A5082501797- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- MRI in cancer diagnosis
- Cardiac Imaging and Diagnostics
- Advanced NMR Techniques and Applications
- Atomic and Subatomic Physics Research
- Functional Brain Connectivity Studies
- Sparse and Compressive Sensing Techniques
- Radiomics and Machine Learning in Medical Imaging
- Electron Spin Resonance Studies
- Apelin-related biomedical research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cardiovascular Function and Risk Factors
- Ultrasound Imaging and Elastography
- Mitochondrial Function and Pathology
- Infrared Thermography in Medicine
- Cardiac Ischemia and Reperfusion
- Nitric Oxide and Endothelin Effects
- Ultrasound and Hyperthermia Applications
- RNA regulation and disease
- Single-cell and spatial transcriptomics
- Blind Source Separation Techniques
- Lanthanide and Transition Metal Complexes
- Fetal and Pediatric Neurological Disorders
Fondazione Stella Maris
2018-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2023
University of Cambridge
2012-2019
Addenbrooke's Hospital
2012-2019
Cambridge University Hospitals NHS Foundation Trust
2019
Cancer Research UK
2019
Siemens Healthcare (Germany)
2019
Bridge University
2019
Cancer Research UK Cambridge Center
2019
General Electric (Spain)
2019
Elabela/toddler (ELA) is a critical cardiac developmental peptide that acts through the G-protein-coupled apelin receptor, despite lack of sequence similarity to established ligand apelin. Our aim was investigate receptor pharmacology, expression pattern, and in vivo function ELA peptides adult cardiovascular system, seek evidence for alteration pulmonary arterial hypertension (PAH) which signaling downregulated, demonstrate attenuation PAH severity with exogenous administration rat model.In...
MR fingerprinting (MRF) can be used for quantitative estimation of physical parameters in MRI. Here, we extend the method to incorporate B1 estimation.The acquisition is based on steady state free precession with a Cartesian trajectory. To increase sensitivity profile, abrupt changes flip angle were introduced sequence. Slice profile and effects included dictionary results from two- three-dimensional (3D) acquisitions compared. Acceleration was demonstrated using retrospective undersampling...
Monoamine oxidase (MAO) inhibitors ameliorate contractile function in diabetic animals, but the mechanisms remain unknown. Equally elusive is interplay between cardiomyocyte alterations induced by hyperglycemia and accompanying inflammation. Here we show that exposure of primary cardiomyocytes to high glucose pro-inflammatory stimuli leads MAO-dependent increase reactive oxygen species causes permeability transition pore opening mitochondrial dysfunction. These events occur upstream...
Abstract Novel methods for quantitative, transient-state multiparametric imaging are increasingly being demonstrated assessment of disease and treatment efficacy. Here, we build on these by assessing the most common Non-Cartesian readout trajectories (2D/3D radials spirals), demonstrating efficient anti-aliasing with a k- space view-sharing technique, proposing novel parameter inference neural networks that incorporate estimation proton density. Our results show good agreement gold standard...
Background:N-methyl-d-aspartate receptor (NMDAR) dysfunction is thought to contribute the pathophysiology of schizophrenia. Accordingly, NMDAR antagonists such as phencyclidine (PCP) are used widely in experimental animals model cognitive impairment associated with this disorder. However, it unclear whether PCP disrupts structural integrity brain areas relevant profile
Mitochondrial complex I, the primary entry point for electrons into mitochondrial respiratory chain, is both critical aerobic respiration and a major source of reactive oxygen species. In heart, chronic dysfunction driving cardiomyopathy frequently associated with decreased I activity, from genetic environmental causes. To examine functional relationship between disruption cardiac we used an established mouse model mild inhibition through heart-specific Ndufs4 gene ablation. Heart-specific...
Recently it has been shown that the mitochondria-targeted S-nitrosothiol MitoSNO protects against acute ischaemia/reperfusion (IR) injury by inhibiting reactivation of mitochondrial complex I in first minutes reperfusion ischaemic tissue, thereby preventing free radical formation underlies IR injury. However, remains unclear how this transient inhibition I-mediated radicals at affects long-term recovery heart following Here we determined whether protection prevented subsequent development...
Purpose To obtain a fast and robust fat‐water separation with simultaneous estimation of water T 1 , fat fraction maps. Methods We modified an MR fingerprinting (MRF) framework to use single dictionary combination dictionary. A variable TE acquisition pattern maximum = 4.8 ms was used increase the fat–water separability. Radiofrequency (RF) spoiling reduce size by reducing 2 sensitivity. The technique compared both in vitro vivo MRF method that incorporated 3‐point Dixon (DIXON MRF), as well...
To investigate a computationally efficient method for optimizing the Cramér-Rao Lower Bound (CRLB) of quantitative sequences without using approximations or an analytical expression signal.
Background and Purpose Apelin is an endogenous vasodilatory inotropic peptide that down‐regulated in human pulmonary arterial hypertension, although the density of apelin receptor not significantly attenuated. We hypothesised a G protein‐biased analogue MM07, which more stable than peptide, may be beneficial this condition with advantage reduced β‐arrestin‐mediated internalisation chronic use. Experimental Approach Male Sprague–Dawley rats received either monocrotaline to induce hypertension...
