A5041576626- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- TGF-β signaling in diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease and Transplantation
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Liver physiology and pathology
- Renal cell carcinoma treatment
- Hepatitis C virus research
- Drug-Induced Hepatotoxicity and Protection
- Genetic factors in colorectal cancer
- Liver Diseases and Immunity
- Hepatitis B Virus Studies
- Ovarian cancer diagnosis and treatment
- Biliary and Gastrointestinal Fistulas
- Endoplasmic Reticulum Stress and Disease
- Gastric Cancer Management and Outcomes
- Ultrasound and Hyperthermia Applications
- Alcohol Consumption and Health Effects
- Medical Image Segmentation Techniques
- Pharmacological Effects of Natural Compounds
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Nanoplatforms for cancer theranostics
Kansai Medical University
2014-2023
Yamaguchi University
2023
University Medical Center
2018-2023
Center for HIV and Hepatogastroenterology
2007-2009
Scott & White Memorial Hospital
2008
Josai University
2008
Third Way
1998-2007
Nihon University
2005
University of Miami
2001
Institute of Applied Biochemistry
1996
Background. The authors have used percutaneous microwave coagulation therapy (PMCT) as a new local treatment for single unresectable hepatocellular carcinoma (HCC) measuring 2 cm or less in greatest dimension (small HCC). PMCT was to attempt cure of the disease. In this study, efficacy assessed. Methods. performed on 18 patients with small HCC. A electrode (custom-made, 30-cm long by 1.6-mm thick) inserted percutaneously into tumor area under ultrasonic guidance. Microwaves at 60 W 120...
The Japan Integrated Staging score (JIS score), which combines the Child–Turcotte–Pugh classification and tumor–node–metastasis staging, has been proposed as a better prognostic staging system for hepatocellular carcinoma (HCC) than Cancer of Liver Italian Program (CLIP) scoring system. In this study, validation was performed among larger patient population. A total 4,525 consecutive patients with HCC who had diagnosed at five institutions were included. Stratification ability, predictive...
Abstract Many patients with chronic hepatitis caused by C virus (HCV) infection develop liver fibrosis high risk for hepatocellular carcinoma (HCC), but the mechanism underling this process is unclear. Conversely, transforming growth factor beta (TGF-β) activates not only TGF-β type I receptor (TβRI) also c-Jun N-terminal kinase (JNK), which convert mediator Smad3 into two distinctive phosphoisoforms: C-terminally phosphorylated (pSmad3C) and linker-phosphorylated (pSmad3L). Whereas...
Hepatic stellate cells (HSCs) spontaneously transdifferentiate into myofibroblast (MFB)–phenotype on plastic dishes. This response recapitulates the features of activation in vivo. Transforming growth factor β (TGF–β) plays a prominent role stimulating liver fibrogenesis by MFBs. In quiescent HSCs, TGF–β signaling involves type I receptor (TβRI)–mediated phosphorylation serine residues within conserved SSXS motif at C–terminus Smad2 and Smad3. The middle linker regions Smad3 also are...
DNA extracted from squamous cell carcinomas patients with the chronic wart disease syndrome, epidermodysplasia verruciformis, was analyzed for presence of human papillomavirus (HPV)-specific sequences by Southern blot hybridization analysis. Employing an HPV probe obtained molecular cloning viral purified benign warts these patients, we have unequivocally identified HPV-specific nucleotide in patients. Restriction endonuclease mapping indicated that present same type (type 5) as found tumors...
Hepatitis B virus X (HBx) protein is suspected to participate in oncogenesis during chronic hepatitis progression. Transforming growth factor beta (TGF-beta) signaling involves both tumor suppression and oncogenesis. TGF-beta activates type I receptor (TbetaRI) c-Jun N-terminal kinase (JNK), which differentially phosphorylate the mediator Smad3 become C-terminally phosphorylated (pSmad3C) linker-phosphorylated (pSmad3L). Reversible shifting of Smad3-mediated between HBx-expressing...
Hepatocellular carcinoma (HCC) is characterized by frequent recurrence, even after curative treatment. Vitamin K2, which has been reported to reduce HCC development, may be effective in preventing recurrence. Patients who underwent ablation or resection of were randomly assigned receive placebo, 45 mg/day, 90 mg/day vitamin K2 double-blind fashion. recurrence was surveyed every 12 weeks with dynamic computed tomography/magnetic resonance imaging, HCC-specific tumor markers monitored 4 weeks....
BACKGROUND The authors compared the efficacy of percutaneous microwave coagulation therapy (PMCT) and ethanol injection (PEIT) in treatment patients with cirrhosis a solitary nodular hepatocellular carcinoma (HCC) ≤ 2 cm greatest dimension. METHODS Of 43 well-differentiated HCC, 23 were treated PMCT 20 PEIT. 47 moderately or poorly differentiated 25 22 In retrospective, nonrandomized study, prognoses 90 during 12–72 months preceding study analyzed according to histologic tumor grade. RESULTS...
