A5000992341- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal disorders and treatments
- Liver Disease Diagnosis and Treatment
- Biliary and Gastrointestinal Fistulas
- Esophageal and GI Pathology
- Neuroendocrine Tumor Research Advances
- Acute Myeloid Leukemia Research
- Body Composition Measurement Techniques
- Central Venous Catheters and Hemodialysis
- Chronic Lymphocytic Leukemia Research
- Gastrointestinal Tumor Research and Treatment
- Autoimmune and Inflammatory Disorders
- Systemic Sclerosis and Related Diseases
- Retinoids in leukemia and cellular processes
- Lymphoma Diagnosis and Treatment
- Kawasaki Disease and Coronary Complications
- Body Contouring and Surgery
- Vascular Procedures and Complications
- Abdominal Surgery and Complications
- Enhanced Recovery After Surgery
- Engineering Applied Research
Gifu Prefectural General Medical Center
2019-2025
Gifu Prefecture General Education Center
2023-2024
RELX Group (Netherlands)
2023-2024
Gifu University
2015-2021
Gifu University Hospital
2017-2021
Nippon Steel (Japan)
1986
Sodium glucose cotransporter 2 inhibitors are expected to ameliorate the abnormalities associated with metabolic syndrome including non-alcoholic fatty liver disease. In this study, we investigated effects of sodium inhibitor tofogliflozin on development disease-related tumorigenesis in C57BL/KsJ-+Lepr db /+Lepr obese and diabetic mice. The direct human cancer cell proliferation were also evaluated. Mice administered diethylnitrosamine-containing water for weeks treated throughout...
Endoscopic transpapillary gallbladder drainage (ETGBD), including endoscopic nasogallbladder (ENGBD) and stenting (EGBS), has been reported to be an effective treatment for acute cholecystitis. However, ETGBD is considered more difficult than percutaneous transhepatic (PTGBD), few studies have evaluated the factors that affect technical success of procedure. We investigated predicting its from among patient characteristics image findings before treatment.Three hundred twenty three patients...
Objectives No comprehensive study has examined short‐ and long‐term adverse outcomes of endoscopic ultrasound (EUS)‐guided treatment pancreatic fluid collections (PFCs) including walled‐off necrosis (WON) pseudocysts. Methods In a multi‐institutional cohort 357 patients receiving EUS‐guided PFCs (228 with WON 129 pseudocysts), we PFC type‐specific risk factors for procedure‐related events (AEs), clinical failure, recurrence. Odds ratios (ORs) hazard (HRs) 95% confidence intervals (CIs) were...
Abstract Background Mapping biopsy (MB) can evaluate superficial ductal spread (SDS) through the histopathological diagnosis of cholangiocarcinoma, enabling selection an appropriate surgical procedure. This retrospective study evaluated efficacy MB using a novel sheath system in distal cholangiocarcinoma (dCCA) cases. Methods A total 199 cases underwent preoperative diagnosis. Among them, 40, 21, and 26 direct, sheath, peroral cholangioscopy (POCS) MB, respectively, for dCCA. Each group was...
Unresectable malignant bile duct stricture (often caused by unresectable pancreatic cancer and cholangiocarcinoma) can be drained via insertion of self-expandable metal stents (SEMS) during endoscopic retrograde cholangiopancreatography (ERCP). Because recurrent biliary obstruction (RBO) complications following stent delay chemotherapy other treatments, a longer time to RBO (TRBO) is desirable. Although TRBO has been reported among patients who undergo with larger diameter SEMS, smaller...
FOLFIRINOX (FX) has been reported as an effective treatment for unresectable advanced pancreatic cancer. However, FX is associated with a high incidence of adverse events (AEs). A previous phase II study in Japan showed incidences hematological AEs, including febrile neutropenia (22.2%). modified regimen (mFX) may decrease the rates AEs and be more than by improving compliance.To assess safety efficacy first-line mFX cancer.This was multicenter prospective chemotherapy-naïve Japanese...
