A5024016547- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- MRI in cancer diagnosis
- Bone and Joint Diseases
- Fetal and Pediatric Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Cerebrovascular and Carotid Artery Diseases
- Cerebrospinal fluid and hydrocephalus
- Multiple Sclerosis Research Studies
- Neurological disorders and treatments
- Intracranial Aneurysms: Treatment and Complications
- Moyamoya disease diagnosis and treatment
- Medical Imaging Techniques and Applications
- Vascular Malformations Diagnosis and Treatment
- Cervical and Thoracic Myelopathy
- Medical Imaging and Analysis
- Spinal Dysraphism and Malformations
- Vascular Malformations and Hemangiomas
- Atomic and Subatomic Physics Research
- Ultrasound and Hyperthermia Applications
- Radiomics and Machine Learning in Medical Imaging
- Endometriosis Research and Treatment
- Brain Tumor Detection and Classification
- Uterine Myomas and Treatments
Toho University
2007-2025
Toho University Omori Medical Center
2009-2025
Kawasaki Medical School
2025
Juntendo University
2015-2024
Nagoya Institute of Technology
2022-2023
Juntendo University Hospital
2010-2022
Nagoya University
2003-2022
University of Yamanashi Hospital
2000-2019
Toshiba (Japan)
2017
University of Yamanashi
2003-2017
The glymphatic system is a whole-brain perivascular network, which promotes CSF/interstitial fluid exchange. Alterations to this may play pivotal role in amyloid β (Aβ) accumulation. However, its involvement Alzheimer disease (AD) pathogenesis not fully understood. Here, we investigated the changes noninvasive MRI measurements related network patients with mild cognitive impairment (MCI) and AD. Additionally, explored associations of measures neuropsychological score, PET standardized uptake...
The relationship between fibroids and infertility remains an unsolved question, management of intramural is controversial. During the implantation phase, uterine peristalsis dramatically reduced, which thought to facilitate embryo implantation. Our aims were evaluate (i) occurrence frequency in infertile women with (ii) whether presence decreases pregnancy rate. Ninety-five patients examined using magnetic resonance imaging (MRI). Inclusion criteria as follows: fibroids, excluding submucosal...
Magnetization transfer (MT) imaging has been widely used for estimating myelin content in the brain. Recently, two other approaches, namely simultaneous tissue relaxometry of R1 and R2 relaxation rates proton density (SyMRI) ratio T1-weighted to T2-weighted images (T1w/T2w ratio), were also proposed as methods measuring myelin. SyMRI MT have reported correlate well with actual by histology. However, T1w/T2w ratio, such evidence is limited. In 20 healthy adults, we examined correlation...
<h3>BACKGROUND AND PURPOSE:</h3> Synthetic MR imaging enables the creation of various contrast-weighted images including double inversion recovery and phase-sensitive from a single quantification scan. Here, we assessed whether synthetic is suitable for detecting MS plaques. <h3>MATERIALS METHODS:</h3> Quantitative conventional data on 12 patients with were retrospectively analyzed. T2-weighted, FLAIR, recovery, produced after T1 T2 values proton density. Double optimized each patient by...
Mapping gray matter (GM) pathology in Parkinson's disease (PD) with conventional MRI is challenging, and the need for more sensitive brain imaging techniques essential to facilitate early diagnosis assessment of severity. GM microstructure was assessed GM-based spatial statistics applied diffusion kurtosis (DKI) neurite orientation dispersion (NODDI) 30 participants PD 28 age- gender-matched controls. These were compared currently used methods such as tensor (DTI), voxel-based morphometry...
Objectives The aim of this study was to evaluate the linearity, bias, intrascanner repeatability, and interscanner reproducibility quantitative values derived from a multidynamic multiecho (MDME) sequence for rapid simultaneous relaxometry. Materials Methods NIST/ISMRM (National Institute Standards Technology/International Society Magnetic Resonance in Medicine) phantom, containing spheres with standardized T1 T2 relaxation times proton density (PD), 10 healthy volunteers, were scanned on...
