A5042964644- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Minimally Invasive Surgical Techniques
- Intraperitoneal and Appendiceal Malignancies
- Uterine Myomas and Treatments
- Renal cell carcinoma treatment
- Gynecological conditions and treatments
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Appendicitis Diagnosis and Management
- Inflammatory Biomarkers in Disease Prognosis
- Renal Diseases and Glomerulopathies
- Cancer-related Molecular Pathways
- Cervical Cancer and HPV Research
- COVID-19 and healthcare impacts
- Molecular Biology Techniques and Applications
- Cancer Immunotherapy and Biomarkers
- CRISPR and Genetic Engineering
- Female Genital Mutilation/Cutting Issues
- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- Hedgehog Signaling Pathway Studies
- PI3K/AKT/mTOR signaling in cancer
- Sexual function and dysfunction studies
- Gastric Cancer Management and Outcomes
Agostino Gemelli University Polyclinic
2016-2024
Università Cattolica del Sacro Cuore
2011-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2019
Recent evidence links aberrant activation of Hedgehog (Hh) signaling with the pathogenesis several cancers including medulloblastoma, glioblastoma, melanoma as well pancreas, colorectal, and prostate carcinomas. Here we investigated role transcription factor Gli1 in ovarian cancer. To this end, expression profile was examined normal ovaries, tumors, cancer cell lines, vitro effects a specific Hh-pathway blocker, KAAD-cyclopamine, or inhibitor (GANT58) on proliferation Hh target gene were...
Abstract Laboratory-markers of the systemic inflammatory-response, such as neutrophil/lymphocyte-ratio (NLR) have been studied prognostic factors in several tumors but OC-patients their role is still controversial and no data about possible correlation with BRCA-status has ever reported. We consecutively enrolled a series 397 newly diagnosed high-grade serous-advanced OC-patients. All patients were tested for BRCA-mutational-status blood-parameters collected 48 h before staging-surgery. A...
Objective: This study aimed to evaluate the potential advantages of laparoendoscopic single-site surgery (LESS) approach with respect conventional laparoscopy. Methods: Thirty LESS patients were matched 2:1 a previous cohort 58 undergoing laparoscopy for same type (controls). Results: Median operative time (38.5 vs 54 minutes; P = .09) and estimated blood loss (20 30 mL; .008) more favorable in treatment compared those Rupture cyst was observed 11 out cases (36.6%) 26 controls (44.8%; .46)....
Objective: Bevacizumab maintenance following platinum-based chemotherapy is an effective treatment for epithelial ovarian cancer (EOC), both in primary and recurrent disease.Our aim was to identify criteria select elderly patients who can safely benefit from bevacizumab addition.Methods: This a case-control study on with or EOC received plus bevacizumab, between January 2015 December 2016.Patient characteristics, details adverse events were reviewed analyzed 2 settings: younger (<65 years,...
Platinum-based chemotherapy plus bevacizumab is the new standard of care in stage IVB cervical cancer (CC) patients. In this scenario, radical surgery could be offered selected cases with an optimal clinical response. Potential surgical complications related to previous treatment have never been described before type setting.This a single-institutional retrospective study on women CC who received pelvic after platinum-based (platinum-taxol) bevacizumab.Between April 2016 and September 2017,...
<h3>Background</h3> During the COVID-19 pandemic, cancer care had to be reorganized; national and international recommendations were published manage anticancer treatments safely reduce risk of SARS-CoV-2 infection for patients health workers. <h3>Objective</h3> To evaluate whether adoption management with gynaecologic receiving treatment during pandemic resulted in containment infections continuing oncologic care. <h3>Methods</h3> Based on recommendations, according local Health Direction...
<h3>Introduction/Background</h3> Despite the majority of BRCA1/2 mutated (BRCA1/2mut) ovarian carcinoma (OC) experience remarkably prolonged survival, reason why some BRCA1/2mut carriers poor prognosis remains unclear, particularly for those patients who recurrence within 12 months following platinum-based chemotherapy. Furthermore, advent maintenance therapies from first-line settings, PARP inhibitors (PARPi), has shifted landscape relapse, potentially reducing incidence true...
In ovarian cancer, expression of metabolism-related markers has been investigated in several studies focusing on individual markers; however, a parallel quantitative evaluation mapping to distinct metabolic processes and their prognostic value large patient cohorts is still lacking.