A5006307929- Cutaneous Melanoma Detection and Management
- Nonmelanoma Skin Cancer Studies
- Cutaneous lymphoproliferative disorders research
- Cancer and Skin Lesions
- Nail Diseases and Treatments
- Melanoma and MAPK Pathways
- Genetic and rare skin diseases.
- Hedgehog Signaling Pathway Studies
- Infectious Diseases and Mycology
- Skin Protection and Aging
- Tumors and Oncological Cases
- Genital Health and Disease
- CAR-T cell therapy research
- melanin and skin pigmentation
- Immunotherapy and Immune Responses
- Autoimmune Bullous Skin Diseases
- Dermatologic Treatments and Research
- Vascular Tumors and Angiosarcomas
- Autoimmune and Inflammatory Disorders
- MicroRNA in disease regulation
- Chemotherapy-related skin toxicity
- Psoriasis: Treatment and Pathogenesis
- AI in cancer detection
- Sarcoma Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
University of Bologna
2016-2025
Azienda USL di Bologna
2020-2025
Policlinico S.Orsola-Malpighi
2015-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2021-2023
Oxfam
2023
Liechtenstein Institute
2023
John Wiley & Sons (United States)
2023
Hudson Institute
2023
John Wiley & Sons (United Kingdom)
2023
University of Rome Tor Vergata
2020
BackgroundThe SafeTy Events in VIsmodEgib study (STEVIE, ClinicalTrials.gov, NCT01367665), assessed safety and efficacy of vismodegib—a first-in-class Hedgehog pathway inhibitor demonstrating clinical benefit advanced basal cell carcinoma (BCC)—in a patient population representative practice. Primary analysis data are presented.Patients methodsPatients with locally or metastatic BCC received oral vismodegib 150 mg/d until progressive disease, unacceptable toxicity, withdrawal. objective was...
Aging | doi:10.18632/aging.100654. Gianluca Sgarbi, Paola Matarrese, Marcello Pinti, Catia Lanzarini, Barbara Ascione, Lara Gibellini, Emi Dika, Annalisa Patrizi, Chiara Tommasino, Miriam Capri, Andrea Cossarizza, Alessandra Baracca, Giorgio Lenaz, Giancarlo Solaini, Claudio Franceschi, Walter Malorni, Stefano Salvioli
Alopecia areata (AA) is an organ-specific autoimmune disorder that targets anagen phase hair follicles.The course unpredictable and current available treatments have variable efficacy.Nowadays, there relatively little evidence on treatment of AA from well-designed clinical trials.Moreover, none the or devices commonly used to treat are specifically approved by Food Drug Administration.The italian Study Group for Cutaneous annexial disease Society dermatology proposes these guidelines diagnosis
Tumor growth and metastatic spreading are heavily affected by the P2X7 receptor as well microvesicles exosomes release into tumor microenvironment. stimulation is known to trigger vesicular from immune central nervous system cells. However, role in delivery cells was never analyzed depth. Here we show that overexpressed patients malignant melanoma its expression closely correlates with reduced overall survival. Antagonism of cell-expressed inhibited vitro anchorage-independent migration vivo...
Subungual squamous cell carcinoma (SSCC) is the most common malignancy of nail unit. Mohs micrographic surgery (MMS) a microscopically controlled surgical technique that has high cure rate for skin cancers despite allowing narrow margins.To evaluate long-term effectiveness MMS in treatment SSCC, and particular its ability to reduce number digital amputations.Fifteen patients diagnosed with SSCC were treated as first-line approach, followed up between 2 5 years.SSCC was completely excised 13...
Syphilitic alopecia (SA) is mainly described in single case reports, and there are only a few epidemiological studies.To investigate the clinical dermoscopic features of SA patients with secondary syphilis to record its actual prevalence.All diagnosis were clinically trichoscopically evaluated search hair scalp alterations.Five 12 (41.6%) diagnosed had SA. The 'moth-eaten' pattern was detected 4 (80% cases): 1 'essential' SA, whereas 3 'symptomatic' 'diffuse' found patient. Trichoscopy areas...
Squamous cell carcinoma (SCC) is the most frequent malignant tumor of nail unit.The aim this study was to review long-term outcome patients affected by SCC who underwent Mohs surgery.Patients were enrolled, including cases where x-ray examination had revealed bone changes. The completely excised and defect filled with a skin substitute based on hyaluronic acid involvement not observed. Where sections indicated involvement, distal phalanx disarticulated remaining end digit repaired using...
Ipilimumab is an immunomodulatory antibody directed against cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), which administered to patients with advanced melanoma, a proven positive effect on overall survival. The cutaneous adverse effects (AEs) of ipilimumab are relatively frequent, although described as usually mild and rarely life threatening. To describe three-year experience single institute in detecting managing AEs. A cohort (n = 41) treated (3 mg/kg/three weeks) for metastatic...
Several options for the treatment of ingrowing toenails are available, ranging from simple conservative approaches to extensive surgical procedures.To evaluate in a long-term follow-up (36 months) efficacy chemical matricectomy with phenol toenails.A total 197 ablations were performed 139 patients stage 2 and 3 disease. Each patient was examined weekly until full wound healing achieved followed 36 months assess treatment. The period after surgery ranged 4 weeks; few postoperative...
Marco Vincetia, Carlotta Malagolia, Chiara Fiorentinib, Caterina Longob, Catherine M. Crespic, Giuseppe Albertinid, Cinzia Riccid, Anna Lanzonie, Maurizio Reggianie, Annarosa Virgilif, Federica Ostif, Mara Lombardig, Marcello Santinig, Pier Alessandro Fantih, Emi Dikah, Sabina Sierii, Vittorio Kroghi, Stefania Seidenarib & Giovanni Pellacanib a Center for Environmental, Genetic, and Nutritional Epidemiology CREAGEN, Department of Public Health Sciences , University Modena Reggio Emilia...
Nail apparatus melanoma (NAM) is an uncommon tumor, especially in Caucasians. The prognosis of patients affected by NAM was analyzed and correlated with the histopathological criteria surgical management tumors.We collected data regarding referred to Skin Cancer Unit Dermatology Department University Bologna, from 1992 January 2012.Out 1,327 cases diagnosed between 2012, 42 were (2.93%). All Caucasian. Two deceased insufficient medical records 1 woman a personal history breast cancer...
Targeted therapies for melanoma have shown clinical benefit in increasing the survival of metastatic patients. Cutaneous adverse events been reported, but hair and nail data rarely detailed. Patients treated with BRAF MEK inhibitors underwent dermatological evaluation before start each treatment after every four weeks. Pull test, global photography, dermoscopy/trichoscopy scalp biopsy were performed. Appendages graded using National Cancer Institute's Common Terminology Criteria. Of 24...