A5051910005- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Nutrition and Health in Aging
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Treatments and Studies
- Alcohol Consumption and Health Effects
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Organ Transplantation Techniques and Outcomes
- Diet, Metabolism, and Disease
- Helicobacter pylori-related gastroenterology studies
- Hepatitis C virus research
- Inflammatory mediators and NSAID effects
- Drug-Induced Hepatotoxicity and Protection
- Lung Cancer Treatments and Mutations
- COVID-19 and Mental Health
- Lymphoma Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Clinical Nutrition and Gastroenterology
- Neurological and metabolic disorders
- Eicosanoids and Hypertension Pharmacology
- HIV/AIDS drug development and treatment
- Lipid metabolism and disorders
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Biliary and Gastrointestinal Fistulas
Gifu University
1999-2025
Gifu University Hospital
2020-2025
Sapporo Kosei General Hospital
2020-2022
Sendai Kousei Hospital
2019-2020
Yamanashi Prefectural Central Hospital
1966
This cross-sectional study examined the prevalence and characteristics of steatotic liver disease (SLD) based on a recently introduced nomenclature in Japanese health checkup population. SLD was evaluated using ultrasonography, participants were categorized into metabolic dysfunction-associated (MASLD), dysfunction alcohol associated (MetALD), alcohol-associated/related (ALD), cryptogenic groups. The subclasses assessed, subgroup analyses conducted for non-obese (body mass index [BMI] ≤ 25...
This study aimed to investigate the usefulness of psoas muscle index (PMI) as an independent predictor survival after systemic targeted therapy initiation in patients with hepatocellular carcinoma (HCC). In total, 214 HCC who underwent at Gifu University Hospital were enrolled. The correlation between PMI and skeletal (SMI) was assessed using Pearson's coefficient (PCC). Cox proportional hazards model employed determine whether PMI, along α-fetoprotein (AFP) level ALBI score, influenced...
This study aimed to investigate the prevalence and prognostic impact of cachexia in patients with unresectable hepatocellular carcinoma (HCC) receiving systemic targeted therapy. single-center retrospective included HCC who underwent Cachexia was defined using novel criteria proposed 2023. The evaluated Cox proportional hazards model. Of 200 (160 males [80%]; median age, 73 years), identified 70 associated higher des-gamma-carboxy prothrombin levels, extrahepatic spread. Patients had...
The Global Leadership Initiative on Malnutrition (GLIM) criteria, a newly developed global consensus around core diagnostic criteria for malnutrition, needs validation studies use in daily clinical settings. This study aimed to determine whether the GLIM could predict sarcopenia and mortality patients with chronic liver disease (CLD).We retrospectively reviewed 858 CLD who were treated at our hospital between March 2013 December 2019. Sarcopenia was diagnosed based proposed by Japan Society...
Nonalcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated (MAFLD) are global concerns. The aim of this study was to reveal the relationship between body composition NAFLD MAFLD in male young adults.We recruited 335 graduate students from Gifu University who underwent a health checkup April 2022. diagnosis based on data ultrasonography. Muscle fat mass were measured using bioelectrical impedance analysis demonstrated as skeletal muscle index (FMI), respectively. We...
Rapid skeletal muscle loss adversely affects the clinical outcomes of liver cirrhosis. However, relationships between annual changes in area (ΔSMA/year) and etiology cirrhosis, factors associated with loss, risk mortality remains unclear.
The aim of this study was to investigate whether rapid depletions fat mass and skeletal muscle predict mortality in hepatocellular carcinoma (HCC) patients treated with sorafenib. This retrospective evaluated 61 HCC patients. cross-sectional areas visceral subcutaneous were measured by computed tomography, from which the index (VFMI), (SFMI), (L3SMI) obtained. relative changes these indices per 120 days (ΔVFMI, ΔSFMI, ΔL3SMI) before after sorafenib treatment calculated each patient. Patients...
Abstract Aim Nutritional counseling improves malnutrition, which determines the prognosis of patients with chronic liver disease. In this study, we investigated effects nutritional on mortality and risk overt hepatic encephalopathy (HE) in alcohol‐associated Methods retrospective cohort included 211 disease who visited Gifu University Hospital between August 2008 June 2023. Patients were classified into two groups according to frequency by a registered dietitian. The primary outcomes...
The application of indices in the context metabolic dysfunction-associated steatotic liver disease (MASLD) remains unexplored. We aimed to validate ability alanine aminotransferase (ALT), fatty index (FLI), and hepatic steatosis (HSI) identify MASLD during health checkups.
Abstract This study aimed to reveal the relationship between eating behavior and nonalcoholic fatty liver disease (NAFLD)/metabolic dysfunction-associated steatotic (MASLD) in young adults suggest a questionnaire for assessment. We included 322 male graduate students at Gifu University. Diagnoses of NAFLD MASLD were based on presence hepatic steatosis ultrasonography. Eating was assessed using (EBQ) recommended by Japan Society Study Obesity. behaviors associated with logistic regression,...
Cholangiocarcinoma-associated mortality has been increasing over the past decade. The sodium-glucose cotransporter 2 inhibitor, canagliflozin, demonstrated anti-tumor effects against several types of cancers; however, studies examining its potential impact on cholangiocarcinoma are lacking. This study investigated canagliflozin and nicotinamide adenine dinucleotide (NAD)+ salvage pathway activation sirtuin 1 tumor growth. We evaluated cell proliferation gene expression in lines analyzed...
