A5102922667- Genetic factors in colorectal cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cancer Genomics and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Cytomegalovirus and herpesvirus research
- Sarcoma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Organ Transplantation Techniques and Outcomes
- Gastrointestinal disorders and treatments
- Liver Disease and Transplantation
- Gastric Cancer Management and Outcomes
- Alzheimer's disease research and treatments
- Colorectal Cancer Screening and Detection
- Gastrointestinal Tumor Research and Treatment
- Medical Imaging and Pathology Studies
- Soft tissue tumor case studies
- Colorectal Cancer Treatments and Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer, Hypoxia, and Metabolism
- Ear and Head Tumors
- Glioma Diagnosis and Treatment
- Genetic and Kidney Cyst Diseases
Hamamatsu University School of Medicine
2016-2025
Hamamatsu University Hospital
2012-2024
Hamamatsu University
2009-2024
Daiichi-Sankyo (Japan)
2024
University of Edinburgh
2024
Tokyo Medical and Dental University Hospital
2015
Fukuyama City Hospital
1993-2005
Kushiro City General Hospital
2002
Cancer Institute (WIA)
1993
Keio University
1989
Membranous nephropathy (MN) is a leading cause of nephrotic syndrome in adults. Autoantibodies against M-type phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A), which mainly belong to the IgG4 subclass, were reported as associated antibodies for development MN. Although PLA2R major target antigen idiopathic MN, prevalence MN patients seropositive Japan lower than that other countries. In this study, we conducted immunohistochemical analysis presence...
Tumour stroma has important roles in the development of colorectal cancer (CRC) metastasis. We aimed to clarify microRNAs (miRNAs) and their target genes CRC liver metastasis.Tumour was isolated from formalin-fixed, paraffin-embedded tissues primary CRCs with or without metastasis by laser capture microdissection, miRNA expression analysed using TaqMan arrays.Hierarchical clustering classified 16 into two groups according existence synchronous Combinatory prediction identified tenascin C as...
Control of liver metastasis is an important issue in the treatment colorectal cancer (CRC). MicroRNAs have been shown to be involved development many cancers, but little known about their role process metastasis. We compared miRNA expression between primary tumors and identify those Cancer cells were isolated from formalin-fixed paraffin-embedded CRC samples corresponding metastatic six patients using laser capture microdissection, was analyzed TaqMan arrays. The most abundant with miR-122....
Tumor angiogenesis plays a critical role in colorectal cancer progression. Recent randomized clinical trials have revealed the additive effect of bevacizumab, humanized monoclonal antibody against vascular endothelial growth factor (VEGF)-A, to conventional chemotherapy improved survival patients with metastatic cancer. However, number preclinical reports indicate development resistance anti-angiogenic therapy. In this study, we addressed effects anti-VEGF antibodies on and malignant...
The pathogenesis of abdominal aortic aneurysm (AAA) is characterized to be inflammation-associated degeneration vascular wall. Neovascularization regularly found in human AAA and considered play critical roles the development rupture AAA. However, little known about lymphangiogenesis purpose this study was demonstrate both angiogenesis Abdominal tissue harvested either from autopsy (control group) during open-repair surgery for (AAA group). Adventitial lymphatic vasa vasorum observed groups,...
<h3>BACKGROUND AND PURPOSE:</h3> The stiffness of intracranial tumors affects the outcome tumor removal. We evaluated 4 common by using MR elastography and tested whether had potential to discriminate firm preoperatively. <h3>MATERIALS METHODS:</h3> Thirty-four patients with meningiomas, pituitary adenomas, vestibular schwannomas, gliomas scheduled for resection were recruited elastography. On elastogram, mean maximum shear stiffnesses measured placing an ROI on tumor. Blinded findings,...
Cancer tissues reflect a greater number of pathological characteristics cancer compared to cells, so the evaluation can be effective in determining treatment strategies. Mass spectrometry imaging (MSI) evaluate and even identify molecules while preserving spatial information. Cluster analysis tissues’ MSI data is currently used phenotype heterogeneity tissues. Interestingly, it has been reported that does not always coincide with genotype HER2-positive breast cancer. We thus investigated...
Advances in cancer genome analysis technology have made individual profiling (CGP) possible. CGP can indicate the presence of hereditary tumors, which are caused by germline pathogenic variants oncogenes or tumor suppressor genes; if a is suspected, multigene panel testing (MGPT) performed. Genomic medicine thus plays an important role diagnosing tumors. A 41-year-old man presented with headache and depressive symptoms. Close examination revealed mass lesion cystic components right parietal...
Abstract Background Schlafen 11 (SLFN11) was recently identified as a dominant determinant of sensitivity to DNA-targeting agents including platinum-based drugs. SLFN11 also reportedly enhances cellular radiosensitivity. In this study, we examined the prognostic value expression in esophageal squamous cell carcinoma (ESCC) patients treated with definitive chemoradiotherapy (dCRT), platinum derivative nedaplatin. Methods Seventy-three ESCC who received dCRT were examined. analyzed pre-dCRT...
The imbalance between helper T (Th)1/Th2 cytokines has been observed in human inflammatory bowel disease and various animal models. Because interleukin (IL)-12 interferon-gamma (IFN-gamma) productions are known to be a hallmark of Th1-dominant intestinal inflammation such as 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis, we strictly addressed the roles IFN-gamma IL-12 development employing knockout mice with receptor (IFN-gammaR) or p40 gene disruptions administered neutralizing...