A5082576569- Frailty in Older Adults
- Chronic Disease Management Strategies
- Nutrition and Health in Aging
- Health Systems, Economic Evaluations, Quality of Life
- Long-Term Effects of COVID-19
- Pharmaceutical Practices and Patient Outcomes
- COVID-19 Clinical Research Studies
- Down syndrome and intellectual disability research
- Mitochondrial Function and Pathology
- Medical and Biological Ozone Research
- COVID-19 and healthcare impacts
- Geriatric Care and Nursing Homes
- Intensive Care Unit Cognitive Disorders
- Palliative Care and End-of-Life Issues
- Advanced Radiotherapy Techniques
- Intraperitoneal and Appendiceal Malignancies
- Ovarian cancer diagnosis and treatment
- Hydrogen's biological and therapeutic effects
- Cardiac Ischemia and Reperfusion
- Cancer survivorship and care
- Pharmacy and Medical Practices
- Gut microbiota and health
- Advanced MRI Techniques and Applications
- Metabolism and Genetic Disorders
- Antibiotic Use and Resistance
Azienda Unita' Sanitaria Locale Di Modena
2022-2025
Università Cattolica del Sacro Cuore
2016-2024
Agostino Gemelli University Polyclinic
2019-2022
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2021
Abstract Background Aim of the present study is to describe characteristics COVID-19-related deaths and compare clinical phenotype course occurring in adults (<65 years) older (≥65 years). Method Medical charts 3,032 patients dying with COVID-19 Italy (368 aged < 65 years 2,664 ≥65 were revised extract information on demographics, preexisting comorbidities, in-hospital complications leading death. Results Older presented a higher number comorbidities compared those <65...
People with Down Syndrome (DS) have a high prevalence of physical and psychiatric comorbidities experience early-onset dementia. With the outbreak CoVID-19 pandemic, strict social isolation measures been necessary to prevent spreading disease. Effects this lockdown period on behavior, mood cognition in people DS not assessed so far. In present clinical study, we investigated impact CoVID-19-related psychosocial, cognitive functional well-being sample population 46 adults DS. The interRAI...
Abstract BACKGROUND Persons with Down syndrome (DS) are presumed to be at high risk of severe CoVID‐19, due immune dysregulation and often compromised cardiopulmonary function. Aim the present study is assess epidemiological clinical characteristics individuals DS deceased in Italian hospitals CoVID‐19. METHODS We used a nationwide database 3,438 patients RT‐PCR‐confirmed SARS‐CoV‐2 infection Italy (10.4% all deaths CoVID‐19 country time analysis). Data on demographics, pre‐existing...
Abstract Background Among the unknowns posed by coronavirus disease 2019 (COVID-19) outbreak, role of biological sex to explain susceptibility and progression is still a matter debate, with limited sex-disaggregated data available. Methods A retrospective analysis was performed assess if differences exist in clinical manifestations transitions care among hospitalized individuals dying laboratory-confirmed SARS-CoV-2 infection Italy (February 27–June 11, 2020). Clinical characteristics times...
Sarcopenia is a syndrome characterized by the loss of skeletal muscle associated with reduced physical strength/performance and could be correlated depression, that most frequent cause emotional distress in old age can reduce quality life older adults. The aim present study to evaluate association between probable sarcopenia depressive symptoms adults, impact comorbidity frailty on this association. This cross-sectional included community-dwelling adults at their first geriatric evaluation....
Background Frailty, disability, and polypharmacy are prevalent in nursing home (NH) residents, often co-occurring with multimorbidity. There may be a complex interplay among them terms of outcomes such as mortality. Aims the study were to (i) assess whether residents (5–9 medications) or hyperpolypharmacy (≥10 drugs), have an increased risk death (ii) any association is modified by co-presence frailty disability. Methods Cohort longitudinal mortality data including 4,023 from 50 European 7...
Abstract Background Individuals with Down syndrome (DS) experience premature aging. Whether accelerated aging involves changes in body composition parameters and is associated early development of sarcopenia unclear. Aims To compare the prevalence between adults DS general population. Methods Body was assessed by whole-body dual-energy X-ray absorptiometry (DXA). Fat mass (FMI) skeletal indices (SMI) were calculated as ratio total fat appendicular lean square height, respectively....
Mitochondrial dysfunction is a relevant mechanism in cardiac aging. Here, we investigated the effects of late-life enalapril administration at non-antihypertensive dose on mitochondrial genomic stability, oxidative damage, and quality control (MQC) signaling hearts aged rats. The protein expression selected mediators (i.e., antioxidant enzymes, energy metabolism, biogenesis, dynamics, autophagy) was measured old rats randomly assigned to receive (n = 8) or placebo from 24 27 months age. We...
Abstract Data on clinical characteristics of adults with Down syndrome (DS) are limited and the phenotype these persons is poorly described. This study aimed to describe occurrence chronic diseases pattern medication use in a population DS. Participants were 421 community dwelling DS, aged 18 years or older. Individuals assessed through standardized protocol. Multimorbidity was defined as two more conditions polypharmacy concomitant five medications. The mean age participants 38.3 ± 12.8 214...
Abstract Background Most COVID-19-related deaths have occurred in older persons with comorbidities. Specific patterns of comorbidities related to COVID-19 not been investigated. Methods A random sample 6085 individuals Italy who died in-hospital confirmed between February and December 2020 were included. Observed expected (O/E) ratios disease pairs computed logistic regression models used determine the association O/E values ≥ 1.5. Results Six diseases exhibited 1.5 statistically significant...
Abstract: Breast cancer in commonly diagnosed older women. Older women are underrepresented clinical trials and evidence on the best treatment insufficient. Ageing is associated with increased number of comorbidities, polypharmacy, geriatric syndromes, as well progressive loss resilience to stressors, a phenomenon known frailty. The large variety characteristics within this population, together lack most suitable therapeutic approach limited data patients' preferences, make decision-making...
Abstract Background Down syndrome (DS) is characterised by premature ageing that affects selected organ systems, and persons with this condition can present patterns of co‐morbidities deficits often observed in the older population without DS. However, information on characteristics adult DS limited. The objective study to describe adults collected a standardised, comprehensive assessment instrument. Methods Cross‐sectional study. Four hundred thirty (age range 18/75 years) from three...
People with Down syndrome (DS) show lower bone mass density (BMD) and a higher prevalence of hypothyroidism compared to general population. Furthermore, DS is well-known high oxidative stress (OS) condition because genes involved in OS map on chromosome 21. Thyroid function too OS. Since both thyroid lead BMD osteoporotic fractures, we have explored correlations among BMD, hormones, parameters adults. A total 105 patients (48 males; 21-71 years; mean BMI 28.88±7.12 kg/m(2)) were enrolled...
Objective: Bevacizumab maintenance following platinum-based chemotherapy is an effective treatment for epithelial ovarian cancer (EOC), both in primary and recurrent disease.Our aim was to identify criteria select elderly patients who can safely benefit from bevacizumab addition.Methods: This a case-control study on with or EOC received plus bevacizumab, between January 2015 December 2016.Patient characteristics, details adverse events were reviewed analyzed 2 settings: younger (<65 years,...
Up to 26% of residents in nursing homes (NHs) are affected by cancer. Their care represents a challenge, because NHs not usually considered setting focused on oncologic management and care. The aim this paper is describe socio-demographic clinical features patients with cancer residing European NHs. Cross-sectional study based data from the Services Health for Elderly Long TERm (SHELTER) study. Participants were assessed through interRAI-LTCF, which includes assessment. Among 4140...