Abstract This study aimed to evaluate whether the subjective global assessment (SGA) could effectively predict energy malnutrition, as assessed by indirect calorimetry, and mortality in hospitalized patients with cirrhosis. Energy malnutrition was defined a nonprotein respiratory quotient (npRQ) < 0.85 using an calorimetry. The usefulness of SGA identifying predicting logistic regression Cox proportional hazards models, respectively. Out 230 analyzed, 43% were found have malnutrition....
Rapid turnover proteins (RTPs), including retinol-binding protein (RBP), prealbumin, and transferrin, are useful in evaluating dynamic nutritional status. This study aimed to investigate the relationship between serum RTP levels mortality patients with chronic liver disease (CLD). We evaluated 341 CLD admitted October 2011 December 2021. Those RBP below 2.7 mg/dL for males 1.9 females were included low group. Factors associated using Cox proportional hazard regression logistic models. The...
Covert hepatic encephalopathy (CHE) leads to devastating outcomes in patients with cirrhosis. This study aims elucidate the current management and future perspectives of CHE Japan. A questionnaire-based cross-sectional was conducted among physicians involved managing cirrhosis The primary aim real-world CHE, including testing treatment. Factors influencing implementation were analyzed using a logistic regression model. Limitations for improving also evaluated. Of 511 surveyed, 93.9%...
Background/Objective: Recently, there has been an increasing need to implement the diagnosis of presence covert hepatic encephalopathy (CHE) in patients with cirrhosis. The aim this study was identify novel factors associated CHE clinical practice. Methods: This retrospective enrolled a total 402 cirrhosis at 17 institutions. Stroop test performed diagnose each center. Results: comprised 233 males and 169 females, median age 69 (IQR, 61–75) years. albumin 25(OH)D3 levels were 3.9 (3.5–4.3)...
Abstract Aim Cachexia is a systemic response syndrome characterized by disabling wasting during disease progression. This study aimed to elucidate factors associated with cachexia in patients cirrhosis and examine the impact of on patient survival. Methods multicenter retrospective cohort included admitted two distinct institutes Japan. was diagnosed according criteria proposed Asian Working Group for Cachexia. Factors prognostic were assessed using logistic regression Cox proportional...
Sarcopenia, the loss of skeletal muscle mass, impairs prognosis patients with liver cirrhosis. The aim this study was to investigate effect loop diuretics, which are frequently used treat hepatic edema/ascites, on depletion and in cirrhosis.This retrospective evaluated 226 cross-sectional area at level third lumbar vertebra measured using computed tomography. relative change per year (ΔSMA) calculated, association between ΔSMA therapeutic dosage diuretics examined.The inversely correlated by...
Abstract Aim Minimal hepatic encephalopathy (MHE) is associated with poor outcomes and the development of overt (OHE) in patients liver cirrhosis (LC). Zinc plays a key role detoxification ammonia, risk factor encephalopathy. This study aimed to investigate whether zinc deficiency predicts OHE occurrence mortality LC MHE. Method retrospective included 100 MHE was diagnosed using computer‐aided neuropsychiatric test. Predictors were analyzed Fine–Gray competing regression model. Cox...
This study aimed to assess the effects of lenvatinib (LEN) or sorafenib (SOR) treatment for hepatocellular carcinoma (HCC) on body composition and changes in survival. enrolled 77 HCC patients. Skeletal muscle index (SMI), subcutaneous visceral adipose tissue indices (SATI VATI), AFP, PIVKA-II, ALBI scores were analyzed at time LEN/SOR introduction, three months after discontinuation, last observational time. The differences between chronological these values using a paired t-test. Cox...
Acute kidney injury (AKI) is a serious complication of cirrhosis. This study analyzed the prognostic effect AKI in patients with cirrhosis and its risk factors, particularly relation to amino acid imbalance.
More effective treatments for hepatitis viral infections have led to a reduction in the incidence of liver cirrhosis. A high-fat diet can lead chronic and fibrosis, but effects lipid intake on disease status, including C virus alcohol, after elimination cause are unclear. To investigate effects, we used rat cirrhosis model this study. Male Wistar rats were administered carbon tetrachloride 5 weeks. At 12 weeks age, one group was sacrificed. The remaining divided into four groups according...
This study aimed to investigate the differences in mental health during COVID-19, specifically among second-, third-, and fourth-year Japanese university students (n = 2,157; n 2,000; 2,284; respectively). A one-way MANOVA was conducted assess association between year of enrollment (academic years 2020, 2021, 2022) each eight subscales counseling Center Assessment Psychological Symptoms-Japanese. For second-year students, depression generalized anxiety mean scores were higher 2021 than those...
This study aimed to evaluate chronological changes in skeletal muscle index (SMI), subcutaneous and visceral adipose tissue indices (SATI VATI), AFP, PIVKA-II, ALBI scores during atezolizumab plus bevacizumab (AB) or lenvatinib (LEN) treatment for hepatocellular carcinoma (HCC) the effect of these on survival. A total 94 patients with HCC (37 were AB 57 LEN) enrolled. SMI, SATI, VATI, analyzed at time introduction (Intro), 3 months after (3M), drug discontinuation (End), last observational...
Colorectal cancer represents one of the most serious complications inflammatory bowel disease. The NLRP3 inflammasome plays a pivotal role in onset and progression disease is also implicated colorectal cancer. This study aimed to investigate whether deficiency or glyburide, sulfonylurea used for diabetes management known as an inhibitor, could suppress colitis its related tumorigenesis. Mice were divided into three groups: control group, glyburide NLRP3-deficient group. We investigated acute...