A5088268371- Helicobacter pylori-related gastroenterology studies
- Inflammatory Bowel Disease
- Microscopic Colitis
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Screening and Detection
- Genetic factors in colorectal cancer
- Mycobacterium research and diagnosis
- Esophageal Cancer Research and Treatment
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Cancer Genomics and Diagnostics
- Esophageal and GI Pathology
- Liver Diseases and Immunity
- Inflammatory mediators and NSAID effects
- Immune Cell Function and Interaction
- Pancreatic and Hepatic Oncology Research
- Cytomegalovirus and herpesvirus research
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- IL-33, ST2, and ILC Pathways
- RNA Research and Splicing
- Antiplatelet Therapy and Cardiovascular Diseases
Hamamatsu University School of Medicine
2016-2025
Weatherford College
2023-2024
Japan Society for the Promotion of Science
2023
Bavarian Nordic (Denmark)
2023
University of Michigan
2014-2016
Michigan United
2015
Health First
2010
Hamamatsu University
2009
Hamamatsu Medical Center
2004
Tokai University
2003
Summary Background Acid inhibitory effects of proton pump inhibitors ( PPI s) are influenced by CYP 2C19 genotype. In contrast, the potent acid inhibition vonoprazan is not Aim To compare and esomeprazole in relation to Methods Twenty‐eight healthy Japanese volunteers [7 poor metabolisers PM s), 11 intermediate IM 10 rapid RM s)] received four different regimens a randomised crossover manner: (i) 20 mg twice daily (b.d.), (ii) daily, (iii) b.d. (iv) daily. The timing each dosing was 1 h...
Backgrounds/Aims: Vonoprazan (VPZ) is the first clinically available potassium competitive acid blocker. This class of agents provides faster and more potent inhibition than proton pump inhibitors. Most strains Helicobacter pylori are sensitive to amoxicillin. We hypothesized that dual therapy with VPZ amoxicillin would provide sufficient eradication rate for H. infection. To evaluate this, we compared by VPZ/amoxicillin standard triple VPZ/amoxicillin/clarithromycin therapy. Methods:...
Bone-marrow-derived macrophages are divided into two phenotypically and functionally distinct subsets, M1 M2 macrophages. Recently, it was shown that adoptive transfer of M2-polarized peritoneal reduced the severity experimental colitis in mice. However, is still unclear whether possess same ability to be polarized cells with different phenotypes cytokine production patterns as bone-marrow-derived To address this question, we examined determined specific profiles each phenotype. We showed...
Unresectable malignant bile duct stricture (often caused by unresectable pancreatic cancer and cholangiocarcinoma) can be drained via insertion of self-expandable metal stents (SEMS) during endoscopic retrograde cholangiopancreatography (ERCP). Because recurrent biliary obstruction (RBO) complications following stent delay chemotherapy other treatments, a longer time to RBO (TRBO) is desirable. Although TRBO has been reported among patients who undergo with larger diameter SEMS, smaller...
Although autoimmune gastritis (AIG) is generally considered relatively rare, we frequently encounter AIG among patients at to our hospital who have experienced least two episodes of Helicobacter pylori eradication failure.We investigated the incidence in consecutive consulted department for H. with reference history.A total 404 visited pylori-specific out-patient unit from June 2015 2017 were enrolled. Of these, 137 treatment-naive, 47 had failed treatment once (single failure), and 220...
We previously reported that fecal cyclooxygenase 2 (COX-2) mRNA assay, detecting COX-2 in feces, is useful for identifying subjects with colorectal cancer (CRC). To further improve the sensitivity, we evaluated usefulness of combination and matrix metalloproteinase 7 (MMP-7) assays as a marker CRC. The study cohort included 62 patients CRC 29 control without neoplasia. RNA was isolated from routinely collected samples. expression levels MMP-7 mRNAs were determined by nested reverse...
Elevated Microsatellite Alterations at Selected Tetranucleotide repeats (EMAST) is a genetic signature found in up to 60% of colorectal cancers (CRCs) that caused by somatic dysfunction the DNA mismatch repair (MMR) protein hMSH3. We have previously shown vitro recognition 5-fluorouracil (5-FU) within and subsequent cytotoxicity was most effective when both hMutSα (hMSH2-hMSH6 heterodimer) hMutSβ (hMSH2-hMSH3 MMR complexes were present, compared > alone. tested if patients with EMAST CRCs...
Abstract Background Schlafen 11 (SLFN11) was recently identified as a dominant determinant of sensitivity to DNA-targeting agents including platinum-based drugs. SLFN11 also reportedly enhances cellular radiosensitivity. In this study, we examined the prognostic value expression in esophageal squamous cell carcinoma (ESCC) patients treated with definitive chemoradiotherapy (dCRT), platinum derivative nedaplatin. Methods Seventy-three ESCC who received dCRT were examined. analyzed pre-dCRT...
