Sarcopenia impairs the outcome of patients with liver cirrhosis independently function reserves. The aim this study was to investigate whether rate skeletal muscle wasting predicts mortality in cirrhotic patients.This retrospective evaluated 149 who visited our hospital between March 2004 and September 2012. cross-sectional area at level third lumbar vertebra measured by computed tomography, from which index obtained for diagnosis sarcopenia. relative change per year (ΔSMA/y) calculated each...

The aim of this study was to determine whether skeletal muscle depletion predicts the prognosis patients with hepatocellular carcinoma (HCC) that is being treated sorafenib. We evaluated 40 consecutive HCC who received sorafenib treatment. cross-sectional area measured by computed tomography at third lumbar vertebra (L3), from which L3 index (L3 SMI) obtained. factors contributing overall survival, dose reduction, and discontinuation were analyzed using Cox proportional hazards model. SMI (p...

Sodium glucose cotransporter 2 inhibitors are expected to ameliorate the abnormalities associated with metabolic syndrome including non-alcoholic fatty liver disease. In this study, we investigated effects of sodium inhibitor tofogliflozin on development disease-related tumorigenesis in C57BL/KsJ-+Lepr db /+Lepr obese and diabetic mice. The direct human cancer cell proliferation were also evaluated. Mice administered diethylnitrosamine-containing water for weeks treated throughout...

Non-alcoholic fatty liver disease (NAFLD), which is strongly associated with metabolic syndrome, increasingly a major cause of hepatic disorder. Dipeptidyl peptidase (DPP)-4 inhibitors, anti-diabetic agents, are expected to be effective for the treatment NAFLD. In present study, we established novel NAFLD model mouse using monosodium glutamate (MSG) and high-fat diet (HFD) investigated effects DPP-4 inhibitor, teneligliptin, on progression Male MSG/HFD-treated mice were divided into two...

Abstract The platinum-based chemotherapeutic agent, oxaliplatin, is used to treat advanced colorectal cancer (CRC). Unfortunately, nearly all patients acquire resistance oxaliplatin after long-term use, limiting its therapeutic efficacy. Since COX-2 and PGE 2 signaling can impact colon cell proliferation survival, we examined how this pathway was affected in an resistant line. levels were significantly elevated oxaliplatin-resistant HT29 cells (OXR) compared naïve parental (PAR). This...

Serum glycosylated Wisteria floribunda agglutinin positive Mac-2 binding protein (WFA(+) -M2BP) levels are a non-invasive and reliable marker to assess the degree of liver fibrosis. We investigated use WFA(+) -M2BP predict mortality in patients with cirrhosis (LC).This retrospective study consisted 59 consecutive patients. Liver fibrosis was estimated by hyaluronic acid (HA), 7S fragment type IV collagen (7S collagen), aspartate aminotransferase-to-platelet ratio index (APRI) FIB-4 index....

Abstract Background The skin wound healing process is regulated by various cytokines, chemokines, and growth factors. Recent reports have demonstrated that spermine/spermidine (SPD) promote through urokinase-type plasminogen activator (uPA)/uPA receptor (uPAR) signaling in vitro. Here, we investigated whether the systemic topical administration of SPD would accelerate wound-repair vivo. Methods A repair model was established using C57BL/6 J mice. mixed with white petrolatum for...

FXR is a member of the nuclear receptor superfamily and bile acids are endogenous ligands FXR. activation has recently been reported to inhibit intestinal inflammation tumour development. This study aimed investigate whether novel agonist nelumal A, active compound plant Ligularia nelumbifolia, can prevent colitis colorectal carcinogenesis. In mouse model, dextran sodium sulfate-induced colonic mucosal ulcer grade in colon significantly reduced mice fed diets containing A. an...

// Tsuneyuki Miyazaki 1 , Yohei Shirakami 1, 2 Masaya Kubota Takayasu Ideta Takahiro Kochi Hiroyasu Sakai Takuji Tanaka 3 Hisataka Moriwaki Masahito Shimizu Department of Gastroenterology/Medicine, Gifu University Graduate School Medicine, Gifu, Japan Informative Clinical Tumor Pathology, Correspondence to: Shirakami, e-mail: ys2443@gifu-u.ac.jp Keywords: obesity, non-alcoholic steatohepatitis, liver carcinogenesis, sodium alginate, diabetes mellitus Received: November 24,...

