A5081257602- Cancer-related Molecular Pathways
- Acne and Rosacea Treatments and Effects
- Breast Cancer Treatment Studies
- melanin and skin pigmentation
- HER2/EGFR in Cancer Research
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- RNA modifications and cancer
- Breast Lesions and Carcinomas
- Sarcoma Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Lung Cancer Research Studies
- Genetic factors in colorectal cancer
- Nail Diseases and Treatments
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Metastasis and carcinoma case studies
- Medical Imaging and Pathology Studies
- AI in cancer detection
University of Trento
2009-2025
Provincia Autonoma di Trento
2001-2025
Ospedale Santa Chiara
2015-2024
University of Milan
2001-2024
Trenitalia (Italy)
2019-2023
University of Milano-Bicocca
2023
Molecular Oncology (United States)
2021
Presidio Ospedaliero
2019
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
1997-2019
University of Verona
1994-2018
PURPOSE To determine the absolute and relative value of microvessel density (MVD), p53 c-erbB-2 protein expression, peritumoral lymphatic vessel invasion (PLVI), conventional prognosticators in predicting relapse-free (RFS) overall survival (OS) rates patients with node-negative breast carcinoma (NNBC). PATIENTS AND METHODS We monitored 254 consecutive NNBC for a median 62 months. Intratumoral MVD was measured after microvessels were immunostained using anti-CD31 antibody. hormone receptors...
Abstract Coronavirus Disease 19 (COVID-19) is a respiratory disease caused by severe acute syndrome coronavirus 2 (SARS-CoV-2), which has grown to worldwide pandemic with substantial mortality. Immune mediated damage been proposed as pathogenic factor, but immune responses in lungs of COVID-19 patients remain poorly characterized. Here we show transcriptomic, histologic and cellular profiles post mortem ( n = 34 tissues from 16 patients) normal lung 9 6 patients). Two distinct...
Objective Operative link on gastritis assessment (OLGA) staging for ranks the risk gastric cancer (GC) in progressive stages (0–IV). This prospective study aimed at quantifying associated with each stage. Design A cohort of 1755 consecutive patients dyspepsia underwent initial (T-0) oesophagogastroduodenoscopy mapped biopsies, OLGA and Helicobacter pylori infection. Patients were followed 55 months (median); II III IV a second endoscopy/restaging (T-1), those 0 I clinically through in-depth...
Myoepithelial cells (MCs) constitute the basal cell layer of normal mammary epithelia, and their identification is particular diagnostic value because they are retained in most benign lesions while being lost malignancy. Several MC immunocytochemical markers currently available for purposes, with special reference to smooth muscle-related antigens. p63 a member p53 gene family, its germline mutations associated severe developmental defects both rodents humans. Different isoforms have been...
AIMS: To investigate the expression of two cell cycle related antigens (proliferating nuclear antigen (PCNA) and Ki67 antigen) in a series breast cancers; possible correlations between PCNA labelling indexes (PCNA-LI Ki67-LI) their associations with other biological clinicopathological variables. METHODS: Ninety six ductal 10 lobular carcinoma specimens were investigated. Samples fixed formalin Methacarnoy for localisation PCNA. was immunostained on frozen sections. The PCNA-LI Ki67-LI...
Abstract BACKGROUND Syndecan‐1 is a transmembrane heparan sulphate proteoglycan that involved in cell–cell adhesion, organization of cell–matrix and regulation growth factor signaling. METHODS Specimens from 254 consecutive breast carcinoma (BC) cases (110 N0, 144 N1/2) with long‐term follow‐up (median, 95 months) were immunostained for syndecan‐1, estrogen receptor (ER), progesterone (PgR), p53; 154 cases, c‐erbB‐2 status was known. mRNA protein expression also evaluated 20 tissue samples...
