A5031603094- Hemoglobinopathies and Related Disorders
- Liver Disease Diagnosis and Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Antibiotic Resistance in Bacteria
- Adipose Tissue and Metabolism
- Pleural and Pulmonary Diseases
- Diabetes Management and Education
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Myasthenia Gravis and Thymoma
- Digital Imaging for Blood Diseases
- COVID-19 Clinical Research Studies
- Endoplasmic Reticulum Stress and Disease
- Pancreatic function and diabetes
- AI in cancer detection
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Metabolism, Diabetes, and Cancer
- Neonatal Health and Biochemistry
- Bacterial Identification and Susceptibility Testing
- COVID-19 diagnosis using AI
- PI3K/AKT/mTOR signaling in cancer
- Occupational and environmental lung diseases
- Circadian rhythm and melatonin
- Cancer Risks and Factors
- Cancer, Hypoxia, and Metabolism
- Genomic variations and chromosomal abnormalities
University of Teramo
2020-2024
Presidio Ospedaliero
2024
Fondazione Cassa di Risparmio Civitavecchia
2023
Sapienza University of Rome
2019-2020
Ospedale Santa Maria
2015
University School
2014
Foro Italico University of Rome
2014
Case Western Reserve University
2014
Azienda Ospedaliera S.Maria
2013
Toxicologie, Pharmacologie et Signalisation Cellulaire
2010-2011
Calorie restriction delays brain senescence and prevents neurodegeneration, but critical regulators of these beneficial responses other than the NAD(+)-dependent histone deacetylase Sirtuin-1 (Sirt-1) are unknown. We report that effects calorie on neuronal plasticity, memory social behavior abolished in mice lacking cAMP responsive-element binding (CREB)-1 forebrain. Moreover, CREB deficiency drastically reduces expression Sirt-1 induction genes relevant to metabolism survival cortex...
Aim of this study was to compare cancer incidence in populations with and without diabetes by site. Furthermore, we aimed at comparing excess risk according type, duration treatment, the latter as regards Type 2 diabetes.By use Reggio Emilia registry classified resident population aged 20-84 December 31st 2009 into two groups: diabetes. By linking calculated 2010-2013 both groups. The rate ratios (IRR) site, type diabetes, duration, concerns treatment regimen were computed using Poisson...
Abstract Bilirubin is neurotoxic upon excess accumulation in the brain, but it also plays important physiological roles related to its antioxidant properties. Here we report that exposure of PC12 and primary rat cerebellar granule neurons bilirubin (0.5–10 μM) drastically decreases nerve growth factor (NGF)/brain‐derived neurotrophic signaling Akt extracellular signal‐regulated kinases (ERKs), indicating a direct interference molecule with crucial prosurvival pathways. This effect likely...
Obesity and metabolic syndrome result from excess calorie intake genetic predisposition are mechanistically linked to type II diabetes accelerated body aging; abnormal nutrient insulin signaling participate in this pathologic process, yet the underlying molecular mechanisms incompletely understood. Mice lacking p66 kDa isoform of Shc adaptor molecule live longer leaner than wild-type animals, suggesting that may have a role derangement premature senescence by overnutrition. We found...
Myasthenia gravis (MG) is caused by autoantibodies targeting, in most cases, the acetylcholine receptor (AChR-MG). Different disease subtypes are distinguished on basis of clinical characteristics and thymus pathology. In 40% patients with anti-AChR negative generalized MG, appears to be mediated antibodies against muscle specific kinase (MuSK-MG).1 We evaluated HLA-DRB1*, DQA1*, DQB1* allele profile MuSK-MG comparison a control population non-thymoma early onset AChR-MG (AChR-EOMG). chose...
The objective of this study is to assess the impact diabetes on cardiovascular mortality, focusing sex differences. inhabitants Reggio Emilia province December 31, 2009, aged 20–84 were followed up for three years mortality. exposure was determined using register. age-adjusted death rates estimated as well incidence rate ratios Poisson regression model. Interaction terms and tested by Wald test. People with had an excess compared nondiabetic subjects (all cause: IRR = 1.68; 95%CI 1.60–1.78;...
