A5081238812- Biochemical effects in animals
- Medicinal Plants and Bioactive Compounds
- Genomics, phytochemicals, and oxidative stress
- Genetics, Aging, and Longevity in Model Organisms
- Vitamin C and Antioxidants Research
- Antioxidant Activity and Oxidative Stress
- Phytochemicals and Antioxidant Activities
- Stress Responses and Cortisol
- Heme Oxygenase-1 and Carbon Monoxide
- Adipose Tissue and Metabolism
- Fungal Biology and Applications
- Bee Products Chemical Analysis
- Neurological Disease Mechanisms and Treatments
- Tryptophan and brain disorders
- S100 Proteins and Annexins
- Vestibular and auditory disorders
- Effects and risks of endocrine disrupting chemicals
- Diet, Metabolism, and Disease
- Curcumin's Biomedical Applications
- Edible Oils Quality and Analysis
- Hearing, Cochlea, Tinnitus, Genetics
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Parkinson's Disease Mechanisms and Treatments
- Glaucoma and retinal disorders
- Olfactory and Sensory Function Studies
University of Catania
2014-2024
Ospedale G.F. Ingrassia
2023
Centro di Riferimento Oncologico
2021
Istituti di Ricovero e Cura a Carattere Scientifico
2021
The antioxidant and anti-inflammatory effects of hormetic nutrition for enhancing stress resilience overall human health have received much attention. Recently, the gut-brain axis has attracted prominent interest preventing therapeutically impacting neuropathologies gastrointestinal diseases. Polyphenols polyphenol-combined nanoparticles in synergy with probiotics shown to improve gut bioavailability blood-brain barrier (BBB) permeability, thus inhibiting oxidative stress, metabolic...
Numerous studies highlighted the beneficial effects of Mediterranean diet (MD) in maintaining health, especially during ageing. Even neurodegeneration, which is part natural ageing process, as well foundation ageing-related neurodegenerative disorders like Alzheimer's and Parkinson's disease (PD), was successfully targeted by MD. In this regard, olive oil its polyphenolic constituents have received increasing attention last years. Thus, study focuses on two main polyphenols, hydroxytyrosol...
In developed countries, the extension of human life is increasingly accompanied by a progressive increase in neurodegenerative diseases, most which do not yet have effective therapy but only symptomatic treatments. recent years, plant polyphenols aroused considerable interest scientific community. The mechanisms currently hypothesized for pathogenesis Parkinson's disease (PD) are neuroinflammation, oxidative stress and apoptosis. Hydroxytyrosol (HT), main component Hidrox® (HD), has been...
Parkinson’s disease (PD) is the second most prevalent late-age onset neurodegenerative disorder, affecting 1% of population after age about 60 years old and 4% those over 80 old, causing motor impairments cognitive dysfunction. Increasing evidence indicates that Mediterranean diet (MD) exerts beneficial effects in maintaining health, especially during ageing by prevention disorders. In this regard, olive oil its biophenolic constituents like hydroxytyrosol (HT) have received growing...
Background: Anacardium occidentale L. is a medicinal plant with powerful anti-oxidative and anti-inflammatory properties. Acute inflammatory events cause tissue alterations, decrease of endogenous enzymes such as superoxide dismutase, catalase glutathione, neutrophils infiltration, increase in the activities myeloperoxidase, malondialdehyde, pro-inflammatory release. Methods: Paw edema was induced by subplantar injection carrageenan into right hind paw rats, but 30 min before group animals...
There has been a recent upsurge of interest in complementary medicine, especially dietary supplements and foods functional delaying the onset age-associated neurodegenerative diseases. Mushrooms have long used traditional medicine for thousands years, being now increasingly recognized as antitumor, antioxidant, antiviral, antibacterial hepatoprotective agent also capable to stimulate host immune responses.Here we provide evidence neuroprotective action Hericium Herinaceus when administered...