Lung metastases from colorectal carcinomas (CRC) can be resected with improved survival. The distinction between primary lung adenocarcinomas and CRC may sometimes difficult, especially on cytologic specimens or small bronchoscopic biopsies. Immunohistochemistry of help in this setting: available markers include TTF-1 SP-A, which are origin, whereas there no good intestinal besides cytokeratin 7 20 coexpression pattern, is not very specific. nuclear CDX-2 transcription factor, the product a...
Abstract Purpose: In breast cancer, the PIK3CA gene is frequently mutated at “hotspots” in exons 9 and 20, corresponding to helical kinase domains, respectively. We decided investigate association of mutations with pathologic features clinical outcome a large series patients cancer. Experimental Design: Frozen samples from 163 consecutive were analyzed for using PCR single-strand conformation polymorphism sequence analyses. Results: identified 46 missense mutations, 24 (53%) exon 9, 21 (47%)...
Histopathological subtyping of nonsmall cell lung cancer (NSCLC) is currently relevant in treatment decision because a differential activity specific therapeutic agents. Immunohistochemistry highlights differentiation lineages and, this study, it was applied to maximize the proportion accurately subtyped NSCLC not otherwise specified (NOS) on fine-needle aspiration cytology (FNAC) samples.Cell blocks from 103 FNAC samples with morphological diagnosis NSCLC-NOS were immunostained for...
Although Gastrointestinal stromal tumors (GISTs) affect about 0.0014% of the population, GISTs smaller than 1 cm (microGISTs) are detectable in 20% to 30% elderly individuals. This suggests that microGISTs likely represent premalignant precursors evolve only a minute fraction cases toward overt GISTs. We sought histopathologic and molecular explanations for infrequent clinical progression small To investigate mechanisms GIST identify subsets with differential malignant potential, we carried...
Extensive studies revealed that the human corpus callosum (CC) plays a crucial role in providing large-scale bi-hemispheric integration of sensory, motor and cognitive processing, especially within frontal lobe. However, literature lacks conclusive data regarding structural macroscopic connectivity CC. In this study, novel microdissection approach was adopted, to expose fibers CC from dorsum lateral cortex eight hemispheres one entire brain. Post-mortem results were then combined with...
Abstract Objectives We performed data collection concerning the coronavirus disease 2019 (COVID-19) pandemic-related delay in diagnosis of cancers to individuate proper corrective procedures. Methods A comparison was made among number first pathologic diagnoses malignancy from weeks 11 20 2018, 2019, and 2020 at seven anatomic pathology units serving secondary care hospitals northern-central Italy. Results Cancer fell by 44.9% compared with average recorded 2018 2019. Melanoma nonmelanoma...
Receptor status, proliferative activity, loss of differentiation, inactivation tumor suppressor genes, and overexpression oncogenes are related events that may affect the prognosis patients with breast cancer. Ninety-seven unselected carcinomas were immunostained for estrogen progesterone receptors, Ki-67 proliferation-associated antigen, p53 gene product (p53), c-erbB-2 protein. Immunohistochemical results clinical data compared. Altered expression (regarded as indirect indication...
Ki67 labeling index (Ki67 LI), the percentage immunoreactive cells, is a measure of tumor proliferation, with important clinical relevance in breast cancer, and it extremely to standardize its evaluation.To test efficacy computer assisted image analysis (CAIA) applied completely digitized slides assess feasibility routine practice compare results obtained using two different monoclonal antibodies.315 consecutive cancer routinely immunostained for Ki-67 (223 SP6 92 MM1 antibodies previously...
The increased cap-independent translation of anti-apoptotic proteins is involved in the development drug resistance lung cancer but signalling events regulating this are poorly understood. Fibroblast growth factor 2 (FGF-2) signalling-induced S6 kinase (S6K2) activation necessary, downstream mediator(s) coupling to translational response unknown. Here, we show that S6K2 binds and phosphorylates hnRNPA1 on novel Ser4/6 sites, increasing its association with BCL-XL XIAP mRNAs promote their...