A5042858128- Renal Diseases and Glomerulopathies
- S100 Proteins and Annexins
- Acute Ischemic Stroke Management
- Advanced Glycation End Products research
- Mechanical Circulatory Support Devices
- Dialysis and Renal Disease Management
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Electroconvulsive Therapy Studies
- Renal Transplantation Outcomes and Treatments
- Gastrointestinal disorders and treatments
- Sodium Intake and Health
- Vasculitis and related conditions
- Hormonal Regulation and Hypertension
- Chemotherapy-induced organ toxicity mitigation
- Chronic Kidney Disease and Diabetes
- Blood Pressure and Hypertension Studies
- Sarcoidosis and Beryllium Toxicity Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Electrolyte and hormonal disorders
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Biomedical Research and Pathophysiology
- Hematopoietic Stem Cell Transplantation
- Eating Disorders and Behaviors
- Pediatric Urology and Nephrology Studies
- Adolescent and Pediatric Healthcare
Kyoto Prefectural University of Medicine
2012-2025
Japanese Red Cross Society Kyoto Daini Hospital
2015-2025
Shizuoka General Hospital
2017
Community Medical Center
2011
Abstract Clinical and experimental studies have shown that sodium glucose co-transporter 2 inhibitors (SGLT2i) contribute to the prevention of diabetic kidney disease progression. In order clarify its pharmacological effects on molecular mechanisms underlying development disease, we administered different doses SGLT2i, ipragliflozin, type mice. A high-dose ipragliflozin treatment for 8 weeks lowered blood levels reduced urinary albumin excretion. High- low-dose both inhibited renal...
Summary Background and objectives S100A12 is an endogenous receptor ligand for advanced glycation end products. Cardiovascular disease remains a major cause of morbidity mortality in patients with chronic kidney disease. In this study, we report cross-sectional data on 550 hemodialysis assess the relationship between plasma level cardiovascular Design, setting, participants, & measurements A study maintenance was conducted. We investigated past history quantified protein all...
Anorexia nervosa (AN) is an eating disorder characterized by restriction of energy intake leading to a significantly low body weight, and intense fear gaining weight. Severe electrolyte changes such as hypokalemia hypophosphatemia; alterations in water metabolism hyponatremia edema, can occur patients with AN. Hypokalemia chronic volume depletion may lead acute kidney injury (AKI) disease (CKD). There are few reports AN who require maintenance dialysis. Therefore, it unclear whether...
The pathophysiological mechanisms of cisplatin nephrotoxicity include the reduction renal blood flow, as well tubular epithelial cell toxicity. objective this study was to investigate influence lower pressure and decreased food intake on incidence nephrotoxicity.We conducted a retrospective cohort at university hospital between 2011 2012. We identified hospitalized adult patients with head neck cancer, esophageal or gastric who received intravenous administration. primary outcome defined...
Hyponatremia is a common finding after subarachnoid hemorrhaging (SAH) and can be caused by either cerebral salt-wasting syndrome (CSWS) or of inappropriate antidiuretic hormone (SIADH). Distinguishing between these two entities difficult because they have similar manifestations, including hyponatremia, serum hypo-osmolality, high urine osmolality. We herein report the case 60-year-old man who suffered from SAH complicated hyponatremia. During his initial hospitalization, he was diagnosed...
Peritoneal fibrosis leads to discontinuation of peritoneal dialysis. Although aldosterone promotes tissue in many organs, its contribution and the underlying mechanism are poorly understood. The present study investigated direct effect on cultured rat fibroblasts (RPFs).The expression synthase (CYP11B2), mineralocorticoid receptors (MRs), 11beta-hydroxysteroid dehydrogenase 2 (11beta-HSD2), serum- glucocorticoid-inducible protein kinase 1 (SGK1), connective growth factor (CTGF) mRNA was...
OBJECTIVE: This open-label, randomized controlled trial investigated the effects of cilnidipine, an L/N-type calcium channel blocker (CCB), in patients with chronic kidney disease (CKD). METHODS: Sixty CKD and well-controlled hypertension being treated a renin—angiotensin system (RAS) inhibitor L-type CCB (L-CCB) were randomly assigned either to switch from L-CCB cilnidipine after 4-week observation period or continue treatment. Blood pressure, heart rate renal function monitored for 12...
<i>Background:</i> S100A12 is an endogenous ligand of the receptor for advanced glycation end products (RAGE). Plasma levels are high in end-stage renal disease (ESRD) patients undergoing maintenance hemodialysis (HD). Peripheral arterial (PAD) common HD and associated with increased cardiovascular morbidity mortality rates this population. To date, however, no study has specifically assessed relationship between plasma PAD patients. <i>Methods:</i> We conducted a...
