A5013162521- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Gastrointestinal disorders and treatments
- Neuroendocrine Tumor Research Advances
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Screening and Detection
- Cancer Genomics and Diagnostics
- Helicobacter pylori-related gastroenterology studies
- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- IgG4-Related and Inflammatory Diseases
- Metastasis and carcinoma case studies
- Tracheal and airway disorders
- Pancreatitis Pathology and Treatment
- Lung Cancer Diagnosis and Treatment
- Gastroesophageal reflux and treatments
- Diverticular Disease and Complications
- Electrolyte and hormonal disorders
- Tuberculosis Research and Epidemiology
- Mathematical Biology Tumor Growth
- Vascular Malformations and Hemangiomas
- Intestinal Malrotation and Obstruction Disorders
- Infectious Diseases and Tuberculosis
Mie University Hospital
2018-2025
Mie University
1990-2024
Weatherford College
2020
Aichi Cancer Center
2009-2010
Abstract Intestinal fibrosis is a serious complication in inflammatory bowel disease (IBD). Despite the remarkable success of recent anti-inflammatory therapies for IBD, incidence intestinal and need resection have not significantly changed. To clarify contribution haematopoietic-derived cells fibrosis, we prepared bone marrow (BM) chimeric mice (chimeras), which were reconstituted with BM derived from enhanced green fluorescent protein (EGFP)-transgenic or CC chemokine receptor 2...
Unresectable malignant bile duct stricture (often caused by unresectable pancreatic cancer and cholangiocarcinoma) can be drained via insertion of self-expandable metal stents (SEMS) during endoscopic retrograde cholangiopancreatography (ERCP). Because recurrent biliary obstruction (RBO) complications following stent delay chemotherapy other treatments, a longer time to RBO (TRBO) is desirable. Although TRBO has been reported among patients who undergo with larger diameter SEMS, smaller...
Abstract Following injury, skeletal muscle regenerates but fatty tissue accumulation is seen in aged or muscular dystrophies. Fibro/adipogenic progenitors (FAPs) are key players these events; however, the effect of primary cilia on FAPs remains unclear. Here, it reported that genetic ablation trichoplein (TCHP), a ciliary regulator, induces elongation after which promotes regeneration while inhibiting adipogenesis. The defective adipogenic differentiation attributed to dysfunction...
This study aimed to clarify whether pretreatment human equilibrative nucleoside transporter (hENT1) expressions in endoscopic ultrasonography-guided fine-needle aspiration biopsy (EUS-FNAB) specimens obtained from resectable, borderline and locally advanced unresectable pancreatic ductal adenocarcinoma (PDAC) are concordant with those the resected specimen after gemcitabine-based chemoradiotherapy (Gem-CRT) validate utility of hENT1 expression using EUS-FNAB samples as a prognostic marker.We...
Abstract The introduction of anti-inflammatory therapies has enabled substantial improvement disease activity in patients with inflammatory bowel diseases (IBD). However, IBD can lead to serious complications such as intestinal fibrosis and colorectal cancer. Therefore, novel reducing the development these are needed. Angiotensin II (Ang II) promotes tissue inflammation by stimulating production monocyte chemoattractant protein-1 (MCP-1) or proinflammatory cytokines. It plays a pivotal role...
Purpose: We report a combined technique consisting of thrombectomy and thromboaspiration for the treatment acute embolic occlusion superior mesenteric artery (SMA) at origin. Case: A 90-year-old female with chronic atrial fibrillation had sudden onset abdominal pain hematochezia due to origin SMA. Computed tomographic findings showed reversible bowel wall ischemia. performed mechanical using Solitaire FR revascularization device, self-expanding fully retrievable stent-based system...
Background: Endoscopic submucosal dissection (ESD) for superficial esophageal cancer is technically challenging, and research on predictive factors related to the difficulty in procedure limited. This study aimed investigate predicting ESD. Methods: retrospective analyzed 303 lesions treated at our institution between April 2005 June 2021. The following 13 were evaluated: sex, age, tumor location, localization, macroscopic type, size, circumference, preoperative diagnosis of histological...
Abstract Hereditary hemochromatosis (HH) is recognized as a progressive iron‐storage disorder, and leading to severe organ impairments, including liver cirrhosis. type 3 arises from mutations in the transferrin receptor 2 ( TFR2 ) gene. However, HH rare Asia, information regarding genetic associated phenotypes remains limited. Here, we reported case of Japanese patient with 3, novel homozygous mutation A 69‐year‐old woman presented our hospital hand joint pain was referred due impairment....
A 58-year-old man presented with an 8-year history of intermittent dysphagia. There was no other relevant medical history. barium esophagogram revealed a stenotic lesion in the middle and lower thoracic esophagus multiple intramural tracks [1]. Endoscopic examination annular stricture extending from 27 cm to 40 incisors, as well small orifices ([Fig. 1]).
