A5084285371- Nonmelanoma Skin Cancer Studies
- Cutaneous lymphoproliferative disorders research
- Dermatology and Skin Diseases
- Cutaneous Melanoma Detection and Management
- Autoimmune Bullous Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Skin Protection and Aging
- Nail Diseases and Treatments
- Hair Growth and Disorders
- Genetic and rare skin diseases.
- Urticaria and Related Conditions
- Cancer and Skin Lesions
- Dermatologic Treatments and Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Contact Dermatitis and Allergies
- melanin and skin pigmentation
- Food Allergy and Anaphylaxis Research
- T-cell and B-cell Immunology
- Skin and Cellular Biology Research
- Chemotherapy-related skin toxicity
- Allergic Rhinitis and Sensitization
- RNA regulation and disease
- Infectious Diseases and Mycology
- Asthma and respiratory diseases
- Oral Health Pathology and Treatment
Policlinico Tor Vergata
2015-2025
University of Rome Tor Vergata
2015-2024
Weatherford College
2020
Kraftanlagen (Germany)
2018
Berlin Heart (Germany)
2018
Praxis
2018
Ludwig-Maximilians-Universität München
2006-2009
Abstract Tonsillar infection with Streptococcus pyogenes may induce several nonsuppurative autoimmune sequelae. The precise pathogenetic mechanisms behind this clinically well-established association are still unresolved. Using TCR analysis, we sought to identify a link between streptococcal tonsillitis and the T cell-mediated response in psoriasis. Three patients streptococcal-induced psoriasis underwent tonsillectomy. size spectratyping sequencing of β-chain variable region gene (TCRBV)...
Abstract Background Alopecia areata is an autoimmune condition characterized by rapid hair loss in the scalp, eyebrows and eyelashes, for which treatments are limited. Baricitinib, oral inhibitor of Janus kinases 1 2, has been recently approved to treat alopecia areata. Materials Methods We conducted a retrospective study involving 23 medical centres across Italy, enrolling patients affected severe (SALT >50), more than 6 months. Clinical trichoscopic assessment was performed at each...
Abstract Chronic spontaneous urticaria (CSU) is a persistent skin condition characterised by itchy wheals, angioedema, or both, significantly impacting patients’ quality of life. The absence identifiable triggers makes diagnosis, monitoring, and management particularly challenging. Patient-reported outcomes (PROs) are direct reports from patients that offer valuable insights into their health well-being, enhancing communication between clinicians enabling more personalised care informed...
Nail psoriasis occurs in 7% to 40% of children, with a similar pattern clinical presentation that adults. In 0.6% 2.3% the patients nail changes appear as only sign disease, preceding other skin and articular involvement. No pediatric trials are available yet, but considering successful use tazarotene for dystrophy therapy adults, we chose this drug treat child.
Psoriasis is a chronic inflammatory disorder of the skin characterized by epidermal hyperplasia and infiltration leukocytes into dermis epidermis. T cell-derived cytokines, such as IFN-γ IL-17A, play major role in psoriasis-associated hyperplasia, even though factors/mechanisms that regulate production these cytokines are not fully understood. We have recently shown IL-21 synthesized excess psoriatic lesions causes when injected intradermally mice. Moreover, human psoriasis SCID mouse model,...
The cases are reported of two women patients presenting asymptomatic solitary lesions: one in the anterior tibial region right leg, other on arm. first patient's lesion was 3 cm diameter and had appeared 2 years earlier as a translucent oval atrophic patch with definite border. second patient presented whitish area lilac ring, 2.5 diameter, which nearly year earlier. Both no similar cutaneous lesions, their family histories for disease were negative. lesions underwent punch biopsy,...
Cyclooxygenase (COX) 1 and 2 enzyme up-regulation is involved in the pathogenetic process of actinic keratosis (A.K.) non-melanoma skin cancers. Diclofenac, a non-steroidal anti-inflammatory (N.S.A.I.D.) drug, used as topical treatment A.K. Piroxicam N.S.A.I.D. characterized by high COX-1 inhibition activity.We conducted an 18 month exploratory open-label study on A.K., to assess efficacy tolerability new formulation piroxicam sunscreen A.K.Enrolled subjects applied galenic 0.8%, vehiculated...
Distal and lateral onychomycoses are the most frequent forms of onychomycosis, causing subungual hyperkeratosis that usually limits local penetration antimycotic drugs. Tazarotene exerts anti-inflammatory immune-modulating activities toward both infective agents damaged keratinocytes. Given well-documented efficacy tazarotene on hyperkeratotic nail psoriasis, we investigated its therapeutic use in onychomycosis.We designed a preliminary open clinical trial patients affected by distal...
Organ transplant recipient (OTR) subjects are at high risk of skin cancer such as squamous cell carcinoma and basal carcinoma. Actinic keratosis (AK) is considered the precursor these non-melanoma cancers. Sun protection mandatory in with AK this preventive strategy very important OTR. Treatment field cancerization also crucial to reduce recurrence lesions patients. Activation cyclooxygenase 1 2 enzymes plays an role pathogenesis Topical application inhibitors diclofenac and, more recently,...
Sunscreen protection in subjects with actinic keratosis (AK) is highly recommended to prevent clinical evolution of this situ skin cancer condition. Use topical anti-cyclooxygenase drugs such as diclofenac and piroxicam reduces the number lesions improves cancerization field. A film-forming medical device a cream formulation containing organic inorganic sun-filters (50+ SPF) 0.8% (ACTX) has shown pilot, single-center, open trial reduce AK improving field.We evaluated multicenter,...
Patients who respond only partially to etanercept may require additional treatments that act synergistically improve their therapeutic response while at the same time reducing dose required and risk of side-effects. The aim this study was evaluate effecti veness topical calcipotriol in partial responder patients. We enrolled 120 patients affected by psoriasis vulgaris psoriatic arthritis. A 50 mg administered twice weekly for first 12 weeks, followed a 25 an weeks. At week 12, 45 had not...
Hereditary syndromes frequently need the cooperation of different specialties to increase diagnostic competence. Multiple cutaneous and uterine leiomyomatosis syndrome is a rare autosomal dominant disorder caused by mutations fumarate hydratase gene, demonstrated in 80 100 percent affected individuals. This can be linked an increased risk renal cancer both sexes. The skin involvement described highlight role counterpart identifying this syndrome. A 37-year-old woman suffering from several...
Actinic keratosis (AK) is considered as superficial squamous cell carcinoma. Chronic sun exposure plays a central role in its pathogenesis. In particular, ultraviolet B radiation causes direct damage to the DNA, producing pyrimidine dimers that suppress protective of p53. Other risk factors include advanced age, male sex, and fair skin type. Even some drugs used for treating blood hypertension, such thiazide diuretics, can increase developing AK. Their photosensitizing action seems be...
Basal cell carcinoma is the most common non-melanoma skin cancer, and its incidence continues to raise. Although surgery can be considered mainstay of therapy, new current pharmacological options are available focus on tumor eradication, maximizing cosmetic results, functional capacity. Several studies have recently reported safety efficacy topical ingenol mebutate gel, a derivative plant Euphorbia Peplus, used treat actinic keratosis superficial basal carcinoma. In our knowledge, we report...
Psoriasis is a common chronic skin disease, associated with an important physical and physiological involvement for any age. There strong link between psoriasis streptococcal infection, particularly that of the tonsils. are many therapies to treat including topical, systemic, biologic agents but these treatments not free from side effects. Streptococcus salivarius K-12 oral probiotic product useful prophylaxis treatment tonsillar infections in children adults, now tested here first time...