A5108045882- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Multiple Myeloma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Genomics and Chromatin Dynamics
- Telomeres, Telomerase, and Senescence
- Epigenetics and DNA Methylation
- Chronic Myeloid Leukemia Treatments
- Diabetes and associated disorders
- Bipolar Disorder and Treatment
- Retinoids in leukemia and cellular processes
- Celiac Disease Research and Management
- Microscopic Colitis
- Myasthenia Gravis and Thymoma
- Cutaneous lymphoproliferative disorders research
- Protein Degradation and Inhibitors
- Gastrointestinal disorders and treatments
- Iron Metabolism and Disorders
- Blood Coagulation and Thrombosis Mechanisms
- Blood disorders and treatments
- Phonocardiography and Auscultation Techniques
- Kruppel-like factors research
- Cardiac tumors and thrombi
- Salivary Gland Tumors Diagnosis and Treatment
University of Perugia
2013-2024
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
2020-2022
Istituti di Ricovero e Cura a Carattere Scientifico
2020-2022
Marche Polytechnic University
2018
Sapienza University of Rome
2015
Abstract Iron deficiency anemia is among the most frequent causes of disability. Intravenous iron quickest way to correct deficiency, bypassing bottleneck intestinal absorption, only true mechanism balance regulation in human body. administration suggested patients who are refractory/intolerant oral sulfate. However, intravenous requires several precautions; as in-hospital a resuscitation service, imposed Europe by European Medicine Agency, it very expensive and negatively affects patient’s...
GATA2 is a transcription factor with key roles in hematopoiesis. Germline gene variants have been associated several inherited and acquired hematologic disorders, including myelodysplastic syndromes. Among the spectrum of deficiency- manifestations thrombosis has reported 25% patients, but mechanisms are unknown. was shown to be involved endothelial nitric oxide synthase (eNOS) regulation vascular development. We assessed eNOS expression angiogenesis patients deficiency. Platelets blood...
Fetal phonocardiography (FPCG) is a non-invasive electronic recording of the acoustic cardiac signals.Unfortunately, FPCG hidden by high-amplitude noise which makes detection waveforms challenging.Aim study to propose PCG-Delineator as an algorithm for automatic first and second heart sound (S1 S2, respectively) from FPCG.To this aim, 37 simulated tracings (Physionet) are filtered wavelet-based procedure (4 th order Coiflets mother wavelet with 7 decomposition levels) erase...
Abstract Objective The most typical cytogenetic aberration in myelodysplastic syndromes is del(5q), which, when isolated, associated with refractory anaemia and good prognosis. Based on high rates of erythroid response transfusion independence, Lenalidomide ( LEN ) became the standard treatment. This multi‐centre study was designed to supplement Italian Registry data by addressing prescription, administration appropriateness, haematological responses disease evolution. Methods MORE an...
The unbalanced translocation dic(1;7)(q10;p10) in myelodysplastic syndromes (MDS) is originated by centromeric juxtaposition resulting into 1q trisomy and 7q monosomy. More than half of cases arise after chemo/radio-therapy. To date, given the absence genes within regions, no specific molecular events have been identified this cytogenetic subgroup. We performed first comprehensive genetic epigenetic analysis MDS with compared to normal controls therapy-related myeloid neoplasms (t-MNs)....
Thymoma is an uncommon slowly growing neoplasm. It usually presents with paraneoplastic syndromes including the immunodeficiency syndrome called Good and hematological disorders. Pure red cell aplasia a well-recognized complication of thymoma, aplastic anemia very rare in association GS. We report case GS heavily treated patient stage IV thymoma associated pure amegakaryocytic thrombocytopenia that evolved into AA provide up-to-date review relevant literature. This first coexistence thymoma....
ABSTRACT Jumping translocations (JT) are rare cytogenetic abnormalities associated with progression in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Typically, a tri–tetra‐somic 1q chromosome is translocated to two or more recipient chromosomes. In multiple myeloma JT were shown originate after DNA demethylation decondensation. Using epigenomics, we investigated sequential samples an SRSF2 ‐mutated MDS AML cohort normal karyotype at diagnosis 1qJT disease evolution...
This report is dealing with simultaneous diagnosis of Myelodysplastic Syndrome Excess Blasts 2 ( MDS ‐ EB 2) isolated 5q deletion and Smoldering Multiple Myeloma SMM ) typical changes, namely t (4;14) monosomy 13. I‐ FISH FICTION techniques showed distinct specific clones underlie the two hematological malignancies.
Background: Monosomy 7 is one of the most frequent aneuploidies in myeloid malignancies often occurring context high-risk Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML) associated to poor prognosis. Despite several studies have focused on pathogenetic role genes mapping at chromosome 7q, its molecular landscape remains undetermined. Aims: The aim this study was characterize biological features adult MDS/AML with isolated monosomy by investigating epi-genomic landscape....