A5083581067- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Parathyroid Disorders and Treatments
- Forensic Anthropology and Bioarchaeology Studies
- Health Systems, Economic Evaluations, Quality of Life
- Magnesium in Health and Disease
- Dialysis and Renal Disease Management
- Eosinophilic Esophagitis
- Advanced materials and composites
- Lysosomal Storage Disorders Research
- Nasal Surgery and Airway Studies
- Thyroid Cancer Diagnosis and Treatment
- dental development and anomalies
- Sinusitis and nasal conditions
- Eating Disorders and Behaviors
- Total Knee Arthroplasty Outcomes
- Patient Satisfaction in Healthcare
- Hemoglobinopathies and Related Disorders
- Clinical practice guidelines implementation
- Health, Environment, Cognitive Aging
- Orthopaedic implants and arthroplasty
- Global Health Care Issues
- Dental Education, Practice, Research
- Cleft Lip and Palate Research
Sanofi (Italy)
2016-2025
University of Chieti-Pescara
2015
Regione Toscana
2015
Agenzia Regionale di Sanità della Toscana
2015
Agenzia Sanitaria e Sociale Regionale
2009
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by recurrent eczematous lesions and intense pruritus. AD patients are known to face considerable burden, including physical emotional limitations. There still limited knowledge about daily implications in education occupation. We describe social stigmatization measuring bullying self-isolation students professional discrimination workers. Overall loss of productivity, either at school the workplace, was quantified as...
Background: Chronic rhinosinusitis with nasal polyps (CRSwNPs) is a chronic inflammatory disease associated frustrating symptoms, particularly obstruction and loss of smell. We conducted patient survey on the significant burden disease, specific focus conditions that affect health, sleep quality, absenteeism, presenteeism, including caregivers' perspectives. Methods: An online questionnaire was sent to 4230 randomly selected recipients, 200 matched inclusion criteria for self-reported...
Atopic dermatitis (AD) is a chronic, relapsing and remitting inflammatory skin disease characterized by intense itch. The burden includes physical limitations, psychosocial discomfort, reduced quality of life (HRQoL). This study presents the results parent-reported survey on impact AD Italian pre-adolescent children (6-11 years old), with specific focus bullying, self-isolation, absenteeism, presenteeism.An online questionnaire was sent to 3067 random recipients 160 matched inclusion...
<b><i>Objectives:</i></b> To conduct a cost-effectiveness analysis of sevelamer versus calcium carbonate in patients with non-dialysis-dependent CKD (NDD-CKD) from the Italian NHS perspective using patient-level data INDEPENDENT-CKD study. <b><i>Methods:</i></b> Patient-level on all-cause mortality, dialysis inception and phosphate binder dose were obtained for all 107 105 Hospitalization frequency collected post hoc via retrospective chart...
In multiple phase 3 trials, dupilumab improved signs, symptoms (including pruritus), and quality-of-life (QoL) in adults with moderate-to-severe atopic dermatitis (AD). Italy, received innovation status but is currently only reimbursed by the National Health Service for Eczema Area Severity Index (EASI) scores ≥24. This analysis assesses disease burden efficacy EASI above below this threshold.This post-hoc included 299 pooled from two, randomized, placebo-controlled, LIBERTY AD CAFÉ...
Background Eosinophilic esophagitis (EoE) is a chronic and progressive type 2 inflammatory disease affecting the esophagus. Its prevalence has increased in recent years due to awareness, evolving clinical guidelines, heightened sensitivity among healthcare professionals managing condition. The exact causes behind EoE’s development remain unknown, its presentation varies, often leading significant diagnostic delays depending on age at which symptoms manifest. Consequently, achieving long-term...
Background and research question: Label extension for treatments the relevant disease cross-coverage may produce an economic benefit. This paper assesses this benefit dupilumab in perspective of Italian National Health Service. Dupilumab was approved reimbursement severe atopic dermatitis (AD), refractory asthma chronic rhinosinusitis with nasal polyps (CRSwNP). The analysis focused on crowding-out effect alternative treatments.
 Methods: relied a simplified budget impact model. model...
Background: Lysosomal storage diseases (LSDs) are a heterogeneous group of rare chronic genetic conditions. The standard-of-care treatment for LSDs is hospital-based infusion enzyme replacement therapy (ERT), however, over time this can be stressful and inconvenient. Italian TuTor program, established in 2011 by Sanofi Genzyme, professional nursing service providing home-based ERT to patients with LSDs.Objectives: current questionnaire-based study was conducted investigate the level patient...
BACKGROUND: Radioiodine ablation is an adjuvant procedure used to treat patients with differentiated thyroid cancer. For be successful, must have elevated levels of stimulating hormone (TSH). This can achieved by withholding therapy (endogenous stimulation), or administration recombinant human (rhTSH; Thyrogen®; exogenous stimulation) in the euthyroid state.AIM: To compare estimated health benefits, cost and cost-effectiveness TSH stimulation without Thyrogen® Italian setting.METHODS: A...
ResultsResults of the analyses showed that CRC screening programme is cost-effective in Flanders with an ICER E1,277/QALY (95%CI: ÀE3,461 -E5,397) males and E5,397/QALY (95% CI: E260 -E25,847) females.Mortality reduction over a period 20 years was 21% 16%-24%) 15% 12%-18%) females.Sensitivity identified test-characteristics iFOBT to be most influencing parameters, but all cases remained cost-effective. ConclusionsThis health economic analysis has weighted advantages disadvantages organised...