Spinal cord lesions detected on MRI hold important diagnostic and prognostic value for multiple sclerosis. Previous attempts to correlate lesion burden with clinical status have had limited success, however, suggesting that location may be a contributor. Our aim was explore the spatial distribution of sclerosis in cervical spinal cord, respect status. We included 642 suspected or confirmed patients (31 clinically isolated syndrome, 416 relapsing-remitting, 84 secondary progressive, 73...
<h3>BACKGROUND AND PURPOSE:</h3> Synthetic FLAIR images are of lower quality than conventional images. Here, we aimed to improve the synthetic image using deep learning with pixel-by-pixel translation through conditional generative adversarial network training. <h3>MATERIALS METHODS:</h3> Forty patients MS were prospectively included and scanned (3T) acquire MR imaging created SyMRI software. Acquired data divided into 30 training 10 test datasets. A was trained generate improved from raw as...
OBJECTIVE We prospectively investigated the predictive value of diffusion tensor tractography for motor functional outcome in a case series patients with intracerebral hemorrhage. METHODS Diffusion was performed 17 hemorrhage (putamen, nine patients; thalamus, seven combined, one patient) within 5 days after onset. Mean fractional anisotropy (FA) and apparent coefficient (ADC) values along corticospinal tracts at level hematoma were measured bilaterally, ratios (hematoma side/contralateral...
<h3>BACKGROUND AND PURPOSE:</h3> In PD, the neurodegenerative process begins in brain stem and extends to limbic system finally into cerebral cortex. We used diffusion tensor tractography investigate FA of cingulate fiber tracts patients with PD without dementia. <h3>MATERIALS METHODS:</h3> Fifteen 15 PDD, age-matched healthy controls underwent imaging a 3T MR imager. Diffusion images anterior posterior were generated. Mean diffusivity measured along tracts. One-way ANOVA Scheffé post hoc...
We investigated the relationship between white-matter alteration and cognitive status in Parkinson's disease (PD) with without dementia by using diffusion tensor imaging.Twenty PD patients, 20 PDD (Parkinson's dementia) patients age-matched healthy controls underwent imaging. The mean diffusivity fractional anisotropy (FA) map of each patient group were compared those control tract-based spatial statistics. Tractography images genu corpus callosum fibre tracts generated, FA measured.FA...
<h3>BACKGROUND AND PURPOSE:</h3> Blood flow in an intracranial stent cannot be visualized with 3D time-of-flight MR angiography owing to magnetic susceptibility and radiofrequency shielding. As a novel follow-up tool after stent-assisted coil embolization, we applied MRA by using Silent Scan algorithm that contains ultrashort TE combined arterial spin-labeling technique (Silent MRA). The purpose of this study was determine whether could visualize placed the anterior circulation....
The posterior parietal cortex (PPC) features close anatomical and functional relationships with the prefrontal cortex. However, necessity of PPC in executive functions has been questioned. present study used stop-signal task to examine response inhibition, an function that inhibits prepotent tendency. brain activity resting-state connectivity were measured analyze a parcellation-based network was aimed at identifying candidate region essential for inhibition humans. intraparietal sulcus...
Previous methods for the quantification of brain tissue properties by magnetic resonance imaging were mainly based on two-dimensional acquisitions and thus limited to a relatively low resolution in slice direction compared three-dimensional (3D) acquisitions. The 3D-quantification using an interleaved Look–Locker acquisition sequence with T2 preparation pulse (3D-QALAS) may allow simultaneous relaxometry parameters high spatial resolution. To evaluate bias, linearity, day-to-day...
This study aimed to discriminate between neuroinflammation and neuronal degeneration in the white matter (WM) gray (GM) of patients with Parkinson’s disease (PD) using free-water (FW) imaging. Analysis tract-based spatial statistics (TBSS) 20 PD healthy individuals revealed changes FW imaging indices (i.e., reduced FW-corrected fractional anisotropy (FAT), increased mean, axial, radial diffusivities (MDT, ADT, RDT, respectively) volume somewhat more specific WM areas compared DTI indices....