A5001048945- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Multiple Sclerosis Research Studies
- Advanced NMR Techniques and Applications
- RNA regulation and disease
- Ultrasound and Hyperthermia Applications
- Bone and Joint Diseases
- Ultrasound Imaging and Elastography
- MRI in cancer diagnosis
- Functional Brain Connectivity Studies
- Systemic Lupus Erythematosus Research
- Medical Imaging and Analysis
- Neurogenesis and neuroplasticity mechanisms
- NMR spectroscopy and applications
- Spinal Cord Injury Research
- Peripheral Neuropathies and Disorders
- Cerebral Palsy and Movement Disorders
- Traumatic Brain Injury Research
- Cerebrovascular and Carotid Artery Diseases
- Electron Spin Resonance Studies
- Lysosomal Storage Disorders Research
- Spinal Dysraphism and Malformations
- Neuroinflammation and Neurodegeneration Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Acute Ischemic Stroke Management
University of British Columbia
2016-2025
International Collaboration On Repair Discoveries
2016-2025
University of British Columbia Hospital
2004-2021
Astronomy and Space
2021
Vancouver Biotech (Canada)
2021
Vancouver General Hospital
2012-2020
Parker Hannifin (United States)
2020
Vancouver Spine Surgery Institute
2020
Université Claude Bernard Lyon 1
2019
Centre National de la Recherche Scientifique
2019
Various magnetic resonance (MR) techniques are used to study the pathological evolution of demyelinating diseases, such as multiple sclerosis (MS). However, few studies have validated MR derived measurements with histopathology. Here, we determine correlation myelin water imaging, an measure content, quantitative histopathologic measures density. The multi-component T 2 distribution was determined from 25 formalin-fixed MS brain samples using a multi-echo relaxation experiment. fraction...
Abstract Purpose To investigate the correlation between water content (WC) and magnetization transfer ratio (MTR) in normal multiple sclerosis (MS) brain. The MTR has been proposed as a marker for myelin central nervous system tissue. However, changes WC due to inflammation edema may also affect MTR. Materials Methods Seven MS subjects with active disease seven age‐ gender‐matched controls were scanned using quantitative magnetic resonance techniques. WC, content, T 1 relaxation time,...
Abstract Myelin water imaging is a quantitative neuroimaging technique that provides the myelin fraction (MWF), metric highly specific to content, and intra-/extra-cellular T 2 (IET2), which related iron content. We coupled high-resolution data from 100 adults with gold-standard methodology create an optimized anatomical brain template accompanying MWF IET2 atlases. then used atlas characterize how content relates demographic factors. In most regions, followed quadratic pattern of increase...
Purpose Myelin water fraction is conventionally measured from the T 2 decay curve. Recently, a steady‐state approach entitled multicomponent‐driven equilibrium single pulse observation of 1 /T (mcDESPOT) was employed for myelin mapping. However, no direct comparison between established multiecho relaxation method and mcDESPOT has been performed. Methods Gradient spin echo (GRASE) acquired curve measurements were 10 healthy volunteers using 3T MRI. We compared fraction, transmit radio...
Abstract In a companion paper by Cohen-Adad et al . we introduce the spine generic quantitative MRI protocol that provides valuable metrics for assessing spinal cord macrostructural and microstructural integrity. This was used to acquire single subject dataset across 19 centers multi-subject 42 (for total of 260 participants), spanning three main manufacturers: GE, Philips Siemens. Both datasets are publicly available via git-annex. Data were analysed using Spinal Cord Toolbox produce...
Background: The pathological basis of diffusely abnormal white matter (DAWM) in multiple sclerosis (MS) has not been elucidated detail, but may be an important element disability and clinical progression. Methods: Fifty-three subjects with MS were examined T 1 , multi-echo 2 magnetization transfer (MT). Twenty-three samples formalin-fixed brain tissue subsequently stained for myelin phospholipids using luxol fast blue, axons Bielschowsky, immunohistochemically the proteins basic protein...
Background: Spinal cord involvement in multiple sclerosis (MS) is common and an important element disability. Previous studies demonstrated smaller cervical area at the C2 level MS compared to controls, a decrease over 12 months, most marked primary progressive (PPMS). A subset of subjects participating multicentre, double-blind, placebo-controlled clinical trial evaluating efficacy glatiramer acetate PPMS (PROMiSe trial) were followed for 2 years. Methods: 24 subjects, randomized placebo (...
Although multiple sclerosis (MS) lesions have been studied extensively using histology and magnetic resonance imaging (MRI), little is known about diffusely abnormal white matter (DAWM). Diffusely matter, regions with reduced mild MRI hyperintensity ill-defined boundaries, show myelin water fraction, decreased Luxol fast blue staining of phospholipids, relative preservation basic protein 2′,3′-cyclic-nucleotide 3′-phosphohydrolase. Because DAWM may be important in MS disability progression,...
Purpose To assess the reproducibility of myelin water fraction (MWF) and geometric mean T 2 (GMT ), which are in vivo markers pathological changes underlying disability progression diseases such as multiple sclerosis. Materials Methods Five healthy volunteers were scanned twice within 24 hours at six different sites using same manufacturer's 3T magnetic resonance (MR) system. distributions produced by fitting multiecho 3D data non‐negative least squares, with stimulated echo correction. MWF,...
We investigated the evolution of new multiple sclerosis (MS) lesions over time using frequency shifts magnetic resonance (MR) signal.Twenty patients with relapsing-remitting MS were serially scanned for 6 months at 1-month intervals. Maps MR acquired susceptibility-weighted imaging. New identified by enhancement gadolinium (Gd).Forty as areas signal increase on Gd-enhanced scans. Up to 3 before lesion appearance, in future Gd was not detectably different from normal-appearing white matter....
Objective To analyze the texture of T2‐weighted magnetic resonance imaging (MRI) postmortem multiple sclerosis (MS) brain, and to determine whether how MRI correlates with tissue pathology. Methods Ten brain samples from 3 subjects MS were examined. Areas complete, partial, or no loss Luxol fast blue (myelin) Bielschowsky (axons) staining marked on histological images, matched corresponding as lesions, diffusely abnormal white matter (DAWM), normal‐appearing (NAWM). The number CD45 + cells...