BACKGROUND A small number of microwave electrode insertions and irradiations were used to obtain complete tumor necrosis in hepatocellular carcinomas (HCC) measuring > 2.0 cm but ≤ 3.0 greatest dimension. The efficacy combining transcatheter arterial chemoembolization (TACE) with subsequent percutaneous coagulation therapy (PMCT) was assessed this study. METHODS Eighteen patients cirrhosis HCCs dimension underwent TACE followed within 1–2 days by ultrasonographically guided PMCT. RESULTS On...
The Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein (AFP-L3) has been reported to be a highly useful marker for hepatocellular carcinoma (HCC) compared with conventional serum AFP concentration, which allows earlier detection HCC using other imaging modalities and predicting prognosis after therapy. A collaborative prospective study involving nine Japanese hospitals was conducted analyze the relationships between tumor characteristics patient percentage AFP-L3/AFP total at...
Abstract Cancer cells often gain advantage by reducing the tumor-suppressive activity of transforming growth factor-β (TGF-β) together with stimulation its oncogenic as in Ras-transformed cells; however, molecular mechanisms remain largely unknown. TGF-β activates both type I receptor (TβRI) and c-Jun NH2-terminal kinase (JNK), which phosphorylate Smad2 Smad3 at COOH-terminal (pSmad2/3C) linker regions (pSmad2/3L). Here, we report that Ras transformation suppresses TβRI-mediated pSmad3C...
Abstract Transforming growth factor (TGF)-β initially inhibits of mature epithelial cells. Later, however, autocrine TGF-β signaling acts in concert with the Ras pathway to induce a proliferative and invasive phenotype. activates not only type I receptor (TβRI) but also Ras-associated kinases, which differentially phosphorylate mediators Smad2 Smad3 create distinct phosphorylated forms: COOH-terminally Smad2/3 (pSmad2C pSmad3C) both linker (pSmad2L/C pSmad3L/C). In this study, we...
To clarify information on and frequency of complications as well mortality rate after radiofrequency ablation (RFA) for hepatocellular carcinoma.The results a questionnaire obtained mainly from members the Osaka Liver Cancer Study Group at 43 departments 38 facilities were analyzed in order to current status RFA, death occurring RFA.Between January 1999 May 2002, total 3,891 RFA therapies performed percutaneously 2,542 patients, laparoscopically 23, operatively 49 (2,614 patients total)....
The effects of cycloprodigiosin hydrochloride (cPrG-HCl), a new H + /Cl − symporter, were examined in liver cancer cell lines vitro and vivo . In the MTT assay, cPrG-HCl inhibited growth 6 (Huh-7, HCC-M, HCC-T, dRLh-84, H-35, hepatocellular carcinoma; HepG2, hepatoblastoma) dose- time-dependent manner. 50% inhibitory concentrations (IC 50 ) at 72 hours' treatment for 276 to 592 nmol/L, while that isolated normal rat hepatocyte was 8.4 μmol/L. Huh-7 cells induced apoptosis as confirmed by...
The clinical profile of primary biliary cirrhosis in Japan was clarified on the basis data 1066 patients attending 212 hospitals and institutions this country. Six hundred twelve (57.4%) were asymptomatic. majority middle‐aged women. Pruritus most frequent initial symptom symptomatic cirrhosis. Antimitochondrial antibodies positive 877 (82.5%). Sjögren's syndrome common associated autoimmune disease. Liver biopsy performed 753 at time diagnosis, histological staging by Scheuer's...
Conversion of normal epithelial cells to tumors is associated with a shift in transforming growth factor-beta (TGF-beta) function: reduction tumor suppressor activity and increase oncogenic activity. However, specific mechanisms this functional alteration during human colorectal carcinogenesis remain be elucidated. TGF-beta signaling involves Smad2/3 phosphorylated at linker regions (pSmad2/3L) COOH-terminal (pSmad2/3C). Using antibodies each phosphorylation site, we herein showed that Smad2...
Cisplatin is commonly used as a chemotherapeutic agent for hepatocellular carcinoma (HCC). However, it cannot satisfactorily improve the survival rate patients with advanced HCC due to intrinsic or acquired drug resistance caused by multidrug resistance-associated proteins (MRPs). To clarify whether not glycyrrhizin and lamivudine have modulator effects on treated cisplatin, we established cisplatin-resistant Huh7 cell line analyzed mRNA expression of MRPs in resistant cells. The cells...
Patients with liver cirrhosis often exhibit zinc deficiency. Although is involved in many bioactivities, aspects of clinical implications deficiency remain unclear. We aimed to reveal the prevalence and by assessing associations parameters such as symptoms laboratory data.In 235 patients enrolled at multiple medical institutions 2009, we assessed how blood levels were associated their symptoms, characteristics, function test results.Blood most strongly correlated albumin among study (r =...
We report one patient who showed rapid progression of hepatocellular carcinoma (HCC) after undergoing transcatheter arterial chemoembolization (TACE) and percutaneous radiofrequency ablation (PRFA) for a small HCC measuring 2.5 cm in diameter. Enhanced magnetic resonance imaging (MRI) following treatment complete tumour necrosis did not reveal the presence around treated area. Furthermore, serum alpha-fetoprotein (AFP) level decreased at completion therapy. However, advanced very short time....