Abstract Objectives About 10 million individuals in USA presented annually the emergency department (ED) with chest pain or signs and symptoms of acute coronary syndrome (ACS). The advent point care (POC) devices, able to measure high sensitivity troponin, are a very interesting tool ED setting for its rapid turnaround time (<10 min). Methods present study evaluates diagnostic performance Atellica VTLi (Siemens) real life using clinical data derived from integrated diagnoses room staff...
Aging | doi:10.18632/aging.100183. Emiliano Panieri, Gabriele Toietta, Marina Mele, Valentina Labate, Sofia Chiatamone Ranieri, Salvatore Fusco, Tesori, Annalisa Antonini, Giuseppe Maulucci, Marco De Spirito, Tommaso Galeotti, Giovambattista Pani
Carbapenemase-producing
Chest CT is a useful initial exam in patients with coronavirus disease 2019 (COVID-19) for assessing lung damage. AI-powered predictive models could be to better allocate resources the midst of pandemic. Our aim was build deep-learning (DL) model COVID-19 outcome prediction inclusive 3D chest images acquired at hospital admission. This retrospective multicentric study included 1051 (mean age 69, SD = 15) who presented emergency department three different institutions between 20th March 2020...
Hereditary breast and ovarian cancer (HBOC) syndrome is responsible for approximately 10% of cancers (BCs). The HBOC gene panel includes both high-risk genes, i.e., a four times higher risk BC (BRCA1, BRCA2, PALB2, CDH1, PTEN, STK11 TP53), moderate-risk two to (BARD1, CHEK2, RAD51C, RAD51D ATM). Pathogenic germline variants (PGVs) in genes confer an absolute that changes according the considered. We illustrate compare different estimation models, also describing their limitations. These...
To evaluate the in vitro activity of ceftazidime/avibactam, meropenem/vaborbactam, imipenem/relebactam and comparators against KPC-producing Klebsiella pneumoniae (KPC-Kp) clinical isolates collected from a multicentre study Italy (2022-23) genomic characterization molecular mechanisms causing resistance. Consecutive KPC-Kp blood cultures (n = 264) were 14 hospital centres period 2022-23. Antimicrobial susceptibility testing was performed using broth microdilution. WGS used to investigate...
Surgery in COVID-19 disease complicated by APF represents the last life-saving treatment option. The choice of therapeutic period to indicate this approach is fundamental. In fact, clinical stability patient necessary order allow single-lung ventilation and minimize postoperative sequelae.
Thymoma is an uncommon slowly growing neoplasm. It usually presents with paraneoplastic syndromes including the immunodeficiency syndrome called Good and hematological disorders. Pure red cell aplasia a well-recognized complication of thymoma, aplastic anemia very rare in association GS. We report case GS heavily treated patient stage IV thymoma associated pure amegakaryocytic thrombocytopenia that evolved into AA provide up-to-date review relevant literature. This first coexistence thymoma....
The rapid emergence of carbapenem-resistant Klebsiella pneumoniae ( Kp ) strains in diverse environmental niches, even outside the clinical setting, poses a challenge for detection and real-time monitoring novel antimicrobial resistance trends using molecular whole genome sequencing-based methods. aim our study was to understand cryptic determinants responsible phenotypic carbapenem observed circulating Italy by combined approach involving sequencing (WGS) genome-wide association (GWAS). In...
In this multicenter study (ISS 902), 554 previously untreated patients with <500 CD4 cells/mm3 and mildly symptomatic human immunodeficiency virus disease were randomized to receive zidovudine or didanosine (ddI). After a mean follow-up of 20 months, 80 (40 zidovudine, 40 ddI) had died 146 at least one AIDS-defining event (73 73 ddI). Overall, no difference was found between treatments respect progression AIDS death. The analysis relative risk (RR) over time, however, showed an initially...
Background: The study evaluates the role of a combined cytological smear (CS) and cell block (CB) approaches in malignant pleural effusion (MPE), highlighting specificity sensitivity referred to histology incidence different types malignancies. Methods: We retrospectively included 223 patients over duration 5 years. Pleural fluid was collected CS together with CB were made from fluid. Immunocytochemical (ICC) stains applied when requested by pathologist. Histology confirmation medical...