Luca Stingeni
A5037063477- Contact Dermatitis and Allergies
- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Drug-Induced Adverse Reactions
- Psoriasis: Treatment and Pathogenesis
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Asthma and respiratory diseases
- Occupational exposure and asthma
- Food Allergy and Anaphylaxis Research
- Nail Diseases and Treatments
- Entomological Studies and Ecology
- Dermatological diseases and infestations
- Insect and Pesticide Research
- Study of Mite Species
- Mast cells and histamine
- Pharmaceutical studies and practices
- Chemotherapy-related skin toxicity
- Autoimmune and Inflammatory Disorders
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cutaneous lymphoproliferative disorders research
- Cutaneous Melanoma Detection and Management
- Skin Diseases and Diabetes
- Pharmacovigilance and Adverse Drug Reactions
- Eosinophilic Disorders and Syndromes
University of Perugia
2016-2025
Manchester University NHS Foundation Trust
2023
San Gallicano Hospital
2021
Ospedale Santa Maria
2021
Agostino Gemelli University Polyclinic
2020
Michigan United
2020
University of Bari Aldo Moro
2008
This update and revision of the international guideline for urticaria was developed following methods recommended by Cochrane Grading Recommendations Assessment, Development Evaluation (GRADE) working group. It is a joint initiative Dermatology Section European Academy Allergology Clinical Immunology (EAACI), Global Allergy Asthma Network (GA²LEN) its Urticaria Angioedema Centers Reference Excellence (UCAREs ACAREs), Forum (EDF; EuroGuiDerm), Asia Pacific Association Allergy, with...
Chronic spontaneous urticaria (CSU) is defined as occurrence of wheals and/or angioedema for ≥6 weeks. Omalizumab a monoclonal anti-IgE antibody effective in refractory CSU, but its mechanism action and markers predictive response remain not completely defined.To correlate baseline levels two proposed biomarkers, total IgE (bIgE) d-dimer (bd-dimer), clinical parameters to omalizumab relapses after drug withdrawal.In this retrospective Italian multicentre study, data were collected 470 CSU...
Patch testing is the standard procedure used to diagnose allergic contact dermatitis. It an in-vivo test, which reproduces reaction a allergen. This test aims reproduce elicitation phase of dermatitis and performed applying allergens under occlusion on skin standardized conditions. These guidelines for best practice in performing patch have been developed by Italian group experts taking account legislation local pharmacological governance. Guidelines are adapted from original article...
Dupilumab, a fully human monoclonal antibody targeting the alpha subunit of IL-4 was recently approved for treatment moderate-to-severe atopic dermatitis (AD) in adult patients.To assess dupilumab effectiveness and safety adults with AD real-life Italian multicentre retrospective cohort.Adult patients, referring to 39 centers, received context national patient access program. Disease assessment performed at baseline, after 4 16 weeks using Eczema-Area-and-Severity-Index (EASI) score, itch...
Treatment of moderate-to-severe atopic dermatitis (AD) in the elderly may be challenging, due to side-effects traditional anti-inflammatory drugs and comorbidities often found this age group. Furthermore, efficacy safety innovative such as dupilumab are not yet well known.A multicentre retrospective, observational, real-life study on was conducted a group patients aged ≥65 years affected by severe AD. Their main clinical features were also examined.Data with (EASI ≥24) AD treated at label...
SIDeMaST (Società Italiana di Dermatologia Medica, Chirurgica, Estetica e delle Malattie Sessualmente Trasmesse) contributed to the development of present guideline on systemic treatment chronic plaque psoriasis. With permission EuroGuiDerm, adapted Italian healthcare context supply a reliable and affordable tool physicians who take care patients affected by moderate severe The content includes general information scope purpose, health questions covered, target users strength/limitations...
Continual analyses of patch test results with the European baseline series (EBS) serve both contact allergy surveillance and auditing value included allergens.To present current EBS testing, obtained in 53 departments 13 countries during 2019 2020.Anonymised or pseudonymised individual data partly aggregated on demographic/clinical characteristics rest were prospectively collected centrally pooled analysed.In 2020, 22 581 patients tested EBS. Sensitization to nickel remained most common...
Moderate-to-severe atopic dermatitis (AD) in the adolescence is a high burden disease, and its treatment can be very challenging due to paucity of approved systemic drugs for this age their side-effects. Dupilumab was recently adolescent AD.A multicentre, prospective, real-world study on effectiveness safety dupilumab adolescents (aged from ≥12 <18 years) with moderate-to-severe AD conducted. The main clinical phenotypes were also examined.Data treated at label dosage 16 weeks collected....
Occupational skin diseases have led the occupational disease statistics in Europe for many years. Especially allergic contact dermatitis is associated with a poor prognosis and low healing rates leading to an enormous burden affected individual society.To present sensitization frequencies most relevant allergens of European baseline series patients (OCD) compare profiles different occupations.The data 16 022 considered having OCD after patch testing within Surveillance System on Contact...
Janus kinase (JAK) inhibitors, including upadacitinib, have been recently approved for the treatment of moderate-severe atopic dermatitis (AD) and real-world data on upadacitinib effectiveness safety are limited. This interim analysis aimed to assess throughout 48 weeks observation in a adult AD population. prospective study collected patients affected by moderate-to-severe treated with at dosage either 15 mg or 30 daily based physician decision. Upadacitinib was prescribed context national...
Alopecia areata (AA) is an organ-specific autoimmune disorder that targets anagen phase hair follicles.The course unpredictable and current available treatments have variable efficacy.Nowadays, there relatively little evidence on treatment of AA from well-designed clinical trials.Moreover, none the or devices commonly used to treat are specifically approved by Food Drug Administration.The italian Study Group for Cutaneous annexial disease Society dermatology proposes these guidelines diagnosis
Treat-to-target strategies are used in several chronic diseases to improve outcomes. Treatment goals have also been suggested for psoriasis, but there is currently no consensus on targets, and guidance needed implement this strategy clinical practice. The project 'Treat Target Italia' was launched by a scientific board (SB) of 10 psoriasis experts generate expert recommendations. On the basis published literature, their experience, results survey among Italian dermatologists, SB identified...
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by recurrent eczematous lesions and intense pruritus. AD patients are known to face considerable burden, including physical emotional limitations. There still limited knowledge about daily implications in education occupation. We describe social stigmatization measuring bullying self-isolation students professional discrimination workers. Overall loss of productivity, either at school the workplace, was quantified as...
Abstract Background Eyelid dermatitis is a frequent reason of dermatological consultation. Its aetiology not univocal, being contact dermatitis, both allergic and irritant, the most frequent. The primary sources allergen exposure include cosmetics, metals, topical medications, from direct, indirect, or airborne contact. Objectives To define frequency positive patch test reactions to SIDAPA baseline series allergens, document precise final diagnosis in patients with eyelid involvement....
Summary Background The evidence on the safety of topical preparations containing botanical extracts is limited. Objectives To assess (i) use botanically derived compounds in a large population, (ii) incidence cutaneous side‐effects, and (iii) diagnostic usefulness patch testing. Methods A questionnaire was used 2661 patients to both prevalence type used, occurrence adverse skin reactions. Patients declaring reactions were tested with I talian ( SIDAPA ) baseline series, an additional...
Summary Background The prevalence of occupational and non‐occupational textile dermatitis seems to be increasing, probably because changed manufacturing techniques. Objective Evaluation the clinical features epidemiology contact ( TCD ) in I taly. Methods Demographic data, history aspects, atopy positive patch test reactions allergens were investigated 277 patients. Results Contact was most frequent presentation (95.3%). more common females, fourth fifth decades life, atopic lesions...