A5017481279- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- HIV-related health complications and treatments
- HIV, Drug Use, Sexual Risk
- Long-Term Effects of COVID-19
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 Clinical Research Studies
- Gestational Diabetes Research and Management
- Tuberculosis Research and Epidemiology
- Pregnancy and Medication Impact
- Hepatitis C virus research
- Adolescent Sexual and Reproductive Health
- COVID-19 and healthcare impacts
- Syphilis Diagnosis and Treatment
- COVID-19 and Mental Health
- Pregnancy and preeclampsia studies
- Intensive Care Unit Cognitive Disorders
- Mycobacterium research and diagnosis
- Vaccine Coverage and Hesitancy
- Blood groups and transfusion
- Prenatal Screening and Diagnostics
- Parvovirus B19 Infection Studies
- Sex work and related issues
- Diagnosis and treatment of tuberculosis
Istituto Superiore di Sanità
2016-2025
Center for Global Health
2017-2025
Sapienza University of Rome
2020
Joint Clinical Research Centre
2018
Scuola Superiore Sant'Anna
2018
Libera Università Maria SS. Assunta
2018
Istituti di Ricovero e Cura a Carattere Scientifico
2006
Johns Hopkins University
2000
Boehringer Ingelheim (United Kingdom)
2000
University of Turin
1996
Abstract Background Aim of the present study is to describe characteristics COVID-19-related deaths and compare clinical phenotype course occurring in adults (<65 years) older (≥65 years). Method Medical charts 3,032 patients dying with COVID-19 Italy (368 aged < 65 years 2,664 ≥65 were revised extract information on demographics, preexisting comorbidities, in-hospital complications leading death. Results Older presented a higher number comorbidities compared those <65...
Abstract Background A significant proportion of individuals reports persistent clinical manifestations following SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection. Nevertheless, knowledge the burden this condition—often referred to as ‘Long COVID’—on health care system remains limited. This study aimed evaluate healthcare utilization potentially related Long COVID. Methods Population-based, retrospective, multi-center cohort that analyzed hospital admissions and...
Abstract Background Epidemiological data obtained during the initial wave of COVID-19 epidemic showed that persons dying with were typically older men multiple chronic conditions. No studies have assessed if characteristics patients changed in second phase epidemic, when subsided. The aim present study was to compare Italy first ‘peak’ and its phase. Methods Medical charts who died while hospital reviewed extract information on pre-existing comorbidities, in-hospital complications, disease...
A significant number of people, following acute SARS-CoV-2 infection, report persistent symptoms or new that are sustained over time, often affecting different body systems. This condition, commonly referred to as Long-COVID, requires a complex clinical management. In Italy health facilities specifically dedicated the diagnosis and care Long-COVID were implemented. However, activity these centers is highly heterogeneous, with wide variation in type services provided, specialistic expertise...
The prevalence and the genotypic phenotypic characteristics of multinucleoside-resistant (MNR) human immunodeficiency virus type 1 (HIV-1) variants in Europe were investigated a multicenter study that involved centers nine European countries. Study samples (n = 363) collected between 1991 1997 from patients exposed to two or more nucleoside analogue reverse transcriptase inhibitors (NRTIs) 274 control no one NRTI screened for marker mutations multinucleoside resistance (the Q151M mutation...
Tuberculosis is a major health concern in several countries, and effective diagnostic algorithms for use human immunodeficiency virus (HIV)-positive patients are urgently needed.At prescription of antiretroviral therapy, all 3 Mozambican centers were screened tuberculosis, with combined approach: World Health Organization (WHO) 4-symptom screening (fever, cough, night sweats, weight loss), rapid test detecting mycobacterial lipoarabinomannan urine (Determine TB LAM), molecular assay...
Abstract BACKGROUND Persons with Down syndrome (DS) are presumed to be at high risk of severe CoVID‐19, due immune dysregulation and often compromised cardiopulmonary function. Aim the present study is assess epidemiological clinical characteristics individuals DS deceased in Italian hospitals CoVID‐19. METHODS We used a nationwide database 3,438 patients RT‐PCR‐confirmed SARS‐CoV‐2 infection Italy (10.4% all deaths CoVID‐19 country time analysis). Data on demographics, pre‐existing...
