A5027529203- Health Systems, Economic Evaluations, Quality of Life
- Cancer Treatment and Pharmacology
- Breast Cancer Treatment Studies
- Advanced Breast Cancer Therapies
- HER2/EGFR in Cancer Research
- Advanced Causal Inference Techniques
- Liver Disease Diagnosis and Treatment
- Statistical Methods in Clinical Trials
- Economic and Financial Impacts of Cancer
- Cancer survivorship and care
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Dementia and Cognitive Impairment Research
- Birth, Development, and Health
- Alcohol Consumption and Health Effects
- Child Nutrition and Water Access
- Cancer Genomics and Diagnostics
- Diabetes Treatment and Management
- Hepatocellular Carcinoma Treatment and Prognosis
- Aging and Gerontology Research
- Cancer-related cognitive impairment studies
- Diet, Metabolism, and Disease
- Potassium and Related Disorders
- Atrial Fibrillation Management and Outcomes
The University of Tokyo
2016-2025
Toko University
2023
University of Tokyo Health Sciences
2021-2022
Japan Breast Cancer Research Group
2021
University of Tokyo Hospital
2019
National Cancer Center Hospital East
2019
The Cancer Institute Hospital
2019
Okayama University Hospital
2019
Aichi Cancer Center
2019
Japanese Foundation For Cancer Research
2019
Abstract Background Improving patients' oral hygiene is an option for preventing postoperative pneumonia that may be caused by aspiration of and pharyngeal secretions. Whether preoperative care a dentist can decrease complications remains controversial. A retrospective cohort study was undertaken to assess the association between among patients who underwent major cancer surgery. Methods The nationwide administrative claims database in Japan analysed. Patients were identified resection head...
The objective of this randomized phase II trial was to evaluate efficacy and safety the therapeutic sequence regorafenib followed by cetuximab, compared with cetuximab regorafenib, as current standard for metastatic colorectal cancer patients.
Abstract Background and Aims Small hypovascular hepatocellular carcinoma ( HCC ) ≤2 cm is biologically less aggressive than hypervascular one, however, the optimal treatment still undetermined. The efficacy of surgical resection SR ), radiofrequency ablation RFA percutaneous ethanol injection PEI was evaluated. Methods 853 , 176; 491; 186) patients were enrolled who met Child‐Pugh A/B, single pathologically proven, available tumour differentiation absence macrovascular invasion extrahepatic...
Maternal nutrition during pregnancy is crucial to ensure positive outcomes for both the mother and newborn. Despite its importance, maternal nutritional status remains poor, particularly in low- middle-income countries, where social, cultural economic factors play a pivotal role. This study assessed adequacy of energy dietary nutrient intake among Sri Lankan pregnant women compared their reference intakes. was part Lanka Mother Newborn Growth study, nationwide prospective cohort 2000 women....
Abstract Electronic patient-reported outcome (ePRO) monitoring for patients undergoing cancer chemotherapy may provide qualified and early detection of adverse events or disease-related symptoms, leading to improved patient care. The aim this study is examine whether addition ePRO routine medical care contributes overall survival quality life chemotherapy. Patients with unresectable advanced cancers metastatic/recurrent solid tumors receiving systemic will be randomized an group a usual...
This study aimed to estimate the individualized effect of weight change since age 20 on development metabolic dysfunction-associated steatotic liver disease (MASLD) in Japanese non-obese individuals. We also assessed clinical characteristics high-risk individuals with gain. retrospective cohort included who underwent health examinations at St. Luke's International Hospital between 2008 and 2018. developed a counterfactual prediction model using logistic regression predict risk MASLD onset...
Abstract Aim Cachexia is a systemic response syndrome characterized by disabling wasting during disease progression. This study aimed to elucidate factors associated with cachexia in patients cirrhosis and examine the impact of on patient survival. Methods multicenter retrospective cohort included admitted two distinct institutes Japan. was diagnosed according criteria proposed Asian Working Group for Cachexia. Factors prognostic were assessed using logistic regression Cox proportional...
INTRODUCTION: Most studies predicting survival after resection, transarterial chemoembolization (TACE), and ablation analyzed diameter number of hepatocellular carcinomas (HCCs) as dichotomous variables, resulting in an underestimation risk variation. We aimed to develop validate a new prognostic model for patients with HCC using largest HCCs continuous variables. METHODS: The was developed data from undergoing TACE, 645 Japanese institutions. results were shown balanced the inverse...
To develop direct and indirect (response) mapping algorithms from the European Organization for Research Treatment of Cancer Quality Life Questionnaire Core 30 (EORTC QLQ-C30) Functional Assessment Therapy General (FACT-G) onto EQ-5D-5L index.We conducted QOL-MAC study where EQ-5D-5L, EORTC QLQ-C30, FACT-G were cross-sectionally evaluated in patients receiving drug treatment solid tumors Japan. We developed using 7 regression methods. Direct was based on Japanese value set. predictive...
