A5055525259- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Metastasis and carcinoma case studies
- Tracheal and airway disorders
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Liver Disease Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Nutrition and Health in Aging
- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Radiation Dose and Imaging
- Vascular Malformations and Hemangiomas
- Genetic factors in colorectal cancer
- Synthesis and Reactions of Organic Compounds
- Metabolism and Genetic Disorders
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Synthesis of heterocyclic compounds
Hamamatsu University School of Medicine
2015-2024
The Japanese Society of Gastroenterological Surgery
2021
Tachikawa Hospital
2020
Kagoshima University
2017
Morinomiya Hospital
2017
Osaka University
2015
Dokkyo Medical University Saitama Medical Center
2015
Koga Hospital
2009-2014
Hamamatsu University
2006-2012
Fujita Health University
2008-2011
Abstract The aim of this study was to investigate the inhibitory effect TSU68 [(Z)-5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid; SU6668], an inhibitor vascular endothelial growth factor receptor 2, platelet-derived β, and fibroblast 1 (FGFR1), on colon cancer liver metastasis, test hypothesis that modulates microenvironment in before formation metastasis. First, we implanted highly metastatic human TK-4 orthotopically into cecal walls nude mice,...
Abstract A reduced expression level of the cyclin-dependent kinase inhibitor p27Kip1 is associated with increased tumor malignancy and poor prognosis in individuals various types cancer. To investigate basis for this relation, we applied microarray analysis to screen genes differentially expressed between p27+/− parental (p27+/+) HCT116 human colon carcinoma cells. Expression gene G protein–coupled receptor 48 (GPR48) was Forced GPR48 both vitro invasive activity lung metastasis potency In...
Control of liver metastasis is an important issue in the treatment colorectal cancer (CRC). MicroRNAs have been shown to be involved development many cancers, but little known about their role process metastasis. We compared miRNA expression between primary tumors and identify those Cancer cells were isolated from formalin-fixed paraffin-embedded CRC samples corresponding metastatic six patients using laser capture microdissection, was analyzed TaqMan arrays. The most abundant with miR-122....
Tumour stroma has important roles in the development of colorectal cancer (CRC) metastasis. We aimed to clarify microRNAs (miRNAs) and their target genes CRC liver metastasis.Tumour was isolated from formalin-fixed, paraffin-embedded tissues primary CRCs with or without metastasis by laser capture microdissection, miRNA expression analysed using TaqMan arrays.Hierarchical clustering classified 16 into two groups according existence synchronous Combinatory prediction identified tenascin C as...
Cardiovascular manifestations in 48 patients with systemic lupus erythematosus were investigated by means of echocardiography and other non-invasive cardiac function tests. During the mean follow-up period 17 months, 94 per cent showed abnormalities Pericardial effusion, a most frequent abnormality, was noted 53 at active phese 12 inactive phase. In normotensive patients, echocardiographic values ratio pre-ejection to left ventricular ejection time (PEP/LVET) changed toward normal range...
Acetylcholinesterase inhibitors (AChIs) are widely used in the treatment of mild-to-moderate Alzheimer's disease (AD), but their cholinergic effects could generate adverse side cardiovascular system. This report presents cases 2 patients who experienced cardiac rhythm with QT prolongation caused by Donepezil. Both them improved to original and shortened intervals after discontinuation The present suggest that Donepezil induce on careful consideration is needed for treated
Tumor angiogenesis plays a critical role in colorectal cancer progression. Recent randomized clinical trials have revealed the additive effect of bevacizumab, humanized monoclonal antibody against vascular endothelial growth factor (VEGF)-A, to conventional chemotherapy improved survival patients with metastatic cancer. However, number preclinical reports indicate development resistance anti-angiogenic therapy. In this study, we addressed effects anti-VEGF antibodies on and malignant...
It is demonstrated that cells can be classified by pattern recognition of the subcellular structure non-stained live cells, and was performed machine learning. Human white blood five types cancer cell lines were imaged quantitative phase microscopy, which provides morphological information without staining quantitatively in terms optical thickness cells. Subcellular features then extracted from obtained images as training data sets for The built classifier successfully WBCs (area under ROC...
Abstract Tob1, a member of the Tob/BTG family, is involved in control G1-S progression by suppressing cyclin D1 expression and acts as tumor suppressor gene. Tob1 was reported to have quick turnover through ubiquitin-proteasome pathway, but proteins this process are still unknown. We showed that Skp2, substrate-targeting subunit SCF (Skp1/Cul1/F-box protein) ubiquitin ligase complex, ubiquitin-dependent degradation Tob1. Skp2 interacted with facilitated ubiquitination intact cells well...
Eight cases of calcification the longitudinal ligament are reported. This condition can cause severe neurological symptoms, but diagnosis is not difficult if spine radiographed. Although etiology known, relationship to spondylosis deformans described. The reason why this seen rather frequently among Japanese clear. Some unknown factors, possibly dietary, may influence deposition calcium or bone in posterior ligament.
Abstract Introduction Laparoscopic gastrectomy ( LG ) with D2 or more extended lymphadenectomy for advanced gastric cancer is technically demanding. Collateral thermal damage to the pancreas secondary energized dissection during has been reported. We retrospectively compared pancreatic between and open OG by measuring amylase concentration of drainage fluid analyzing heat conductance a porcine model. Methods evaluated data 105 consecutive patients adenocarcinoma who underwent lymph node...
Background and purpose The microrchidia family CW ‐type zinc finger 2 gene ( MORC ) was newly identified as a causative of Charcot–Marie–Tooth disease CMT type 2Z in 2016. We aimed to describe the clinical mutational spectrum patients with harboring mutations Japan. Methods analyzed samples from 781 unrelated clinically diagnosed using deoxyribonucleic acid microarray or targeted resequencing by next‐generation sequencing, 434 mutation‐negative were subjected whole‐exome sequencing....
Abstract Background In April 2017, we launched the multidisciplinary Hamamatsu Perioperative Care Team (HOPE) for all surgical patients. We developed a reinforced intervention strategy, particularly esophagectomy. herein report outcomes of HOPE at 2 years after commencement. Methods A total 125 patients underwent esophagectomy and gastric conduit reconstruction esophageal or esophagogastric junction cancer between January 2014 December 2018 Department Surgery in University School Medicine....
Abstract Background Owing to the lack of definite diagnostic modalities, it is challenging distinguish malignant cases cholangiocarcinoma (CCA), which often causes biliary tract obstruction, from benign ones. Here, we investigated a novel lipid biomarker CCA in bile‐derived small extracellular vesicles (sEVs) and developed simple detection method for clinical application. Methods Bile samples seven patients with diseases (hilar = 4, distal 3) eight (gallstones 6, primary sclerosing...