A5065822023- Retinoids in leukemia and cellular processes
- Tea Polyphenols and Effects
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Phytochemicals and Antioxidant Activities
- Metabolism, Diabetes, and Cancer
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Estrogen and related hormone effects
- Cancer, Stress, Anesthesia, and Immune Response
- Salivary Gland Tumors Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Nutrition and Health in Aging
- Inflammasome and immune disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Mechanisms and Therapy
- Cancer-related Molecular Pathways
- Oral and Maxillofacial Pathology
- Peroxisome Proliferator-Activated Receptors
- Tannin, Tannase and Anticancer Activities
- Drug Transport and Resistance Mechanisms
- Gastrointestinal disorders and treatments
- Muscle Physiology and Disorders
- Neuroendocrine Tumor Research Advances
- Bone and Dental Protein Studies
Gifu University
2016-2025
Gifu University Hospital
2019-2024
Kanazawa Medical University
2008-2011
Nagasaki University
2006
Kyushu University
1988-2002
Municipal Tsuruga Hospital
1988
Keio University
1967
This study aimed to investigate the usefulness of psoas muscle index (PMI) as an independent predictor survival after systemic targeted therapy initiation in patients with hepatocellular carcinoma (HCC). In total, 214 HCC who underwent at Gifu University Hospital were enrolled. The correlation between PMI and skeletal (SMI) was assessed using Pearson's coefficient (PCC). Cox proportional hazards model employed determine whether PMI, along α-fetoprotein (AFP) level ALBI score, influenced...
Abstract Obesity and diabetes mellitus are risk factors for colon cancer. The activation of the insulin-like growth factor (IGF)/IGF-IR axis plays a critical role in this carcinogenesis. (−)-Epigallocatechin gallate (EGCG), major constituent green tea, seems to have both antiobesity antidiabetic effects. This study examined effects EGCG on development azoxymethane-induced colonic premalignant lesions C57BL/KsJ-db/db (db/db) mice, which obese develop mellitus. Male db/db mice were given four...
The receptor tyrosine kinase vascular endothelial growth factor (VEGF) (VEGFR) plays an important role in tumor angiogenesis of hepatocellular carcinoma (HCC). (-)-Epigallocatechin gallate (EGCG), the major biologically active component green tea, inhibits a variety human cancer cells by inhibiting activation several types kinases. In this study, we examined effects EGCG on activity VEGF-VEGFR axis HCC cells. levels total and phosphorylated (i.e. activated) form VEGFR-2 protein (p-VEGFR-2)...
Abstract Obesity and related metabolic abnormalities, including insulin resistance a state of chronic inflammation, increase the risk hepatocellular carcinoma. Abnormal activation insulin-like growth factor (IGF)/ IGF-1 receptor (IGF-1R) axis is also involved in obesity-related liver tumorigenesis. In present study, we examined effects (−)-epigallocatechin gallate (EGCG), major biologically active component green tea, on development diethylnitrosamine (DEN)-induced tumorigenesis...
Obesity and related metabolic abnormalities, including insulin resistance, are risk factors for hepatocellular carcinoma in non-alcoholic steatohepatitis as well chronic viral hepatitis. Branched-chain amino acids (BCAA), which improve inhibited obesity-related colon carcinogenesis a rodent model, also reduced the incidence of obese patients with liver cirrhosis. In present study, we determined effects BCAA on development diethylnitrosamine (DEN)-induced tumorigenesis C57BL/KsJ-db/db (db/db)...
Sodium glucose cotransporter 2 inhibitors are expected to ameliorate the abnormalities associated with metabolic syndrome including non-alcoholic fatty liver disease. In this study, we investigated effects of sodium inhibitor tofogliflozin on development disease-related tumorigenesis in C57BL/KsJ-+Lepr db /+Lepr obese and diabetic mice. The direct human cancer cell proliferation were also evaluated. Mice administered diethylnitrosamine-containing water for weeks treated throughout...
Non-alcoholic fatty liver disease (NAFLD), which is strongly associated with metabolic syndrome, increasingly a major cause of hepatic disorder. Dipeptidyl peptidase (DPP)-4 inhibitors, anti-diabetic agents, are expected to be effective for the treatment NAFLD. In present study, we established novel NAFLD model mouse using monosodium glutamate (MSG) and high-fat diet (HFD) investigated effects DPP-4 inhibitor, teneligliptin, on progression Male MSG/HFD-treated mice were divided into two...