Abstract Background With the increasing popularity of endoscopic ultrasound (EUS)-guided transmural interventions, walled-off necrosis (WON) pancreas is increasingly managed via non-surgical interventions. However, there has been an ongoing debate over appropriate treatment strategy following initial EUS-guided drainage. Direct necrosectomy (DEN) removes intracavity necrotic tissue, potentially facilitating early resolution WON, but may associate with a high rate adverse events. Given safety...
FXR is a member of the nuclear receptor superfamily and bile acids are endogenous ligands FXR. activation has recently been reported to inhibit intestinal inflammation tumour development. This study aimed investigate whether novel agonist nelumal A, active compound plant Ligularia nelumbifolia, can prevent colitis colorectal carcinogenesis. In mouse model, dextran sodium sulfate-induced colonic mucosal ulcer grade in colon significantly reduced mice fed diets containing A. an...
Endoscopic transpapillary gallbladder drainage (EGBD) has been reported as an effective treatment option for acute cholecystitis in high-risk surgical patients. However, the long-term outcomes such cholecystitis' recurrence rate after placement of EGB stenting (EGBS) have not well studied yet.The aim present study was to compare outcome EGBS and removal percutaneous transhepatic (PTGBD) or endoscopic nasogallbladder (ENGBD) patients clarify usefulness EGBS.We retrospectively 180 with between...
The placement of plastic stents (PS), including intraductal PS (IS), is useful in patients with unresectable malignant hilar biliary obstruction (UMHBO) because patency and ease endoscopic reintervention (ERI). However, the optimal stent replacement method for remains unclear.
Background: Extracorporeal shock wave lithotripsy (ESWL) is a common treatment for pancreatic stones in chronic pancreatitis. In contrast, peroral pancreatoscopy-guided (POPS-L) remains underexplored, with limited comparative studies to ESWL. This study compared the outcomes of disposable POPS-L tools and ESWL stones. Methods: A retrospective analysis was conducted on 66 patients who had undergone stone at three institutions between 2006 2022. The were compared. Results: included 19 47 ESWL,...
Abstract Background Although intraductal plastic stent (IS) placement is an effective treatment for unresectable malignant hilar biliary obstruction (UMHBO), the effectiveness of unilateral and bilateral IS drainage remains controversial. This retrospective study investigated UMHBO using propensity score matching method. Methods Patients who underwent transpapillary endoscopic stenting were analyzed technical clinical success, adverse events, time to recurrent (TRBO). Results A total 321...
Abstract Background One‐stage endoscopic management, where papillary interventions and stone removal are simultaneously performed, has been reported to be an effective treatment for acute cholangitis caused by common bile duct stones (CBDS). However, there have few reports comparing it with two‐stage is no established strategy the indication of one‐stage management. The aim present study was compare short‐ long‐term outcomes between one‐ management CBDS. Methods We retrospectively studied...
Objectives The appropriate holistic management is mandatory for successful endoscopic ultrasound (EUS)‐guided treatment of pancreatic fluid collections (PFCs). However, comorbidity status has not been fully examined in relation to clinical outcomes this treatment. Methods Using a multi‐institutional cohort 406 patients receiving EUS‐guided PFCs 2010–2020, we the associations Charlson Comorbidity Index (CCI) with in‐hospital mortality and other outcomes. Multivariable logistic regression...
Endoscopic ultrasound (EUS)-guided transmural drainage with on-demand endoscopic necrosectomy (EN) is increasingly utilized to manage walled-off necrosis (WON). It has not been fully elucidated how EN and its timing are correlated treatment outcomes compared the drainage-based approach.
Background and Aim Endoscopic sphincterotomy ( ES ) is a standard procedure for the treatment of common bile duct stones CBDS ). papillary large balloon dilation EPLBD emerging as an effective method to treat difficult , providing several advantages over without increasing early adverse events AE However, late have not yet been well studied. The aim present study was compare after versus using propensity score‐based cohort analysis. Methods Propensity score matching introduced reduce...
A pathological diagnosis of pancreatic cancer should be performed as much possible to determine the appropriate treatment strategy, but priorities and algorithms for diagnostic methods have not yet been established. In recent years, endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) has become primary method collecting tissues from disease, effect EUS-FNA on surgical results prognosis clarified.To evaluate ability its preoperative diagnosis, outcome, cancer.Between January 2005...