A5053592791- Biochemical effects in animals
- Heme Oxygenase-1 and Carbon Monoxide
- Genomics, phytochemicals, and oxidative stress
- Genetics, Aging, and Longevity in Model Organisms
- Mitochondrial Function and Pathology
- Alzheimer's disease research and treatments
- Adipose Tissue and Metabolism
- Medicinal Plants and Bioactive Compounds
- Phytochemicals and Antioxidant Activities
- Redox biology and oxidative stress
- Bee Products Chemical Analysis
- Alcohol Consumption and Health Effects
- Tryptophan and brain disorders
- Heat shock proteins research
- Sulfur Compounds in Biology
- Free Radicals and Antioxidants
- Effects of Radiation Exposure
- Sirtuins and Resveratrol in Medicine
- Neuroinflammation and Neurodegeneration Mechanisms
- Antioxidant Activity and Oxidative Stress
- Parkinson's Disease Mechanisms and Treatments
- Stress Responses and Cortisol
- Cholinesterase and Neurodegenerative Diseases
- Diet and metabolism studies
- Curcumin's Biomedical Applications
University of Catania
2016-2025
Università Campus Bio-Medico
2024
Campus Bio Medico University Hospital
2024
Université Ibn-Tofail
2023
Ospedale G.F. Ingrassia
2023
University of Messina
2021
University of Ferrara
2019
University of Massachusetts Amherst
2015
University of Sannio
2014-2015
Istituto Nazionale Biostrutture e Biosistemi
2011
The antioxidant and anti-inflammatory effects of hormetic nutrition for enhancing stress resilience overall human health have received much attention. Recently, the gut-brain axis has attracted prominent interest preventing therapeutically impacting neuropathologies gastrointestinal diseases. Polyphenols polyphenol-combined nanoparticles in synergy with probiotics shown to improve gut bioavailability blood-brain barrier (BBB) permeability, thus inhibiting oxidative stress, metabolic...
Recent studies have demonstrated that the interaction of dietary constituents with taste and olfactory receptors nociceptors expressed in oral cavity, nasal cavity gastrointestinal tract regulate homeostasis through activation neuroendocrine system. Polyphenols, which 8000 been identified to date, represent greatest diversity secondary metabolites plants, most are bitter some them astringent. Epidemiological shown polyphenol intake contributes maintaining improving cardiovascular, cognitive...
Heme oxygenase-1 (HO-1) is a redox-sensitive inducible protein that provides efficient cytoprotection against oxidative stress. Curcumin, polyphenolic natural compound possesses anti-tumor and anti-inflammatory properties, has been reported recently to induce potently HO-1 expression in vascular endothelial cells (<i>Free Rad Biol Med</i><b>28:</b>1303–1312, 2000). Here, we extend our previous findings by showing caffeic acid phenethyl ester (CAPE), another plant-derived phenolic agent,...
Abstract Alzheimer's disease (AD) is neuropathologically characterized by depositions of extracellular amyloid and intracellular neurofibrillary tangles, associated with loss neurons in the brain. Amyloid β‐peptide (Aβ) major component senile plaques considered to have a causal role development progress AD. Several lines evidence suggest that enhanced oxidative stress inflammation play important roles pathogenesis or progression The present study aimed investigate protective effects...
The stress protein heme oxygenase-1 (HO-1) is induced in endothelial cells exposed to nitric oxide (NO)-releasing agents, and this process finely modulated by thiols (Foresti, R., Clark, J. E., Green, C. J., Motterlini R. (1997) <i>J. Biol. Chem.</i> 272, 18411–18417). Here, we report that up-regulation of HO-1 aortic severe hypoxic conditions (<i>p</i>O<sub>2</sub> ≤ 2 mm Hg) preceded increased inducible NO synthase activity. This effect accompanied oxidation intracellular glutathione...
Alzheimer's disease (AD) is a neurodegenerative disorder with cognitive and memory decline, personality changes, synapse loss. Increasing evidence indicates that factors such as oxidative nitrosative stress, glutathione depletion, impaired protein metabolism can interact in vicious cycle, which central to AD pathogenesis. In the present study, we demonstrate brains of patients undergo changes classically associated strong induction so-called vitagenes, including heat shock proteins (HSPs)...