A5063407748- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Diseases and Immunity
- Renal Transplantation Outcomes and Treatments
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Gallbladder and Bile Duct Disorders
- Alcohol Consumption and Health Effects
- Pediatric Hepatobiliary Diseases and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal cell carcinoma treatment
- Organ Donation and Transplantation
- Pancreatic and Hepatic Oncology Research
- Substance Abuse Treatment and Outcomes
- Cancer, Hypoxia, and Metabolism
- Neurological Complications and Syndromes
- Drug-Induced Hepatotoxicity and Protection
- Congenital Anomalies and Fetal Surgery
- Lymphoma Diagnosis and Treatment
- TGF-β signaling in diseases
- Polyomavirus and related diseases
- Viral-associated cancers and disorders
- Ultrasound and Hyperthermia Applications
Kansai Medical University
1998-2025
University Medical Center
2023-2025
The University of Tokyo
2006-2021
Kyoto University
2015-2019
Kyoto University Hospital
2017-2019
University of Tokyo Hospital
2011-2014
European Society for Organ Transplantation
2008-2010
Vall d'Hebron Hospital Universitari
2008
Universitat Autònoma de Barcelona
2008
Japanese Red Cross Medical Center
2008
BACKGROUND The authors compared the efficacy of percutaneous microwave coagulation therapy (PMCT) and ethanol injection (PEIT) in treatment patients with cirrhosis a solitary nodular hepatocellular carcinoma (HCC) ≤ 2 cm greatest dimension. METHODS Of 43 well-differentiated HCC, 23 were treated PMCT 20 PEIT. 47 moderately or poorly differentiated 25 22 In retrospective, nonrandomized study, prognoses 90 during 12–72 months preceding study analyzed according to histologic tumor grade. RESULTS...
Three tumor markers for hepatocellular carcinoma (HCC) are available in daily practice Japan: alpha-fetoprotein (AFP), des-gamma-carboxy prothrombin (DCP), and lens culinaris agglutinin-reactive fraction of (AFP-L3). To elucidate the predictability these on HCC recurrence after curative ablation, we enrolled 416 consecutive patients with naïve who had been treated by percutaneous ablation at our department from July 1997 to December 2002. Tumor marker levels were determined immediately...
BACKGROUND A small number of microwave electrode insertions and irradiations were used to obtain complete tumor necrosis in hepatocellular carcinomas (HCC) measuring > 2.0 cm but ≤ 3.0 greatest dimension. The efficacy combining transcatheter arterial chemoembolization (TACE) with subsequent percutaneous coagulation therapy (PMCT) was assessed this study. METHODS Eighteen patients cirrhosis HCCs dimension underwent TACE followed within 1–2 days by ultrasonographically guided PMCT. RESULTS On...
To investigate the influence of donor age on recipient outcome after living-donor partial liver transplantation (LDLT).Donor is a well-known prognostic factor in deceased transplantation; however, its role LDLT remains unclear.We retrospectively analyzed 315 consecutive cases primary adult-to-adult our center between April 2006 and March 2014. Recipients were divided into 5 groups according to age: D-20s (n = 60); D-30s 72); D-40s 57); D-50s 94); D-60s 32). The survival association with...
Nationwide surveys of acute liver failure (ALF) are conducted annually in Japan, and 20% patients with ALF undergo transplantation (LT). We extracted data for 212 who underwent LT from the nationwide survey database Intractable Liver Diseases Study Group Japan. After exclusion 3 deceased donor LT, 209 recipients living (LDLT) were analyzed. placed into subgroups according to time onset disease occurrence encephalopathy: presented encephalopathy within 10 days disease's classified as having...
Abstract Aim The diagnosis of drug‐induced liver injury (DILI) is challenging. We modified the revised electronic version Roussel Uclaf Causality Assessment Method (RUCAM) for DILI (RECAM), scoring system developed in US and Spanish cohorts 2022, RECAM‐J 2023 to align with clinical practice Japan. In current study, we introduce verify its performance context Japanese patients DILI. Methods After translation RECAM into Japanese, modifications were made develop without any alteration scores....
Objective: Percutaneous microwave coagulation therapy (PMCT) was performed for metachronous small solitary liver tumors measuring ≤3.0 cm in diameter that had metastasized from colorectal cancer. PMCT used local control of the lesions, and efficacy this treatment assessed. Methods: In 15 patients, a electrode (specially designed purpose, 25 long 2.0 mm thick) inserted percutaneously into tumor area under ultrasonic guidance. Microwaves at 80 watts were to irradiate surrounding area. Results:...
Abstract Background and Aim: Impaired health‐related quality of life has been reported in patients with cirrhosis chronic hepatitis. However, only limited data are available concerning the influence hepatocellular carcinoma. Methods: Health‐related was assessed 97 carcinoma who had treated successfully percutaneous ablation therapy, liver disease without matched for age sex, using Japanese version Short‐Form 36. Raw scores were transformed norm‐based scoring. The relations objective...
Primary sclerosing cholangitis (PSC) is a progressive cholestatic liver disease, with transplantation being the sole life-saving treatment for end-stage PSC-related disease. However, recurrence of PSC after common complication, risk factors controversial.We conducted retrospective chart review 45 patients who had undergone at our institute. The and graft failure were analyzed.The survival rates 55.4% 5 years 32.8% 10 PSC. was diagnosed in 16 (40%) 40 patients, median 30 months (range, 9-70...
Organ transplant recipients have an increased incidence of malignancy. Race differences in a variety malignancies are observed among the general population, but de novo after adult-to-adult living-donor liver transplantation (LDLT) not been compared with those from Japanese population-based study.The subjects were 360 adult LDLT who survived more than 1 year transplantation. An annual medical checkup and screening examinations performed as follows: abdominal computed tomography or magnetic...
Protein induced vitamin K absence or antagonist II (PIVKA-II) and alpha-fetoprotein (AFP) have been considered useful serum markers of hepatocellular carcinoma (HCC). In this study, we examined the clinicopathologic significance these tumour in patients with HCCs by measuring their levels performing immunohistochemistry. We studied 349 Japanese HCCs. Their PIVKA-II AFP were determined enzyme immunoassay before treatment. correlations between size, presence satellite nodules, histologic HCC...
Transforming growth factor β (TGF-β) initiates signaling through heteromeric complexes of transmembrane type I and II serine/threonine kinase receptors. Activated TGF-β receptor phosphorylates receptor-regulated Smads (2 3). Antagonistic Smad 7 forms stable association with the activated receptor, blocking phosphorylation Smads. On other hand, elevated serum concentration along resistance to its growth-inhibitory effect is commonly observed in human hepatocellular carcinoma (HCC) patients....
The selection of living donor liver transplantation (LDLT) recipients in regions where deceased (DDLT) is rarely performed might be different from that other centers at which LDLT an alternative option to DDLT. Records adult (age ≥ 18 yr) patients referred our center were reviewed analyze the process candidates. Among 533 candidates, 165 (31%) rejected due recipient issues. Advanced hepatocellular carcinoma (HCC) was most common reason for rejection (n = 55). remaining recipients, 120 (22%)...