Aberrant crypt foci (ACF) are the earliest morphologically identifiable lesions in colon that can be detected by high-definition chromoendoscopy with contrast dye spray. Although frequently associated synchronous adenomas, their role colorectal tumor development, particularly proximal colon, is still not clear. The goal of this study was to evaluate profile colon-adherent bacteria ACF and investigate relationship presence subtype polyps present throughout colon. Forty-five subjects...

Aim Obesity and its related metabolic abnormalities, including oxidative stress adipokine imbalance, are involved in liver carcinogenesis. The aim of the present study was to examine effects astaxanthin, a powerful biological antioxidant, on development diethylnitrosamine (DEN)‐induced tumorigenesis C57BL/KsJ‐ db/db ( ) obese mice. Methods Male mice were given single i.p. injection DEN (25 mg/kg bodyweight) at 2 weeks age, and, subsequently, from 4 they fed diet containing 200 p.p.m....

Transcatheter arterial chemoembolization (TACE) and transarterial infusion chemotherapy (TAI) are the main therapeutic strategies for treatment of advanced hepatocellular carcinoma (HCC). We conducted a randomized controlled trial to compare efficacy safety cisplatin miriplatin in TACE TAI.Patients with HCC indication or TAI were randomly assigned receive either (49 patients per group) between April 2010 May 2013. The primary end-point was effect (TE) 3 months after initial treatment,...

Although liver diseases, including non-alcoholic steatohepatitis, are associated with skeletal muscle atrophy, the mechanism behind their association has not been fully elucidated. In this study, effects of aging and steatohepatitis on muscle, interaction between were investigated using a diet-induced model in senescence-accelerated mice.A total four groups mice control fed either steatohepatitis-inducing or diet, livers muscles removed for examinations.In...

Background: Various vaccine adjuvants have been developed to eliminate HBV from patients with chronic infection. In addition, spermidine (SPD), a type of polyamine, has reported enhance the activity immune cells. present study, we investigated whether combination SPD and adjuvant enhances antigen-specific response vaccination. Methods: Wild-type HBV-transgenic (HBV-Tg) mice were vaccinated 2 or 3 times. was orally administered in drinking water. Cyclic guanosine monophosphate–AMP (cGAMP)...

// Takayasu Ideta 1 , Yohei Shirakami 1, 2 Masaya Ohnishi Akinori Maruta Koki Obara Tsuneyuki Miyazaki Takahiro Kochi Hiroyasu Sakai Hiroyuki Tomita 3 Takuji Tanaka 4 William S. Blaner 5 and Masahito Shimizu Department of Gastroenterology, Gifu University Graduate School Medicine, Gifu, Japan Informative Clinical Tumor Pathology, Division Municipal Hospital, Columbia University, New York, NY, USA Correspondence to: Shirakami, email: ys2443@gifu-u.ac.jp Keywords: retinoid, hepatocellular...

Prostaglandin E2 receptor EP4 is involved in inflammation and related tumorigenesis the colorectum. This study aimed to investigate chemopreventive ability of RQ-15986, a selective antagonist, colitis-related colorectal tumorigenesis. Male Kyoto APC delta rats, which have mutations, were treated with azoxymethane dextran sulfate sodium subsequently administered RQ-15986 for eight weeks. At end experiment, development tumor was significantly inhibited RQ-15986-treated group. The cell...

Stromal cells play a central role in promoting the progression of colorectal cancer. Here, we analyze molecular changes within epithelial and stromal compartments dysplastic aberrant crypt foci (ACF) formed ascending colon, where rapidly developing interval cancers occur. We found strong activation numerous neutrophil/monocyte chemokines, consistent with localized inflammation. The data also indicated decrease interferon signaling cell-based immunity. immune checkpoint T-cell exhaustion gene...

Obesity and related metabolic disorders, including chronic inflammation enhanced oxidative stress, are closely associated with the development progression of colorectal cancer. Previous epidemiological studies have demonstrated that increased serum uric acid is risk for various types cancer, colon This study examined effects a xanthine oxidase inhibitor allopurinol, widely used as lowering medicine, on tumorigenesis in obese mice. Male C57BL/KsJ-db/db mice were injected azoxymethane (15...