrolled. overall...
Introduction: A prior study with 22‐gauge needles recommended more than seven needle passes for endoscopic ultrasound‐guided fine‐needle aspiration biopsy (EUS‐FNA) of solid pancreatic lesions (SPL) without onsite cytopathology optimal acquisition cytopathological diagnosis. The feasibility this recommendation should be re‐evaluated considering the later development and popularity 25‐gauge EUS‐FNA needles. We aimed to determine number specimen SPL. Methods: preliminary prospective 22...
Aim Sarcopenia has a negative impact on the prognosis of patients with hepatocellular carcinoma (HCC). We investigated significance skeletal muscle volume and its changes in HCC receiving transarterial chemoembolization (TACE). Methods retrospectively analyzed 179 TACE from 2006 to 2017. Skeletal mass index was calculated as left–right sum major × minor axis psoas at third lumbar vertebra, divided by height squared (psoas [PMI]). Patients were classified into two groups (low normal PMI)...
A previous genome-wide association study (GWAS) performed in 963 Japanese individuals (487 primary biliary cholangitis [PBC] cases and 476 healthy controls) identified TNFSF15 (rs4979462) POU2AF1 (rs4938534) as strong susceptibility loci for PBC. In this study, we GWAS additional 1,923 (894 PBC 1,029 controls), combined the results with data. This GWAS, together a subsequent replication an independent set of 7,024 (512 6,512 PRKCB (rs7404928) novel locus (odds ratio [OR] = 1.26, P 4.13 ×...