Abstract We evaluated the association between endoscopic scores of colonic inflammation and fecal calprotectin (FC), immunochemical occult blood test (FIT), C-reactive protein (CRP) in patients with ulcerative colitis (UC). Endoscopic reflecting most severe lesion [maximum Mayo Subscore (M-MES) Ulcerative Colitis Index Severity (UCEIS)] those entire colon [sum MES (S-MES) Colonoscopic (UCCIS)] were evaluated. FC, FIT, CRP measured, their four was 78 complete colonoscopies (66 UC patients)...
Abstract Background Owing to the lack of definite diagnostic modalities, it is challenging distinguish malignant cases cholangiocarcinoma (CCA), which often causes biliary tract obstruction, from benign ones. Here, we investigated a novel lipid biomarker CCA in bile‐derived small extracellular vesicles (sEVs) and developed simple detection method for clinical application. Methods Bile samples seven patients with diseases (hilar = 4, distal 3) eight (gallstones 6, primary sclerosing...
Drug–drug interaction between antiacid and antiplatelet agents has not been fully elucidated. Vonoprazan, a new potassium competitive acid blocker, available in Japan. CYP2C19 CYP3A4 are involved the metabolism of clopidogrel, prasugrel, esomeprazole, vonoprazan. Using P2Y12 assay, we compared effects vonoprazan esomeprazole on functions clopidogrel or prasugrel 31 healthy Japanese volunteers (14 homo‐extensive (homo‐EMs), nine hetero‐extensive (hetero‐EMs), eight poor metabolizers (PMs))....
Strong reactive oxygen species (ROS) suppression in cancer stem-like cell components various solid tumors is associated with therapeutic resistance. In this study, we investigated the influence of CD44v8-10 expression on overall survival esophageal squamous carcinoma (E-SCC) patients after definitive chemoradiotherapy (dCRT) and radio-sensitivities E-SCC lines treated or without sulfasalazine, a CD44v8-10-xCT-GSH axis inhibitor.Seventy-three who received dCRT were examined retrospectively....
<b><i>Background:</i></b> When administered at a standard dose, proton pump inhibitors (PPIs) do not always provide sufficient acid inhibition for all subjects, particularly in extensive metabolizers (EMs) of CYP2C19. Whether esomeprazole dose 20 mg four times daily dosing (q.i.d.) can attain throughout 24 h EMs remains unclear. We therefore investigated the efficacy q.i.d. inhibition. <b><i>Methods:</i></b> In randomized cross-over design, 30...
We previously reported that a faecal cyclooxygenase-2 (COX-2) mRNA assay was useful for identifying colorectal cancer (CRC). This study sought to investigate the factors contribute COX-2 expression in subjects with CRC. The cohort comprised 78 patients CRC and 36 control subjects. expressions of COX-2, β-2-microglobulin (B2M), carcinoembryonic antigen (CEA), E-cadherin (E-cad), CD45 faeces tissue were determined by quantitative real-time RT–PCR. level significantly higher than controls. A...
To examine whether second generation of colon capsule endoscopy (CCE-2) is acceptable for assessing the severity mucosal inflammation and evaluating healing using CCE-2 able to predict outcome in ulcerative colitis (UC) patients, especially clinical remission.A total 30 consecutive UC patients remission were enrolled undergo CCE-2. Clinical was defined as activity index (CAI) ≤ 4 according Rachmilewitz index. The rate observation cleansing level evaluated. Severity assessed Mayo endoscopic...
An inverted Meckel's diverticulum is a rare gastrointestinal congenital anomaly that difficult to diagnose prior surgery and presents with anemia, abdominal pain, or intussusception. Here, we report the case of 57-year-old men an diverticulum, who was preoperatively diagnosed using double-balloon enteroscopy. He had repeatedly experienced epigastric pain for 2 mo. Ultrasonography computed tomography showed intestinal wall thickening in pelvis. Double-balloon enteroscopy via anal route...
In 2012, Japan approved the use of a tag-less patency capsule (PC), which evaluates gastrointestinal before small-bowel endoscopy (SBCE). This study aimed to evaluate validity our modification on passage criteria for this PC in clinical practice. We retrospectively enrolled 326 consecutive patients who underwent examination SBCE. If X-ray could not reveal body during judgement time (30-33 h after ingestion), we defined it as 'estimated patency' and performed employed plain computed...
A phase II study of second-generation photodynamic therapy (PDT) using talaporfin sodium has shown excellent treatment results for esophageal cancer with local failure after chemoradiotherapy (CRT) or radiotherapy (RT). However, only a few studies have reported this in clinical practice. This aimed to confirm the efficacy and safety salvage PDT various situations. Twelve patients definitive CRT RT who underwent were enrolled from April 2016 January 2020. Overall, 10 (83.3%) achieved complete...