A5101771080- Endometrial and Cervical Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Prostate Cancer Treatment and Research
- Abdominal Surgery and Complications
- Genetic factors in colorectal cancer
- Cervical Cancer and HPV Research
- Colorectal Cancer Treatments and Studies
- Ovarian cancer diagnosis and treatment
- Endometriosis Research and Treatment
- Gastric Cancer Management and Outcomes
- Renal cell carcinoma treatment
- Particle Detector Development and Performance
- Colorectal and Anal Carcinomas
- Respiratory Support and Mechanisms
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Radiation Detection and Scintillator Technologies
- Hormonal and reproductive studies
- Cancer Immunotherapy and Biomarkers
- Dark Matter and Cosmic Phenomena
- Renal and related cancers
- Estrogen and related hormone effects
- Cancer Risks and Factors
Agostino Gemelli University Polyclinic
2012-2025
Università Cattolica del Sacro Cuore
2013-2025
Massachusetts General Hospital
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2024
Istituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Frascati
2016-2024
University of Palermo
1990-2023
Health Net
2023
University of Catania
1982-2022
Sapienza University of Rome
1996-2022
Istituto Nazionale di Fisica Nucleare, Sezione di Roma I
2022
Abstract DNA methylation changes could provide a mechanism for plasticity and dynamism short‐term adaptation, enabling type of cell memory to register cellular history under different environmental conditions. Some insults may also result in pathological with corresponding alteration gene expression patterns. Evidence from several studies has suggested that schizophrenia bipolar disorder, mRNA the reelin ( RELN ), which encodes protein necessary neuronal migration, axonal branching,...
Small, noncoding RNAs are short untranslated RNA molecules, some of which have been associated with cancer development. Recently we showed that a class small generated during the maturation process tRNAs (tRNA-derived RNAs, hereafter "tsRNAs") is dysregulated in cancer. Specifically, uncovered tsRNA signatures chronic lymphocytic leukemia and lung demonstrated ts-4521/3676 cluster (now called "ts-101" "ts-53," respectively), ts-46, ts-47 down-regulated these malignancies. Furthermore, tsRNAs...
Dismutation of superoxide has been shown previously to be catalyzed by stable nitroxide compounds. In the present study, mechanism (.O2-) dismutation various five-membered ring and six-membered nitroxides was studied electron paramagnetic resonance spectrometry, UV-visible spectrophotometry, cyclic voltammetry, bulk electrolysis. Electron signals from carbocyclic derivatives (piperidinyl, pyrrolidinyl, pyrrolinyl) were unchanged when exposed enzymatically generated .O2-, whereas, in presence...
Abstract Purpose: Poly (ADP-ribose) polymerase (PARP) inhibitors are undergoing clinical evaluation for cancer therapy. Because PARP inhibition has been shown to enhance tumor cell sensitivity radiation, we investigated the in vitro and vivo effects of novel inhibitor E7016. Experimental Design: The effect E7016 on radiosensitivity lines was evaluated using clonogenic survival. DNA damage repair were measured γH2AX foci neutral comet assay. Mitotic catastrophe determined by immunostaining....
Abstract Editor’s Perspective What We Already Know about This Topic Article Tells Us That Is New Background Airway closure causes lack of communication between proximal airways and alveoli, making tidal inflation start only after a critical airway opening pressure is overcome. The authors conducted matched cohort study to report the existence this phenomenon among obese patients undergoing general anesthesia. Methods Within procedures clinical trial during gynecological surgery, underwent...
To date, robotic surgery in urology is well established all over the world. The newest platform on market HUGO™ RAS system, developed by Medtronic. In this paper we provide a brief description of system and describe our set-up surgical approach with new initial experience radical prostatectomy (RARP) series.After an official training, seven consecutive patients affected localized prostate cancer underwent RARP HUGOTM at Institution. A docking setup provided. Docking console times were...
Background: Robotic-assisted surgery is the gold standard for performing radical prostatectomy (RARP), with new robotic devices such as HugoTM RAS gaining prominence worldwide. Objective: We report surgical, perioperative, and early postoperative outcomes of RARP using RAS. Design, setting, participants: Between April 2022 October 2023, we performed 132 procedures Montsouris technique a four-robotic-arm configuration in patients biopsy-proven prostate cancer (PCa). Outcome measures:...