The process of skin wound healing involves the following three steps: inflammation, tissue formation and remodelling. These optimal steps are required for development normal healing. Recent reports demonstrated that inflammasomes involved in innate immune response. In present study, we examined whether activation affects repair. repair model was established using wild-type (WT), NACHT, LRR PYD domains-containing protein 3 (NALP3) knockout (KO) ASC-KO mice. wounds were observed every other...
Obesity and related metabolic abnormalities are risk factors for colorectal cancer. A state of chronic inflammation adipocytokine imbalance may play a role in carcinogenesis. Statins, which commonly used the treatment hyperlipidemia, known to possess anti-inflammatory effects. Statins also exert chemopreventive properties against various cancers. The present study examined effects pitavastatin, recently developed lipophilic statin, on development azoxymethane (AOM)-initiated colonic...
Obesity-related metabolic abnormalities include a state of chronic inflammation and adipocytokine imbalance, which increase the risk colon cancer. Curcumin, component turmeric, exerts both cancer preventive antiinflammatory properties. Curcumin is also expected to have ability reverse obesity-related derangements. The present study examined effects curcumin on development azoxymethane (AOM)-induced colonic premalignant lesions in C57BL/KsJ-db/db (db/db) obese mice. Feeding with diet...
Abstract Obesity and the related metabolic abnormalities are associated with increased risk of hepatocellular carcinoma (HCC). Malfunctioning retinoid X receptor (RXR) α due to phosphorylation by Ras/MAPK also plays a critical role in liver carcinogenesis. In present study, we examined effects acyclic (ACR), which targets RXRα, on development diethylnitrosamine (DEN)-induced tumorigenesis C57BLKS/J- +Leprdb/+Leprdb (db/db) obese mice. Male db/db mice were given tap water containing 40 ppm...
Cholangiocarcinoma-associated mortality has been increasing over the past decade. The sodium-glucose cotransporter 2 inhibitor, canagliflozin, demonstrated anti-tumor effects against several types of cancers; however, studies examining its potential impact on cholangiocarcinoma are lacking. This study investigated canagliflozin and nicotinamide adenine dinucleotide (NAD)+ salvage pathway activation sirtuin 1 tumor growth. We evaluated cell proliferation gene expression in lines analyzed...
Obesity and related metabolic abnormalities, including inflammation lipid accumulation in the liver, play a role liver carcinogenesis. Adipocytokine imbalances, such as decreased serum adiponectin levels, are also involved obesity-related tumorigenesis. In present study, we examined effects of pitavastatin - drug used for treatment hyperlipidemia on development diethylnitrosamine (DEN)-induced preneoplastic lesions C57BL/KsJ-db/db (db/db) obese mice. Male db/db mice were administered tap...
The escape of preneoplastic cells from the immune system, which is caused by tolerance, occurs during development several types tumors. Indoleamine 2,3-dioxygenase (IDO) plays a critical role in induction tolerance. In present study we investigated effects 1-methyltryptophan (1-MT), an IDO inhibitor, and (-)-epigallocatechin gallate (EGCG), major catechin green tea, on azoxymethane (AOM)-induced colonic lesions focusing inhibition IDO. To induce premalignant lesions, male F344 rats were...
FXR is a member of the nuclear receptor superfamily and bile acids are endogenous ligands FXR. activation has recently been reported to inhibit intestinal inflammation tumour development. This study aimed investigate whether novel agonist nelumal A, active compound plant Ligularia nelumbifolia, can prevent colitis colorectal carcinogenesis. In mouse model, dextran sodium sulfate-induced colonic mucosal ulcer grade in colon significantly reduced mice fed diets containing A. an...
It has previously been shown that many osteoclast precursors are included in the granulation tissue within pseudocapsule obtained at revision arthroplasty from hips with osteolysis. In vitro culture of only cells isolated to generate mature osteoclasts.To investigate presence or otherwise supporting cells, similar stromal which differentiate osteoclasts tissue.Cells were cultured alone, and after four weeks fibroblast-like (granulation fibroblasts) remained. Rat non-adherent bone marrow...