A5018473694- Blood Pressure and Hypertension Studies
- Shape Memory Alloy Transformations
- Microstructure and Mechanical Properties of Steels
- Congenital Heart Disease Studies
- Heart Rate Variability and Autonomic Control
- Magnetic Properties and Applications
- Reproductive Biology and Fertility
- Nutrition and Health in Aging
- Sperm and Testicular Function
- Analytical Chemistry and Chromatography
- Gastrointestinal disorders and treatments
- Catalytic Processes in Materials Science
- Immunotherapy and Immune Responses
- Coronary Artery Anomalies
- Cardiovascular Health and Disease Prevention
- Dyeing and Modifying Textile Fibers
- Neuroendocrine Tumor Research Advances
- Industrial Gas Emission Control
- Lung Cancer Research Studies
- Neuroscience and Neuropharmacology Research
- Hormonal Regulation and Hypertension
- Connective tissue disorders research
- Crystal Structures and Properties
- Renal and related cancers
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Showa University
2021-2024
Mie University
1994-2024
Nippon Kayaku (Japan)
1989-2024
Mie Chuo Medical Center
2021-2024
Mie University Hospital
2024
Sanno Medical Center
2014-2022
BrightPath Biotherapeutics (Japan)
2020-2022
Tokushima University
2008-2018
Kyoto Prefectural University of Medicine
2018
Nihon University
2012-2017
NK911 is a novel supramolecular nanocarrier designed for the enhanced delivery of doxorubicin (DXR) and one successful polymer micelle systems to exhibit an efficient accumulation in solid tumours mice. The purpose this study was define maximum-tolerated dose (MTD) dose-limiting toxicities (DLTs) evaluate its pharmacokinetic profile man. given intravenously patients with every 3 weeks using infusion pump at rate 10 mg DXR equivalent min−1. starting 6 m−2, escalated according accelerated...
To compare the prediction of mortality by ambulatory blood pressure monitoring and screening measurements in a general population.A prospective cohort study.We obtained data for 1542 subjects (565 men 977 women) aged > or = 40 years who were followed up to 8.1 (mean 5.1 years). Subjects subdivided into five groups according their levels. The prognostic significance was examined Cox proportional hazards regression model.The association between level more distinctive than it pressure. risk...
An extract of the crude drug “ukon”, rhizomes CURCUMA LONGA, exhibited intense preventive activity against carbon tetrachloride-induced liver injury IN VIVO and VITRO. The was subjected to fractionation by monitoring VITRO assay methods employing tetrachloride- galactosamine-produced cytotoxicity in primary cultured rat hepatocytes. Curcuminoids were shown possess significant antihepatotoxic action. protective effects some analogues ferulic acid p-coumaric acid, probable metabolites...
The purpose of this study was to propose reference values, from a viewpoint prognostic significance, for blood pressure (BP) measured at home with semiautomated device (home BP measurement) differentiate normotension and hypertension. We obtained measurements 1,913 population-based subjects aged 40 years over in rural Japanese community followed up their survival mean duration 5.0 years. There were 141 deaths during the follow-up period. association between baseline values overall mortality...
To evaluate the distribution, reference values and day-to-day variation of blood pressure untreated subjects measured at home.Cross-sectional study a cohort.General community in northern Japan.Blood was 871 (mean +/- SD age 46.0 19.5 years, range 7-98, constituting 38.7% local population Uchikawama region, Ohasama) who were not receiving antihypertensive medication.Subjects their own home least three times 19.7 8.4) each morning using semi-automatic oscillometric measuring device. Screening...
The accuracy and performance of the A&D TM 2421, a new ambulatory blood pressure (BP) monitoring device using both cuff-oscillometric method (O) Korotkoff sound (K) were evaluated. was tested for under static dynamic conditions by simultaneous comparison with two observers standard mercury column sphygmomanometer (standard method) objective recording (ORM). also evaluated ordinary conditions. mean differences in BP from K-method -1.2 +/- 4.7 mm Hg systole 1.3 diastole (n = 323, SD) those...
Background and Purpose We conducted a cross-sectional epidemiological survey using ambulatory blood pressure monitoring brain MRI in cohort from northern Japan to determine whether an inappropriately low nocturnal pressure, or excess fall might be responsible for silent cerebrovascular lesions the elderly. Methods Untreated subjects over 55 years under 64 of age (late middle age; 24 men 46 women, 60% eligible people) 65 75 (elderly; 29 52 91% participated study. evaluated relationship...
Abstract Raman spectra of p ‐cresol, a model compound for tyrosine, were measured in solutions various solvents, paying special attention to the effects hydrogen bonding on bands 1300–1150 cm −1 region. The frequency ν 7a (CO stretch) band was found be sensitive state at phenolic hydroxyl group. It occurs 1275–1265 proton‐donating states, 1240–1230 proton‐accepting states and around 1255 weakly or non‐hydrogen‐bonding states. This relationship between 7a′ verified L‐tyrosine its derivatives...
Molecule targeting therapy using somatostatin (SS) analogues has become a widely accepted modality to treat neuroendocrine tumors (NETs), particularly gastrointestinal (GI) and pancreatic endocrine tumors. On the other hand, little is known about expression of receptor (SSTR) subtypes in carcinomas (NECs). We investigated SSTR (SSTR-1, 2A, 3, 4 5) real-time reverse transcription polymerase chain reaction (RT-PCR) method immunohistochemistry 32 neoplasms (9 NET G1, 2 G2, 18 NECs G3 3 mixed...
Abstract Clinical and experimental studies have shown that sodium glucose co-transporter 2 inhibitors (SGLT2i) contribute to the prevention of diabetic kidney disease progression. In order clarify its pharmacological effects on molecular mechanisms underlying development disease, we administered different doses SGLT2i, ipragliflozin, type mice. A high-dose ipragliflozin treatment for 8 weeks lowered blood levels reduced urinary albumin excretion. High- low-dose both inhibited renal...
1. The factors influencing the seasonal variation in blood pressure measured at home normotensive women were examined. 2. Sixteen female subjects (56.3 ± 7.9 years old, mean SD) their and pulse rate each morning for more than 20 times per month least 1.5 years. Blood body weight also determined office once or twice a that period. Monthly means of outdoor indoor temperatures daytime length obtained from Meteorological Observatory. single cosinor method was used to evaluate circannual rhythm....
Since an extract of the crude drug “inchinko”, buds Artemisia capillaris, showed significant antihepatotoxic activity by means carbon tetrachloride-induced liver lesion in vivo and vitro, was fractionated monitoring to yield a number flavonoids coumarin (6,7-dimethylesculetin). Antihepatotoxic effects these constituents were determined vitro assay methods using tetrachloride- galactosamine-induced cytotoxicity primary cultured rat hepatocytes. Some analogues dimethylesculetin also assayed...
Context: To develop a personalized peptide vaccine (PPV) for recurrent ovarian cancer patients and evaluate its efficacy from the point of view overall survival (OS), Phase II study PPV was performed.
Objective To validate the efficacy of salvage hormonal therapy in men with non‐obstructive azoospermia at their second microdissection testicular sperm extraction. Methods This was a multi‐institutional study registered Japanese University Hospital Medical Information Network clinical trial center. After 1 month human chorionic gonadotropin (5000 IU, three times week), patients were treated recombinant follicle‐stimulating hormone (150 week) and for next 3 months. Three samples obtained...