The protective effect of stable nitroxide radicals against oxidative damage was studied using cardiomyocyte cultures obtained from newborn rats. Monolayered cardiomyocytes were exposed to H2O2 and the on spontaneous beating leakage LDH determined. Hydrogen peroxide irreversibly blocked rhythmic resulted in a significant membrane injury as shown by release LDH. prevented catalase which removes cell-permeable, metal-chelating agents such desferrioxamine or bipyridine. In contrast, reagents are...
Abstract Promoter DNA methylation status of six genes in samples derived from 27 bronchial epithelial cells and matching blood 22 former/current smokers five nonsmokers as well 49 primary non–small cell lung cancer with corresponding controls was determined using methylation-specific PCR (MSP). Lung tumor tissues showed a significantly higher frequency promoter p16, MGMT, DAPK (P < 0.05; Fisher's exact test). p16 tumors observed at consistently levels when compared all the other...
HIF1α and NFkB are two transcription factors very frequently activated in tumors involved tumor growth, progression, resistance to chemotherapy. In fact, together regulate of over a thousand genes that, turn, control vital cellular processes such as adaptation the hypoxia, metabolic reprograming, inflammatory reparative response, extracellular matrix digestion, migration invasion, adhesion, etc. Because this wide involvement they could an integrated manner origin malignant phenotype....
Early identification of mutations may guide patients with metastatic colorectal cancer toward targeted therapies that be life prolonging. The authors assessed tumor genotype correlations clinical characteristics to determine whether mutational profiling can account for similarities, differences, and outcomes.Under Institutional Review Board approval, 222 colon adenocarcinoma (n = 158) rectal 64) who underwent genotyping were reviewed. Multiplexed screened >150 across 15 commonly mutated...
Abstract Vorinostat (suberoylanilide hydroxamic acid), a histone deacetylase inhibitor, is currently undergoing clinical evaluation as therapy for cancer. We investigated the effects of vorinostat on tumor cell radiosensitivity in breast cancer brain metastasis model using MDA-MB-231-BR cells. In vitro was evaluated clonogenic assay. Cell cycle distribution and apoptosis measured flow cytometry. DNA damage repair γH2AX. Mitotic catastrophe by immunostaining. Growth delay intracranial...
We designed a retrospective study to assess the surgical and economic outcomes of robot-assisted laparoscopic pyeloplasty (RALP) compared with open (OP), including consecutive patients suffering from ureteropelvic junction obstruction operated on January 2012 2022 at single center. Preoperative, intraoperative, postoperative outcomes, costs, were comparatively analyzed. The primary outcome was 3-month success, defined as symptom resolution no upon diuretic renal scintigraphy. Overall, 91...
The role of tumor cells in synthesizing pro‐inflammatory molecules is still controversial. Here we report that hypoxic treatment the MCF‐7 human mammary adenocarcinoma cell line induced activation hypoxia‐inducible factor 1α (HIF‐1α) and nuclear factor‐kappa B (NF‐κB). Importantly, hypoxia regulated expression alarmin receptors such as receptor for advanced glycation end products (RAGE) purinoreceptor (P2X7R), up‐regulated inflammatory response (IR) genes inducible enzymes nitric oxide...
Multidimensional genotyping of formalin-fixed paraffin-embedded (FFPE) samples has the potential to improve diagnostics and clinical trials for brain tumors, but prospective use in setting is not yet routine. We report our experience with implementing a multiplexed copy number mutation-testing program diagnostic laboratory certified by Clinical Laboratory Improvement Amendments. collected analyzed testing results from whole-genome array comparative genomic hybridization (OncoCopy) 420...
Abstract BACKGROUND Recent studies have underlined the role of tumor cells in endogenous synthesis pro‐inflammatory molecules. We tested whether malignant progression prostate cancer was associated with activation a phenotype typical innate immune system. METHODS The expression set molecules involved tissue inflammation and repair measured by real‐time PCR Western blot analysis samples absence or slight presence detectable leukocyte infiltrate. Whole non‐tumor were analyzed addition to...