The aim of this study was to investigate the impact adverse events (AEs) on health utility and health-related quality life (HRQOL) in patients with metastatic breast cancer undergoing first-line chemotherapy. We analyzed data from SELECT BC study, a multicenter, open-label, randomized, phase III conducted Japan, which compared S-1 taxane therapies. Heath HRQOL were assessed using EQ-5D-3L European Organization for Research Treatment Cancer Quality Life Questionnaire Core 30 (EORTC QLQ-C30)...
Abstract Purpose To establish minimal important differences (MIDs) for the European Organisation Research and Treatment Cancer Quality of life Questionnaire core 30 (EORTC QLQ-C30) in patients with metastatic breast cancer. Methods The dataset was obtained from SELECT BC-CONFIRM randomized clinical trial. Anchors (transition items) clinicians (performance status) were used anchor-based methods. through 6 months after starting treatment this analysis. Correlation coefficients anchor change...
The goal of chemotherapy for metastatic breast cancer (MBC) is to prolong survival and maintain health-related quality life. This study aimed evaluate long-term health status patients with MBC who participated in the phase III randomized SELECT BC trial. In trial, were randomly allocated S-1 or taxane (paclitaxel docetaxel) arm. Health was assessed by EQ-5D at pre-treatment, 3 6 months after randomization, every thereafter extent possible. Least square mean scores compare index values...
To assess the risk of urinary tract infection (UTI) occurrence associated with sodium-glucose cotransporter-2 (SGLT2) inhibitor use relative to biguanide in diabetes a population-based cohort study using target trial emulation framework.Using Japanese nationwide administrative claims database, we constructed patients aged ≥40 years who were dispensed SGLT2 inhibitors, dipeptidyl peptidase-4 (DPP-4) inhibitors or biguanides between April 2014 and March 2015. For computational ease, randomly...
Modified Poisson regression, which estimates the regression parameters in log-binomial model using quasi-likelihood estimating equation and robust variance, is a useful tool for adjusted risk prevalence ratio binary outcome analysis. Although several goodness-of-fit tests have been developed other regressions, few are available modified regression. In this study, we proposed including Hosmer-Lemeshow test with empirical Tsiatis test, normalized Pearson chi-square binomial variance residual...
INTRODUCTION: We aimed to investigate the effect of recent short-term weight gain on incidence nonalcoholic fatty liver disease (NAFLD) in nonobese (body mass index < 25 kg/m 2 ) participants. METHODS: This retrospective cohort study included individuals who participated an annual health checkup between 2008 and 2018 Tokyo, Japan. estimated multivariable adjusted hazard ratio for development NAFLD diagnosed via ultrasound after a 3-kg unit measured at 2-year landmark time point...
Although several noninvasive predictive markers for fatty liver and metabolic have been used prediction, whether such can also predict metabolic-associated disease (MAFLD) remains unclear. We aimed to examine the ability of existing or MAFLD.Participants in a high-volume center Tokyo were classified into groups with without MAFLD, based on presence abnormalities diagnosed through abdominal ultrasonography, between 2008 2018. The diagnostic abilities three markers: index (FLI), hepatic...
ObjectiveThis study was performed to compare health-related quality of life (HRQOL) gemcitabine plus S-1 (GS), alone and as first-line chemotherapy for locally advanced or metastatic pancreatic cancer in the GEST (Gemcitabine TS-1 Trial) assess impacts adverse events tumour response on HRQOL.MethodsPatients were randomly assigned receive (1000 mg/m2 weekly 3 4 weeks), (80, 100 120 mg/day twice daily 6 weeks) GS (gemcitabine at 1000 60, 80 2 weeks). HRQOL assessed using EuroQoL-5D (EQ-5D)...
Abstract Relaxation times and morphological information are fundamental magnetic resonance imaging-derived metrics of the human brain that reflect status underlying tissue. Magnetic fingerprinting (MRF) enables simultaneous acquisition T1 T2 maps inherently aligned to anatomy, allowing whole-brain relaxometry morphometry in a single scan. In this study, we revealed feasibility 3D MRF for structure-wise relaxometry. Comprehensive test–retest scan analyses using five 1.5-T three 3.0-T systems...
Perinatal cohort studies with a prospective longitudinal design are critical for determining the effects of early-life exposures on offspring's health outcomes. The Sri Lanka Mother and Newborn Growth study aims to investigate impact maternal nutritional psychosocial factors newborns' birth weight in Lankan context. This paper presents methodology participant recruitment, follow-ups, an overview measurements, planned data analyses. included nationally representative sample pregnant women...