Abstract A 71-year-old man on prednisolone for immunoglobulin (Ig) G4-related renal disease showed increased carbohydrate antigen (CA) 19–9 level; abdominal enhanced computed tomography (CT) a lesion in the left lateral segment and dilatation of peripheral biliary duct. He was referred to our hospital detailed examination suspected intrahepatic cholangiocarcinoma. CT magnetic resonance imaging findings were similar those However, endoscopic retrograde cholangiopancreatography smooth...
The survival rate of pancreatic ductal adenocarcinoma (PDAC) is very poor because early detection difficult. Extracellular vesicles (EVs) are released from cells associating with the cellular condition and circulated in blood. We aimed to identify EV proteins endoscopic ultrasound-fine needle aspiration (EUS-FNA) biopsy samples order develop novel biomarkers for PDAC.Extracellular were isolated EUS-FNA 40 PDAC patients six autoimmune pancreatitis (AIP) be used as a control. identified using...
An 88-year-old woman was referred to our hospital because of esophageal squamous cell carcinoma that had been detected by esophagogastroduodenoscopy. Computed tomography (CT) showed no abnormalities. Endoscopy revealed a half-circumferential, subtle, reddish lesion on the left side middle esophagus ([Video 1]). Chromoendoscopy with iodine dye made clear as an unstained area ([Fig. Endoscopic submucosal dissection (ESD) carbon dioxide insufflation performed. During ESD procedure, massive gas...
Abstract Adoption of interventional endoscopic procedures is increasing with prevalence diseases. However, medical radiation exposure concerning; therefore, protection for staff important. there limited information on the usefulness an additional lead shielding device during procedures. Therefore, we aimed to determine whether protects from radiation. An X-ray unit (CUREVISTA; Hitachi Medical Systems, Tokyo, Japan) over-couch system was used. Fluoroscopy-associated scattered measured using a...
A 73-year-old woman presented with symptoms of intermittent abdominal pain without hematochezia. Mild tenderness was noted on palpation over the right iliac fossa; however, all laboratory data, including C-reactive protein level, were normal. Computed tomography revealed a fatty tissue mass in transverse colon causing colonic intussusception ([Fig. 1]). Colonoscopy large ascending 2]). Endoscopic ultrasonography hyperechoic submucosal layer 3]). On contrast radiograph, semipedunculated seen...
A 68-year-old female patient was referred to our hospital with a 30-mm polyp in the second portion of duodenum found via esophagogastroduodenoscopy. The had an irregular, lobular surface and thick stalk. In addition, white dots were detected on surface. Magnifying endoscopy narrow-band imaging showed material deep loop-shaped microvessels dots. Endoscopic ultrasonography hypoechoic elevated lesion from mucosal layer, feeding vessel traversing stalk supply head polyp. biopsy did not provide...
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related death worldwide. The accuracy PDAC diagnosis based on endoscopic ultrasonography-guided fine-needle aspiration cytology can be strengthened by performing rapid on-site evaluation (ROSE). However, ROSE only performed in limited number facilities, due to relative lack available resources or cytologists with sufficient training. Therefore, we developed the Mathematical Technology for Cytopathology (MTC) algorithm,...
Background and study aims Magnifying endoscopy with narrow band imaging (M-NBI) was developed to diagnose Barrett's esophageal adenocarcinoma (BEA); however, this method remains challenging for inexperienced endoscopists. We aimed evaluate a modified M-NBI technique that included spraying acetic acid (M-AANBI). Patients methods Eight endoscopists retrospectively examined 456 endoscopic images obtained from 28 patients 29 endoscopically resected BEA lesions using three validation schemes:...
Abstract Adult hypertrophic pyloric stenosis (AHPS) is a rare disease and presents as obstruction. Double pylorus also condition due to gastroduodenal fistula connecting from the gastric antrum duodenum. A 42‐year‐old woman without history of vomiting in infancy presented with postprandial abdominal distension repeated vomiting. Abdominal computed tomography showed dilatation wall thickening distal stomach. Endoscopy contrast gastrography revealed outlet obstruction an ulcer antral region....
Abstract Background and study aims Female sex has been identified as a factor increasing patients’ pain during colonoscopy. The aim of this randomized controlled was to investigate the efficacy small-caliber colonoscope, PCF-PQ260 L, for limiting in women unsedated Patients methods Women who underwent colonoscopy were randomly allocated either or standard colonoscope group. primary outcome overall secondary outcomes maximum procedural measures. In addition, effects type analysed using...
Pancreatic cancer is associated with high mortality and its rates of detection are very low; as such, the disease typically diagnosed at an advanced stage. A number risk factors for pancreatic have been reported may be used to identify individuals development this disease.The aim prospective, observational trial evaluate a scoring metric systematic early in Mie Prefecture, Japan.Eligible patients aged 20 years older will referred from participating clinics Tsu City area Faculty Medicine,...