A5101752827- Helicobacter pylori-related gastroenterology studies
- Cardiovascular Function and Risk Factors
- Gastrointestinal disorders and treatments
- Cardiac Valve Diseases and Treatments
- Galectins and Cancer Biology
- Microbial Metabolites in Food Biotechnology
- Sarcoidosis and Beryllium Toxicity Research
- Musculoskeletal synovial abnormalities and treatments
- Coronary Interventions and Diagnostics
- Oral and Maxillofacial Pathology
- Abdominal vascular conditions and treatments
- Lung Cancer Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Cardiac Imaging and Diagnostics
- Systemic Lupus Erythematosus Research
- Cancer Diagnosis and Treatment
- Cardiac Health and Mental Health
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Material Properties and Processing
- Ear and Head Tumors
- Multiple and Secondary Primary Cancers
- Metastasis and carcinoma case studies
- Intraperitoneal and Appendiceal Malignancies
- Minimally Invasive Surgical Techniques
- Vascular Malformations and Hemangiomas
Chiba University Hospital
2015-2021
Japanese Red Cross Society Wakayama Medical Center
2020
Chiba Cerebral and Cardiovascular Center
2017
Higashihiroshima Medical Center
2012
The University of Tokyo
1983-2010
Hokkaido University
2006-2010
Molecular Oncology (United States)
2009
Kawasaki Medical School
2007
Shiga Medical Center for Adults
2004
National Institute of Technology, Tomakomai College
2001
The Helicobacter pylori CagA bacterial oncoprotein plays a critical role in gastric carcinogenesis. Upon delivery into epithelial cells, causes loss of polarity and activates aberrant Erk signaling. We show that CagA-induced activation results senescence mitogenesis nonpolarized polarized respectively. In oncogenic stress, up-regulation the p21(Waf1/Cip1) cyclin-dependent kinase inhibitor, induction senescence. CagA-driven signals prevent expression by activating guanine nucleotide exchange...
Infection with cagA-positive Helicobacter pylori is the strongest risk factor for development of gastric carcinoma. The cagA gene product CagA, which delivered into epithelial cells, specifically binds to and aberrantly activates SHP-2 oncoprotein. CagA also interacts inhibits partitioning-defective 1 (PAR1)/MARK kinase, phosphorylates microtubule-associated proteins destabilize microtubules thereby causes polarity defects. In light notion that are not only required regulation but essential...
Helicobacter pylori ( H. ) cagA ‐positive strains are associated with gastritis, peptic ulcerations, and gastric adenocarcinoma. Upon delivery into epithelial cells, the ‐encoded CagA protein specifically binds aberrantly activates SHP‐2 oncoprotein in a manner that is dependent on tyrosine phosphorylation. CagA‐deregulated then elicits aberrant Erk activation while causing an elongated cell shape known as hummingbird phenotype. In polarized also to PAR1b/MARK2 inhibits PAR1b kinase...
Helicobacter pylori CagA plays a key role in gastric carcinogenesis. Upon delivery into epithelial cells, binds and deregulates SHP-2 phosphatase, bona fide oncoprotein, thereby causing sustained ERK activation impaired focal adhesions. also inhibits PAR1b/MARK2, one of the four members PAR1 family kinases, to elicit polarity defect. In nonpolarized induces hummingbird phenotype, an extremely elongated cell shape characterized by rear retraction This morphological change is dependent on...
Purpose: We report a combined technique consisting of thrombectomy and thromboaspiration for the treatment acute embolic occlusion superior mesenteric artery (SMA) at origin. Case: A 90-year-old female with chronic atrial fibrillation had sudden onset abdominal pain hematochezia due to origin SMA. Computed tomographic findings showed reversible bowel wall ischemia. performed mechanical using Solitaire FR revascularization device, self-expanding fully retrievable stent-based system...
Abstract We describe the case of a patient who developed right thoracic empyema 1 year after laparoscopic cholecystectomy. The experienced chest pain and swelling; radiography CT showed an intrathoracic abscess penetrating extrathoracic space presence metal clips over diaphragm. After drainage subcutaneous abscess, fluid accumulation decreased; bacterial examination no positive findings. Another later, patient's condition relapsed. thought that may have been caused by endoclips had migrated....
A 61-year-old man was admitted to our hospital with a 6-month history of productive cough. He, along his wife, had been involved Shiitake mushroom cultures for period 12 years. On admission, chest radiography showed bilateral fine-nodular shadow and CT scans reticulonodular opacities ground-glass appearance predominantly in the subpleural area both lungs, mass left S6. Resected pathological specimens obtained by lower lobectomy revealed lung adenosquamous carcinoma (stage IB), interstitial...
Intrapineal neurons and intracapsular intrapineal myelinated fibers were studied by light microscopy in male cotton rats (Sigmodon hispidus) at various postnatal ages. Until 300 days of age, are encountered mainly the distal third organ; neuronal nuclei largest this region. The remaining regions contain only a few with smaller nuclei. In all regions, nuclear sizes increase, numbers reduce half until 100-200 days. Neurons thus consist different populations cells, aging changes seem to be...
Purpose: To compare the performance of phased-array coil (PAC) with that single-loop (SLC) in magnetic resonance (MR) imaging breast. Materials and Methods: MR was performed a 1.5T imager. A phantom study right element two coils to obtain their signal-to-noise ratio (SNR). images breasts 12 patients breast lesions were obtained PAC SLC, these reviewed by five readers blind evaluation employing scoring system for assessing overall image quality. Results: In study, SLC exhibited SNR 1.82 times...