A5038918825- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Pediatric Hepatobiliary Diseases and Treatments
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- Systemic Lupus Erythematosus Research
- Liver physiology and pathology
- Hepatitis Viruses Studies and Epidemiology
- Pancreatitis Pathology and Treatment
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Drug-Induced Hepatotoxicity and Protection
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Drug Transport and Resistance Mechanisms
- Macrophage Migration Inhibitory Factor
- Gastric Cancer Management and Outcomes
- Monoclonal and Polyclonal Antibodies Research
- Nitric Oxide and Endothelin Effects
- Gallbladder and Bile Duct Disorders
- Genomics, phytochemicals, and oxidative stress
- Computational Drug Discovery Methods
Jikei University School of Medicine
2012-2024
Sanno Medical Center
2016-2024
International University of Health and Welfare
2016-2023
Hospital de São João
2023
University of Alberta Hospital
2022
Alberta Hospital Edmonton
2022
Fujieda Municipal General Hospital
2017
Creative Research Enterprises (United States)
2017
The Jikei University Hospital
2014
Hospital Clínic de Barcelona
2011
Diagnosis of autoimmune hepatitis (AIH) may be challenging. However, early diagnosis is important because immunosuppression life-saving. Diagnostic criteria the International Autoimmune Hepatitis Group (IAIHG) were complex and purely meant for scientific purposes. This study IAIHG aims to define simplified diagnostic routine clinical practice. Candidate included sex, age, autoantibodies, immunoglobulins, absence viral hepatitis, histology. The training set 250 AIH patients 193 controls from...
Abstract Emerging evidence has suggested environmental factors as causative agents in the pathogenesis of primary biliary cirrhosis (PBC). We have hypothesized that PBC lipoyl domain immunodominant E2 component pyruvate dehydrogenase (PDC-E2) is replaced by a chemical xenobiotic mimic, which sufficient to break self-tolerance. To address this hypothesis, based upon our quantitative structure-activity relationship data, total 107 potential mimics were coupled lysine residue 15 amino acid...
Abstract Liver cancers, including hepatocellular carcinomas (HCCs), cholangiocarcinomas (CCs), and fibrolamellar HCCs (FL-HCCs) are among the most common cancers worldwide associated with a poor prognosis. Investigations of genes important in liver have focused on Sal-like protein 4 (SALL4), member family zinc finger transcription factors. It is regulator embryogenesis, organogenesis, pluripotency, can elicit reprogramming somatic cells, marker stem cells. We found it expressed normal murine...
Aim: Treatment with ursodeoxycholic acid (UDCA) improves the survival of stage I and II primary biliary cirrhosis (PBC) patients. However, new therapeutic options are needed for patients who refractory to UDCA those whose disease is at an advanced stage. Bezafibrate could be useful in PBC treatment, since it increases phospholipid output into bile reduces cytotoxicity hydrophobic acids, which increased cholestasis. Methods: We conducted two prospective, multicenter randomized open studies...
Tim-3, a member of the T cell Ig mucin (TIM) family regulates effector Th1 responses. We examined Tim-3 and its ligand expression as well effects anti-Tim-3 mAb treatment in murine model acute graft-vs-host disease (aGVHD). In mice with aGVHD, was markedly up-regulated on splenic hepatic CD4+ CD8+ cells, dendritic cells (DCs), macrophages, this especially dramatic cells. Both donor- host-derived induced similar levels Tim-3. also DCs, but not lymphocytes. The administration mAbs accelerated...
Aims Although liver biopsy is crucial to diagnose and guide treatment decisions, a detailed histological analysis of autoimmune hepatitis (AIH) with clinically acute presentations has not yet been performed. This study aimed characterise the features explore potential hallmarks presentation AIH. Methods We systematically evaluated specimens 87 adult patients AIH retrospectively enrolled from Japanese multicentre facilities. Each feature was predefined by consensus based on diagnostic...
Hepatocellular carcinoma (HCC) occurs more frequently in patients with hepatitis C virus (HCV)-related chronic liver disease than those B virus-related disease. It is important to assess the factors affecting development of HCC.A long term follow-up study involving HCV was performed retrospectively. A total 153 diagnosed between June 1981 and November 1990 or without cirrhosis by biopsy were enrolled a (average, 99.4 months) cumulative incidence rate HCC appearance examined.The 5-year 9%,...
A previous genome-wide association study (GWAS) performed in 963 Japanese individuals (487 primary biliary cholangitis [PBC] cases and 476 healthy controls) identified TNFSF15 (rs4979462) POU2AF1 (rs4938534) as strong susceptibility loci for PBC. In this study, we GWAS additional 1,923 (894 PBC 1,029 controls), combined the results with data. This GWAS, together a subsequent replication an independent set of 7,024 (512 6,512 PRKCB (rs7404928) novel locus (odds ratio [OR] = 1.26, P 4.13 ×...
Autoimmune hepatitis (AIH), initially called chronic aggressive hepatitis, is conceptually classified as a primary disease; periportal fibrous expansion and infiltration of mononuclear cells, including plasma have also been considered to be histologically important diagnostic signs AIH. However, several manuscripts which reported the acute presentation AIH published recently cases in these contained two different clinical entities. One exacerbation (acute form) other genuine without...
The aim of the present study is to evaluate factors influencing biochemical response treatment and value for predicting long-term outcomes in Japanese patients with primary biliary cirrhosis (PBC).Biochemical ursodeoxycholic acid (UDCA) or UDCA plus bezafibrate was defined as good (≤upper limit normal [ULN]), fair (≤1.5 × ULN) poor (>1.5 at 2 years after initiation treatment. Associations between various (including age, sex, autoantibody status histological variables baseline), were...
The incidence of non-alcoholic fatty liver disease (NAFLD) is increasing all over the world. NAFLD develops in patients with disease, including autoimmune hepatitis (AIH). and AIH have some similar laboratory histological findings. aim this study was to elucidate characteristics NAFLD.We re-evaluated nationwide survey performed Japan 2015 diagnosed between 2009 2013.A total 1151 subjects (144 men 1007 women) were enrolled present study. overall prevalence 17.0%. Compared without NAFLD, had...