A5041284607- Liver Disease Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
- Liver Disease and Transplantation
- Lymphoma Diagnosis and Treatment
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Gallbladder and Bile Duct Disorders
- Liver physiology and pathology
- Tryptophan and brain disorders
- Hepatitis B Virus Studies
- Tea Polyphenols and Effects
- Pediatric Hepatobiliary Diseases and Treatments
- Gastric Cancer Management and Outcomes
- Estrogen and related hormone effects
- Antioxidant Activity and Oxidative Stress
- Acute Myeloid Leukemia Research
- Pancreatic and Hepatic Oncology Research
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- Chronic Lymphocytic Leukemia Research
- Drug-Induced Hepatotoxicity and Protection
- Hepatitis C virus research
- Organ Transplantation Techniques and Outcomes
- Gastrointestinal disorders and treatments
Matsunami General Hospital
2024-2025
Gifu University
2011-2024
The Japanese Society of Gastroenterological Surgery
2016
Gifu University Hospital
2006-2015
University Gastroenterology
2013
Icahn School of Medicine at Mount Sinai
2013
Hadassah Medical Center
2013
Kanazawa Medical University
2008-2011
Ajinomoto (Japan)
2011
AntiCancer (United States)
2011
Objective— Atherosclerosis is considered to be a chronic inflammatory disease and many cytokines participate in the development of atherosclerosis. We focused on role interleukin-1β (IL-1β), one proinflammatory secreted by monocytes/macrophages, progression Methods Results— generated mice lacking both apoE IL-1β. The sizes atherosclerotic lesions at aortic sinus apoE−/−/IL-1β−/−mice 12 24 weeks age showed significant decrease approximately 30% compared with apoE−/−/IL-1β +/+ mice, percentage...
Abstract Purpose: (−)-Epigallocatechin gallate (EGCG) inhibits activation of the epidermal growth factor receptor (EGFR) and human receptor-2 (HER2) multiple downstream signaling pathways in cancer cell lines. In this study we compared cellular molecular effects EGCG with a well-standardized decaffeinated green tea catechin mixture Polyphenon E (Poly E) on colon Experimental Design Results: Both Poly preferentially inhibited Caco2, HCT116, HT29, SW480, SW837 cells when FHC normal fetal line....
Endoscopic biliary stenting is a well-established palliative treatment for unresectable malignant strictures, which plastic tube stents (PSs) and self-expandable metallic (SEMSs) are most commonly used. The efficacy of these has been extensively described in distal but not hilar strictures. present study aimed to compare the PSs SEMSs strictures.From June 2004 November 2008, 60 patients were enrolled prospectively randomized into PS or SEMS group.The 6-month patency rate was significantly...
Abstract Background: Experimental studies indicate the chemopreventive properties of green tea extract (GTE) on colorectal cancer. Epidemiologically, consumption >10 cups daily reduced cancer risk in Japanese. Because adenomas are precursors to most sporadic cancers, we conducted a randomized trial determine preventive effect GTE supplements metachronous by raising target population from an average 6 (1.5 g GTE) ≥10 equivalent (2.5 supplemental tablets. Methods: We recruited 136...
Sarcopenia impairs the outcome of patients with liver cirrhosis independently function reserves. The aim this study was to investigate whether rate skeletal muscle wasting predicts mortality in cirrhotic patients.This retrospective evaluated 149 who visited our hospital between March 2004 and September 2012. cross-sectional area at level third lumbar vertebra measured by computed tomography, from which index obtained for diagnosis sarcopenia. relative change per year (ΔSMA/y) calculated each...
We conducted a multicenter, retrospective study to determine the anatomical distribution and prognostic factors of gastrointestinal (GI) follicular lymphoma (FL). This included 125 patients with stage I II(1) GI-FL. Of patients, small intestine was examined in 70 double-balloon endoscopy and/or capsule endoscopy. The most frequently involved GI-FL site duodenal second portion (DSP) (81%), followed by jejunum (40%); 85% involvement DSP also had jejunal or ileal lesions. absence abdominal...
Minimal hepatic encephalopathy (MHE) and sarcopenia impair the health-related quality of life prognosis patients with liver cirrhosis; however, relationship between MHE remains unclear. The aim this study was to investigate their identify predictors in cirrhotic patients.This retrospective evaluated 120 who were tested for sarcopenia. diagnosed by using computer-aided neuropsychiatric test. Sarcopenia based on assessment criteria recommended Japan Society Hepatology. Muscle mass muscle...
Significance Hepatocellular carcinoma (HCC) is a highly lethal cancer, partly because of its high rate recurrence, which caused by the presence liver cancer stem cells (CSCs). Here, using selective chemopreventive agent, acyclic retinoid (ACR), as bioprobe, we identified MYCN , mostly recognized an oncogene in neuroblastoma, therapeutic target ACR for HCC through deletion + CSCs. We also demonstrated that expression served prognostic biomarker and positively correlated with recurrence de...
Abstract Human hepatocytes usually are resistant to TNF-α cytotoxicity. In mouse or rat hepatocytes, repression of NF-κB activation is sufficient induce TNF-α-mediated apoptosis. However, in both Huh-7 human hepatoma cells and Hc normal when infected with an adenovirus expressing a mutated form IκBα (Ad5IκB), which almost completely blocks activation, >80% the survived 24 h after stimulation. Here, we report that activates other antiapoptotic factors, such as sphingosine kinase...