A5014873864- Acute Myeloid Leukemia Research
- Retinoids in leukemia and cellular processes
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Eosinophilic Disorders and Syndromes
- Advanced biosensing and bioanalysis techniques
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Antioxidant Activity and Oxidative Stress
- Estrogen and related hormone effects
- Protein Degradation and Inhibitors
- Multiple Myeloma Research and Treatments
- RNA Interference and Gene Delivery
- Hematopoietic Stem Cell Transplantation
- Biotin and Related Studies
- Nuclear Structure and Function
- Cell death mechanisms and regulation
- DNA and Nucleic Acid Chemistry
- Drug-Induced Ocular Toxicity
- MicroRNA in disease regulation
- Sarcoma Diagnosis and Treatment
- Kruppel-like factors research
- Ocular Oncology and Treatments
- Epigenetics and DNA Methylation
Policlinico Umberto I
2016-2025
Sapienza University of Rome
2013-2025
Hospital Universitari Germans Trias i Pujol
2019
University of Rome Tor Vergata
2005-2009
King's College London
2009
Royal Liverpool University Hospital
2009
University of Liverpool
2009
University of Wales
2009
Guy's Hospital
2009
University College London
2009
Nucleophosmin (NPM), a nucleocytoplasmic shuttling protein with prominent nucleolar localization, regulates the ARF-p53 tumor-suppressor pathway. Translocations involving NPM gene cause cytoplasmic dislocation of protein.We used immunohistochemical methods to study subcellular localization in bone marrow-biopsy specimens from 591 patients primary acute myelogenous leukemia (AML). We then correlated presence clinical and biologic features disease.Cytoplasmic was detected 208 (35.2 percent)...
Acute myeloid leukemia (AML) carrying NPM1 mutations and cytoplasmic nucleophosmin (NPMc+ AML) accounts for about one-third of adult AML shows distinct features, including a unique gene expression profile. MicroRNAs (miRNAs) are small noncoding RNAs 19-25 nucleotides in length that have been linked to the development cancer. Here, we investigated role miRNAs biology NPMc+ AML. The miRNA was evaluated 85 de novo patients characterized subcellular localization/mutation status FLT3 using custom...
Molecular diagnostics and early assessment of treatment response that use methodologies capable detecting submicroscopic disease can distinguish subgroups patients with leukemia at differing relapse risk. Such information is being incorporated into risk-stratified protocols; however, there are few data concerning prospective sequential minimal residual (MRD) monitoring to identify more precisely those destined experience relapse, which would allow tailored therapies.Real-time quantitative...
Although acute promyelocytic leukemias (APLs) are consistently associated with a reciprocal chromosome 15;17 translocation, the gene(s) directly affected by breakpoints have never been isolated. The 17 breakpoint maps to near retinoic acid receptor alpha (RAR alpha) locus. Investigation of 20 APLs and large series other neoplastic patients normal controls revealed RAR gene rearrangements aberrant transcripts only in APL cases. These findings suggest that is involved breakpoint, implicated...
Acute promyelocytic leukaemia (APL), characterized by a specific PML‐RARα fusion gene resulting from translocation t(15;17) and high response rate to differentiation therapy with all‐ trans retinoic acid, presents clinical (varying WBC counts, age treatment outcome), morphological (hypergranular M3 hypogranular M3V) molecular (three isoforms of PML breakpoint) heterogeneity. We correlated leukaemic immunophenotype these aspects in 196 molecularly confirmed APLs (63 children 133 adults)...