Aims To compare steady‐state nelfinavir (NFV) pharmacokinetics in pregnant and nonpregnant HIV‐infected women. Methods Twenty‐five women were selected from an ongoing observational study evaluating the of antiretroviral agents during pregnancy. Twenty them third five second trimester. Data for control group 21 taken a previous multicentre pharmacokinetic trial. All participating achieved plasma concentrations while on highly active therapy (HAART) regimen including NFV (1250 mg bid) two...
Objective We used data from a national study of pregnant women with HIV to evaluate the prevalence congenital abnormalities in newborns infection. Design Observational study. Setting University and hospital clinics. Population Pregnant exposed antiretroviral treatment at any time during pregnancy. Methods The total birth defects was assessed on live births, stillbirths, elective terminations for fetal anomaly. associations between potentially predictive variables occurrence were expressed as...
To evaluate antiretroviral drug concentrations in mothers and infants enrolled under the Option B-Plus approach for prevention of HIV mother-to-child transmission Malawi to assess maternal virological response after 1 year treatment. Forty-seven women 25 children were studied. Mothers administered during pregnancy a combination tenofovir, lamivudine efavirenz continued it breastfeeding (up 2 years) thereafter. Drug evaluated (plasma breast milk) at 12 months post-partum (plasma) 6 age....
Abstract Background Among the unknowns posed by coronavirus disease 2019 (COVID-19) outbreak, role of biological sex to explain susceptibility and progression is still a matter debate, with limited sex-disaggregated data available. Methods A retrospective analysis was performed assess if differences exist in clinical manifestations transitions care among hospitalized individuals dying laboratory-confirmed SARS-CoV-2 infection Italy (February 27–June 11, 2020). Clinical characteristics times...
Abstract Serological studies in infants can provide valuable information on the degree of protection conferred by IgG maternal passive transfer during early life. If infant levels are inadequate, may be incomplete, increasing risk life-threatening diseases such as pertussis and measles, before immunization completion. In addition, HIV infection, -highly prevalent African countries like Malawi—may impair transplacental antibody transfer. We determined anti-Pertussis Toxin (PT) anti-measles 86...
The aim of the study was to describe recent trends in antiretroviral treatment late pregnancy and sociodemographic changes among pregnant women with HIV over last 6 years. Data from National Program on Surveillance Antiretroviral Treatment Pregnancy Italy were grouped per calendar year, treatment, population characteristics, maternal immunovirologic status newborn clinical parameters analyzed. A total 981 HIV-infected mothers who delivered between 2002 2008 evaluated. proportion receiving at...
Summary: The immunologic and virologic activity of nevirapine in combination with two nucleosides (zidovudine [ZDV] didanosine [ddI]) was evaluated antiretroviral-naive patients a CD4 count <200/mm3 or clinical AIDS. In all, 68 were enrolled 48-week double-blind, placebo-controlled trial. A group 32 received ZDV + ddI nevirapine, 36 ddI. Primary efficacy parameters the on HIV-1 RNA peripheral blood CD4+ cells, differences between groups analyzed by Wilcoxon's nonparametric two-sample test....
Objective To evaluate the effect of transmission category and demographic, clinical immunological characteristics on progression to AIDS survival zidovudine-treated patients. Design Prospective multicentre cohort study symptomatic non-AIDS Setting Eighty-three centres reporting data National Zidovudine Registry. Patients A total 1468 patients enrolled between July 1987 January 1991 were analysed. Main outcome measures Three-year AIDS-free probability estimates since therapy start. Cox...
We analysed the characteristics of pregnancies with a previously undetected HIV infection in national observational study pregnant women Italy. In total 443 available date diagnosis, 118 were characterized by (26·6%, 95% CI 22·5–30·8). The following factors independently associated this occurrence multivariate analysis (adjusted odds ratios; CIs): foreign nationality (5·1, 2·8–9·3); no pre-conception counselling (35·9, 4·8–266·1); first pregnancy (2·1, 1·2–4·0); asymptomatic status (6·8,...
Antiretroviral therapy is effective in reducing rates of mother-to child transmission HIV to low levels resource-limited contexts but the applicability and efficacy these programs field are scarcely known. In order explore such issues, we performed a descriptive study on retrospective data from hospital records HIV-infected pregnant women who accessed 2007-2010 Luanda Municipal Hospital service for prevention mother-to-child (PMTCT). The main outcome measure was infant survival transmission....