A5003895611- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Contact Dermatitis and Allergies
- Drug-Induced Adverse Reactions
- Liver Diseases and Immunity
- Hepatitis C virus research
- Hepatitis Viruses Studies and Epidemiology
- Autoimmune Bullous Skin Diseases
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Milk Quality and Mastitis in Dairy Cows
- Occupational exposure and asthma
- Urticaria and Related Conditions
- Liver Disease and Transplantation
- Nail Diseases and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Dermatological diseases and infestations
- Autoimmune and Inflammatory Disorders
- Food Allergy and Anaphylaxis Research
- Animal Virus Infections Studies
- SARS-CoV-2 and COVID-19 Research
- Psoriasis: Treatment and Pathogenesis
- Protein Hydrolysis and Bioactive Peptides
- Eosinophilic Disorders and Syndromes
- Entomological Studies and Ecology
University of Perugia
2016-2025
Génétique Animale et Biologie Intégrative
2012-2022
Physiologie Environnement et Génétique pour l'Animal et les Systèmes d'Elevage
2022
AgroParisTech
2022
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2022
Université Paris-Saclay
2022
Institut Agro Rennes-Angers
2022
University of Rome Tor Vergata
2022
University of Padua
2020
Michigan United
2020
ABSTRACT Plus-strand RNA viruses characteristically replicate their genome in association with altered cellular membranes. In the present study, capacity of hepatitis C virus (HCV) proteins to elicit intracellular membrane alterations was investigated by expressing, tetracycline-regulated cell lines, a comprehensive panel HCV individually as well context entire polyprotein. As visualized electron microscopy (EM), expression combined structural core-E1-E2-p7, NS3-4A complex, and protein NS4B...
Patch testing is the standard procedure used to diagnose allergic contact dermatitis. It an in-vivo test, which reproduces reaction a allergen. This test aims reproduce elicitation phase of dermatitis and performed applying allergens under occlusion on skin standardized conditions. These guidelines for best practice in performing patch have been developed by Italian group experts taking account legislation local pharmacological governance. Guidelines are adapted from original article...
Moderate-to-severe atopic dermatitis (AD) in the adolescence is a high burden disease, and its treatment can be very challenging due to paucity of approved systemic drugs for this age their side-effects. Dupilumab was recently adolescent AD.A multicentre, prospective, real-world study on effectiveness safety dupilumab adolescents (aged from ≥12 <18 years) with moderate-to-severe AD conducted. The main clinical phenotypes were also examined.Data treated at label dosage 16 weeks collected....
Diabetic macular edema (DME) is the main cause of visual impairment in patients with diabetic retinopathy (DR) and anti-vascular endothelial growth factor (anti-VEGF) therapy standard care for DME [1]. Herein, we report a case co-sensitivity to chloramphenicol povidone-iodine secondary intravitreal injection (IVI) bevacizumab patient bilateral DME. A 49-year-old man type-II diabetes DR, complicated by both eyes, was referred us an itchy eczematous dermatitis periocular region right eye,...
Serial liver biopsies are the gold standard by which progression of fibrosis is evaluated. This longitudinal cohort study assessed different rates in using serial and serum markers YKL-40 PIIINP cytokines, transforming growth factor beta (TGF-β) tumor necrosis alpha (TNF−α). A 10-year was performed patients with hepatitis C virus (HCV) alone or HCV schistosomiasis. Patients were enrolled at time acute infection prospectively evaluated two (at entry end follow-up), true calculated per year....
Abstract: Background/Aims: Infection with Schistosoma mansoni is endemic in Egypt leading to hepatic schistosomiasis and eventually portal hypertension. The prevalence of antibodies against hepatitis virus C among Egyptians 14–51%. aim the present study was investigate influence on chronic respect natural course disease, immunology, virology histology. Patients Methods: One hundred twenty‐six Egyptian patients classified into three groups: group A: ( n =33); B: =30) C: =63) were enrolled...
The presence of albumin receptors on the plasma membrane isolated human hepatocytes was investigated employing albumin-coupled latex minibeads. Hepatocyte-latex reaction visualized by phase contrast and scanning electron microscopy. experiments demonstrate that exhibit binding activity for polymeric monomelic forms glutaraldehyde-treated albumin. Additionally, shown to be species-nonspecific. These findings support hypothesis polymerized may act as a bridge between hepatitis B virus hepatocytes.
Summary Background The prevalence of occupational and non‐occupational textile dermatitis seems to be increasing, probably because changed manufacturing techniques. Objective Evaluation the clinical features epidemiology contact ( TCD ) in I taly. Methods Demographic data, history aspects, atopy positive patch test reactions allergens were investigated 277 patients. Results Contact was most frequent presentation (95.3%). more common females, fourth fifth decades life, atopic lesions...
Atopic dermatitis (AD) therapeutic approach calls for a long-term treatment. Treatment options AD have recently undergone revolutionary change by the introduction of first biologic drug. Availability in daily practice last version international guidelines, taking peculiarities country into account, can contribute to good clinical Italy. To adapt European Dermatology Forum (EDF) guidelines Italian medical–legal context, EDF were assessed independently two independent renowned experts field...
The kinetics of intrahepatic hepatitis C virus (HCV)-specific CD4+ T cell responses and their role in progression fibrosis have not previously been characterized. Subjects with HCV/Schistosoma mansoni coinfection a more rapid HCV liver than do those infection alone. present prospective longitudinal study compared the histology, HCV-specific peripheral proliferative responses, cytokines (enzyme-linked immunospot) 48 subjects unresolved acute or without S. coinfection, at 6-10 months after end...
The finding that the recently described hepatitis B (HB)-associated delta antigen (δ Ag) is preserved in pronase-treated, formalin-fixed paraffin sections allowed a combined prospective and retrospective immunohistological study of its occurrence 571 liver biopsies. Among 116 frozen biopsies (69 HBAg seropositive, 47 seronegative) 455 paraffin-embedded (296 159 HBAg-negative), δ Ag was found 10 seropositive patients. With exception 1 patient with chronic persistent HB, all had chronic-active...
Coded examination of liver biopsies from a total 24 patients with acute hepatitis non-A, non-B revealed two main histological trends: (a) viral confluent necrosis (sublobular and bridging) carrying relatively good prognosis taking chronic course in only four out 14 (29%); (b) severe portal infiltration rich lymphocytes plasma cells, lymph follicles germinal centers bile duct lesions, as described by Poulsen & Christoffersen. The latter group showed very high tendency to transition (six seven...
Psoriasis can be managed successfully with long-term biologics. Real-life clinical practice may require dose tapering as a therapeutic option to reduce the risk of drug-exposure and increase cost-effectiveness. The responsiveness extended intervals between adalimumab doses possible predictive factors maintenance complete clearance were studied in retrospective 7-year single-centre analysis. Thirty patients who achieved underwent tapering, progressively extending between-dose (to 21?28 days)....