Amyloid deposits, constituted of amyloid beta (Aβ) aggregates, are a characteristic feature several neurodegenerative diseases, such as Alzheimer's, mild cognitive impairment and Parkinson's disease. They also have been recently implicated in the pathogenesis retinal damage, well age-related macular degeneration glaucoma. Glaucoma is progressive optic neuropathy characterized by gradual neuronal tissue due to ganglion cell loss, associated visual field loss over time resulting irreversible...
In rodents, carnosine treatment improves diabetic nephropathy, whereas little is known about the role and function of anserine, methylated form carnosine. Antioxidant activity was measured by oxygen radical absorbance capacity stress response in human renal tubular cells (HK-2) RT-PCR Western-Immunoblotting. wildtype (WT) mice (db/db), effect short-term anserine on blood glucose, proteinuria vascular permeability measured. Anserine has a higher antioxidant compared to (p < 0.001). stressed...
Diabetes causes various macrovascular and microvascular alterations, often culminating in major clinical complications (first of all, stroke) that lack an effective therapeutic intervention. N-palmitoylethanolamide-oxazoline (PEA-OXA) possesses anti-inflammatory potent neuroprotective effects. Although recent studies have explained the properties PEA-OXA, nothing is known about its effects treating cerebral ischemia. Methods: Focal ischemia was induced by transient middle artery occlusion...
Chronic rejection is the major leading cause of morbidity and mortality after lung transplantation. Bronchiolitis obliterans syndrome (BOS), a fibroproliferative disorder small airways, main manifestation chronic allograft rejection. We investigated, using transgenic mice, mechanisms through which deficiency IL-1β/IL-18, Casp-1, or Fpr-1 genes could be protective in an experimental model BOS, induced mice by allogeneic heterotopic tracheal KO showed marked reduction histological markers BOS...
Traumatic brain injury (TBI) is a shocking disease frequently followed by behavioral disabilities, including risk of cerebral atrophy and dementia. N-formylpeptide receptor 1 (FPR1) expressed in cells neurons the central nervous system. It involved inflammatory processes during differentiation process neural stem cells. We investigate effect absence Fpr1 gene expression mice subjected to TBI from early stage acute inflammation neurogenesis systematic testing four weeks after injury. C57BL/6...
Meniere’s disease (MD) represents a clinical syndrome characterized by episodes of spontaneous vertigo, associated with fluctuating, low to medium frequencies sensorineural hearing loss (SNHL), tinnitus, and aural fullness affecting one or both ears. To date, the cause MD remains substantially unknown, despite increasing evidence suggesting that oxidative stress neuroinflammation may be central development endolymphatic hydrops consequent otholitic degeneration displacement in reuniting...
Background: The activity of the hypothalamic-pituitary-adrenal (HPA) axis is commonly dysregulated in stress-related psychiatric disorders. Annexin A1 (ANXA1), an endogenous ligand formyl peptide receptor (FPR) 2/3, a member family phospholipid- and calcium-binding proteins with well-defined role delayed early inhibitory feedback glucocorticoids (GC) pituitary gland implicated occurrence behavioural disorders such as anxiety. Objective: present study aimed to evaluate potential ANXA1 its...
Background: Every year, men use cyclophosphamide to treat various cancers and autoimmune diseases. On the one hand, this chemotherapy often has beneficial effect of regressing tumor, but on other it leads infertility due excessive oxidative stress apoptosis in testes caused by its metabolite, acrolein. Methods: The objective study was evaluate power a new compound called Hidrox®, containing 40–50% hydroxytyrosol, counteracting damage related fertility induced cyclophosphamide. conducted...
Traumatic brain injury (TBI) is a major health and socioeconomic problem affecting the world. This condition results from application of external physical force to which leads transient or permanent structural functional impairments. TBI has been shown be risk factor for neurodegeneration can lead Parkinson's disease (PD) example. In this study, we wanted explore development PD-related pathology in context an experimental model potential ability Coriolus versicolor Hericium erinaceus prevent...