To obtain three-dimensional (3D), quantitative and motion-robust imaging with magnetic resonance fingerprinting (MRF).Our acquisition is based on a 3D spiral projection k-space scheme. We compared different orderings of trajectory interleaves in terms rigid motion-correction robustness. In all tested orderings, we considered the whole dataset as sum 56 segments 7-s duration, acquired sequentially same flip angle schedule. performed separate image reconstruction for each segment, producing...
Stimulation of the nitric oxide (NO)--soluble guanylate (sGC)--protein kinase G (PKG) pathway confers protection against acute ischaemia/reperfusion injury, but more chronic effects in reducing post-myocardial infarction (MI) heart failure are less defined. The aim this study was to not only determine whether sGC stimulator riociguat reduces infarct size also it protects development post-MI failure.Mice were subjected 30 min ischaemia via ligation left main coronary artery induce MI and...
Magnetic resonance fingerprinting (MRF) is highly promising as a quantitative MRI technique due to its accuracy, robustness, and efficiency. Previous studies have found high repeatability reproducibility of 2D MRF acquisitions in the brain. Here, we extended our investigations 3D covering whole brain using spiral projection k-space trajectories. Our travelling head study acquired test/retest data from brains 12 healthy volunteers 8 systems (3 at 3 T 5 1.5 T, all single vendor), design not...
Advanced MRI-based biomarkers offer comprehensive and quantitative information for the evaluation characterization of brain tumors. In this study, we report initial clinical experience in routine glioma imaging with a novel, fully 3D multiparametric transient-state (QTI) method tissue based on T1 T2 values.To demonstrate viability proposed QTI technique, nine patients (grade II-IV), variety disease states treatment histories, were included study. First, investigated feasibility (6:25 min...
HD is a progressive genetic neurological disorder, characterized by motor as well cognitive impairments. The gene carrying the mutation causing Huntington's disease (HD) not brain specific, and there increasing evidence for peripheral, we
Purpose To compare the bias and inherent reliability of quantitative (T 1 T 2 ) imaging metrics generated from magnetic resonance fingerprinting (MRF) technique using ISMRM/NIST system phantom in an international multicenter setting. Method MRI provides standard reference relaxation values (vendor‐provided) for each 14 vials arrays. MRF‐SSFP scans repeated over 30 days on GE 1.5 3.0 scanners at three collaborative centers. MRF estimated 1, averaged were compared with vendor‐provided...
Abstract Magnetic resonance imaging of the pancreas is increasingly used as an important diagnostic modality for characterisation pancreatic lesions. Pancreatic MRI protocols are mostly qualitative due to time constraints and motion sensitivity. MR Fingerprinting innovative acquisition technique that provides data quantitative parameter maps from a single free‐breathing with potential reduce exam times. This work investigates feasibility MRF mapping in presence free-breathing exam. Sixteen...
Magnetic resonance imaging (MRI) has evolved into an outstandingly versatile diagnostic modality, as it the ability to non-invasively produce detailed information on a tissue's structure and function. Complementary data is normally obtained in separate measurements, either contrast-weighted images, which are fast simple acquire, or quantitative parametric maps, offer absolute quantification of underlying biophysical effects, such relaxation times flow. Here, we demonstrate how acquire...
Abstract Three‐dimensional (3D) Magnetic resonance fingerprinting (MRF) permits whole‐brain volumetric quantification of T1 and T2 relaxation values, potentially replacing conventional T1‐weighted structural imaging for common brain analysis. The aim this study was to evaluate the repeatability reproducibility 3D MRF in evaluating cortical thickness subcortical analysis healthy volunteers using images as a reference standard. Scan‐rescan tests both fast spoiled gradient recalled echo (FSPGR)...
Abstract Magnetic resonance fingerprinting (MRF) is a rapidly developing fast quantitative mapping technique able to produce multiple property maps with reduced sensitivity motion. MRF has shown promise in improving the diagnosis of clinically significant prostate cancer but requires further validation as part multiparametric (mp) MRI protocol. mpMRI protocol mandates inclusion dynamic contrast enhanced (DCE) imaging, known for its T 1 shortening effect. could be used measure both pre- and...
The disruption of the blood–brain barrier (BBB) is a key and early feature in pathogenesis demyelinating multiple sclerosis (MS) lesions has been neuropathologically demonstrated both active chronic plaques. local overt BBB acute captured as signal hyperintensity post-contrast T1-weighted images because contrast-related shortening T1 relaxation time. On contrary, subtle not visible at conventional radiological evaluation but it might be clinical relevance. Indeed, persistent, leakage linked...
Increasingly, evidence from studies in both animal models and patients suggests that cardiovascular dysfunction is important HD. Previous measuring function of the left ventricle (LV) R6/2 model have found a clear cardiac abnormality, albeit with preserved LV systolic function. It was hypothesized an impairment RV might play role this condition via mechanisms ventricular interdependence.To investigate mouse Huntington's disease (HD).Cardiac cine-magnetic resonance imaging (MRI) used to...