Abstract Background S100A12 protein is an endogenous receptor ligand for advanced glycation end products. In this study, the plasma level was assessed as independent predictor of mortality, and its utility in clinical settings examined. Methods a previous cross-sectional levels were measured 550 maintenance hemodialysis patients to determine association between prevalence cardiovascular diseases (CVD). prospective risk mortality within two-year period determined. An integer scoring system...
Hypoparathyroidism, sensorineural deafness, and renal dysplasia (HDR) syndrome is a rare autosomal dominant disease caused by GATA3 mutations. Although several cases with variable features have been reported, the presence of histological changes within glomeruli in adult patients unclear. We herein report an case HDR novel p.C288W (TGC>TGG) missense mutation GATA3. His histology showed membranoproliferative glomerulonephritis-like glomerular lesion. Additional analyses will be needed to...
Aims Anemia, which might contribute to pathogenesis of kidney dysfunction, is a common finding in patients with type 2 diabetes. The aim this study was investigate if hemoglobin concentration associated the degree change urinary albumin-creatinine ratio or development albuminuria Methods We measured 470 (296 men and 174 women) consecutive diabetic without albuminuria. performed follow-up assess progression albuminuria, interval 3.0 years. Then we evaluated relationships between using...
A 30-year-old woman with myelodysplastic syndrome underwent allogeneic hematopoietic stem cell transplantation (HSCT) derived from her HLA-matched sister six years previously. She received preconditioning total body irradiation renal shielding and was subsequently administered cyclosporin (CyA) as prophylaxis against graft-versus-host disease (GVHD). Four months after HSCT, asymptomatic proteinuria glomerular hematuria developed during CyA tapering without obvious extrarenal involvements of...
We report the case of a Japanese family suffering from familial juvenile hyperuricemic nephropathy (FJHN) due to rare missense mutation uromodulin (UMOD) gene. An 18-year-old male presented with gout, hyperuricemia, and stage 3 chronic kidney disease. Mostly, FJHN is caused by altering cystine residue UMOD/Tamm-Horsfall protein. However, in present case, T688C was identified exon 4, resulting amino acid substitution arginine replacing tryptophan at position 230 (Trp230Arg). This also found...
Abstract Dietary salt restriction is essential for managing fluid retention in patients with chronic kidney disease (CKD). In this retrospective cohort study, we investigated weight loss from the perspective of status CKD during a 7-day hospitalization period while consuming low-salt diet (5 g/day). Among 311 patients, median (interquartile range, maximum) was 0.7 (0.0–1.4, 4.7) kg on Day 4 and 1.0 (0.3–1.7, 5.9) 7. Patients were classified into quartiles based pre-hospital urinary excretion...
症例は68歳，男性．主訴は，全身倦怠感，PD排液異常．既往歴に関節リウマチを認める．現病歴：慢性腎不全（原疾患不明）のためSMAP法にてPDカテーテル挿入．その後2006年10月からCAPDにて当院で透析導入．2年9か月のPD歴で，出口部感染や腹膜炎の既往を認めず経過していた．2009年6月X日にエリスロポエチン注射と採血を実施，特に体調不良の訴えもなく帰宅した．後日判明した採血結果でCRPが31.24mg/dLと異常高値を示していた．その前後に腹痛なく，排液混濁も認めなかったが，同年7月10日早朝より「腹痛はないが，突然に透析液の注入途中から肛門より排液する」との訴えで診察依頼があり，独歩にて救急来院した．PDカテーテルから食物残渣を含む混濁した排液を確認，穿孔性腹膜炎を疑い，緊急開腹手術をした．カテーテル周囲で瘻孔形成し，癒着した消化管の剥離に難渋して穿孔部位の同定は困難であった．臨床経過から本症例の穿孔性腹膜炎の機序は次のとおりと推察する．すなわち，憩室炎などを原因にすでに潜在した腹膜炎を約2週間前に発症し，被覆した腸間膜とカテーテルが治癒過程において癒着．その後，機械的刺...
Glomerulopathy with fibronectin deposits (GFND) is a rare hereditary kidney disease autosomal dominant inheritance. A 21-year-old woman who had been diagnosed GFND 10 years ago was admitted for investigation of rapid decline in her renal function, hemolytic anemia, and cardiac dysfunction. biopsy showed accompanied by extraglomerular vascular lesions. Comprehensive treatments against hypertension anemia improved the function. Although there have few reports lesions GFND, we suspect that...