A5050578320- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Metabolomics and Mass Spectrometry Studies
- Glutathione Transferases and Polymorphisms
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Pharmacogenetics and Drug Metabolism
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Redox biology and oxidative stress
- Free Radicals and Antioxidants
- Trace Elements in Health
- ATP Synthase and ATPases Research
- Alcohol Consumption and Health Effects
- Hemoglobin structure and function
- Metabolism and Genetic Disorders
- Immune Response and Inflammation
- Cancer-related Molecular Pathways
- Hepatocellular Carcinoma Treatment and Prognosis
- Biochemical effects in animals
- Drug Transport and Resistance Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Antioxidant Activity and Oxidative Stress
- Photosynthetic Processes and Mechanisms
- Lipid metabolism and biosynthesis
- Mass Spectrometry Techniques and Applications
University of Padua
2023-2025
University of Perugia
2023-2025
Università Cattolica del Sacro Cuore
2001-2011
Toxicologie, Pharmacologie et Signalisation Cellulaire
2010-2011
Catholic University of America
1980-2010
Agostino Gemelli University Polyclinic
2009
Universitat de Barcelona
2009
Ankara University
2007
University of Antwerp
2006
University of the Sacred Heart
2002-2004
Signal transduction by reactive oxygen species (ROS; “redox signaling”) has recently come into focus in cellular biology studies. The signaling properties of ROS are largely due to the reversible oxidation redox-sensitive target proteins, and especially protein tyrosine phosphatases, whose activity is dependent on redox state a low pKa active site cysteine. A variety mitogenic signals, including those released receptor kinase (RTKs) ligands oncogenic H-Ras, involve as critical downstream...
Recent evidence shows the involvement of reactive oxygen species (ROS) in mitogenic cascade initiated by tyrosine kinase receptors several growth factor peptides. We have asked whether also vascular endothelial (VEGF) utilizes ROS as messenger intermediates downstream VEGF receptor-2 (VEGFR-2)/KDR receptor given that proliferation cells during neoangiogenesis is physiologically regulated and likely its derivative species. In porcine aortic stably expressing human KDR, activation followed a...
Calorie restriction delays brain senescence and prevents neurodegeneration, but critical regulators of these beneficial responses other than the NAD(+)-dependent histone deacetylase Sirtuin-1 (Sirt-1) are unknown. We report that effects calorie on neuronal plasticity, memory social behavior abolished in mice lacking cAMP responsive-element binding (CREB)-1 forebrain. Moreover, CREB deficiency drastically reduces expression Sirt-1 induction genes relevant to metabolism survival cortex...
Reactive oxygen species (ROS) have recently drawn significant attention as putative mitogenic mediators downstream of activated growth factor receptors and oncogenic Ras; however, the possibility that a redox-related mechanism also operates in negative control cell proliferation by inhibitory signals has not been investigated thus far. Here we show arrest induced confluence ("contact inhibition") is due, at least part, to decrease steady-state levels intracellular ROS consequent impairment...
Abstract Bilirubin is neurotoxic upon excess accumulation in the brain, but it also plays important physiological roles related to its antioxidant properties. Here we report that exposure of PC12 and primary rat cerebellar granule neurons bilirubin (0.5–10 μM) drastically decreases nerve growth factor (NGF)/brain‐derived neurotrophic signaling Akt extracellular signal‐regulated kinases (ERKs), indicating a direct interference molecule with crucial prosurvival pathways. This effect likely...
Obesity and metabolic syndrome result from excess calorie intake genetic predisposition are mechanistically linked to type II diabetes accelerated body aging; abnormal nutrient insulin signaling participate in this pathologic process, yet the underlying molecular mechanisms incompletely understood. Mice lacking p66 kDa isoform of Shc adaptor molecule live longer leaner than wild-type animals, suggesting that may have a role derangement premature senescence by overnutrition. We found...
Reactive oxygen species (ROS) act as both signaling molecules and mediators of cell damage in the nervous system are implicated pathogenesis neurodegenerative diseases. Neurotrophic factors such nerve-derived growth factor (NGF) support neuronal survival during development promote regeneration after injury through activation intracellular signals whose molecular effectors downstream targets still largely unknown. Here we present evidence that early oxidative initiated by NGF PC12 cells, an...
ABSTRACT In literature, there is a paucity of research examining the outcomes mentoring programs for mentors. The goal this study was to enhance understanding long‐term impact experiences on mentors' social well‐being by testing model in which perceived influence work choices, volunteer choices and level active participation community are associated with self‐efficacy, civic engagement (attitudes behaviours), and, turn, wellbeing. This surveyed cohorts former mentors ( N = 203; 83% female)...
Diabetic macular edema (DME) is the main cause of visual impairment in patients with diabetic retinopathy (DR) and anti-vascular endothelial growth factor (anti-VEGF) therapy standard care for DME [1]. Herein, we report a case co-sensitivity to chloramphenicol povidone-iodine secondary intravitreal injection (IVI) bevacizumab patient bilateral DME. A 49-year-old man type-II diabetes DR, complicated by both eyes, was referred us an itchy eczematous dermatitis periocular region right eye,...
Molecular events mediating the T-lymphocyte response to lectins are still incompletely understood, although much evidence suggests that both mitogenic and death-promoting effects of these agents involve biochemical cascade initiated by CD3/T-cell antigen receptor (TCR) complex. Reactive oxygen species (ROS) in particular H2O2 have been shown a role cell cytokines growth factors. Here we report proliferation mouse thymocytes lectin concanavalin A (ConA) is strongly selectively inhibited...