A5022026185- Pain Mechanisms and Treatments
- Multiple Sclerosis Research Studies
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Pain Management and Placebo Effect
- Musculoskeletal pain and rehabilitation
- Peripheral Neuropathies and Disorders
- Botulinum Toxin and Related Neurological Disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Acupuncture Treatment Research Studies
- Heart Rate Variability and Autonomic Control
- Neural dynamics and brain function
- Systemic Lupus Erythematosus Research
- Transcranial Magnetic Stimulation Studies
- Migraine and Headache Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Ocular Diseases and Behçet’s Syndrome
- Psychosomatic Disorders and Their Treatments
- Mindfulness and Compassion Interventions
- EEG and Brain-Computer Interfaces
- Pain Management and Treatment
- Nostalgia and Consumer Behavior
- Mental Health Treatment and Access
- Death Anxiety and Social Exclusion
University of Chinese Academy of Sciences
2017-2025
Institute of Psychology, Chinese Academy of Sciences
2016-2025
University of Oxford
2014-2024
Wellcome Centre for Integrative Neuroimaging
2014-2024
Chinese Academy of Sciences
2016-2023
Czech Academy of Sciences, Institute of Psychology
2021-2023
Jingdong (China)
2023
John Radcliffe Hospital
2012-2022
Oxford University Hospitals NHS Trust
2015-2016
Novem (Netherlands)
2015
<h3>Importance</h3> Neuromyelitis optica spectrum disorders (NMOSD) can present with very similar clinical features to multiple sclerosis (MS), but the international diagnostic imaging criteria for MS are not necessarily helpful in distinguishing these two diseases. <h3>Objective</h3> This multicentre study tested previously reported of '(1) at least 1 lesion adjacent body lateral ventricle and inferior temporal lobe; or (2) presence a subcortical U-fibre (3) Dawson9s finger-type lesion' an...
Variability in opioid analgesia has been attributed to many factors. For example, genetic variability of the μ-opioid receptor (MOR)-encoding gene introduces MOR function and endogenous neurotransmission. Emerging evidence suggests that personality trait related experience reward is linked We hypothesized opioid-induced behavioral would be predicted by responsiveness (RWR) response brain circuitry noxious stimuli at baseline before administration. In healthy volunteers using functional...
Pain inhibition by additional somatosensory input is the rationale for widespread use of Transcutaneous Electrical Nerve Stimulation (TENS) to relieve pain. Two main types TENS produce analgesia in animal models: high-frequency (∼50–100 Hz) and low-intensity 'conventional' TENS, low-frequency (∼2–4 high-intensity 'acupuncture-like' TENS. However, efficacy human participants debated, raising question whether analgesic mechanisms identified models are valid humans. Here, we used a...
Significance The human brain displays an enormous amount of intrinsic activity in the absence any task or external stimulation. Here we demonstrate that spinal cord, brain’s principal interface with body, also shows such resting-state activity. We observed biologically plausible and spatially distinct networks reflect functional organisation cord: anterior part likely relating to motor function posterior reflecting sensory function. These were grouped along consistent output to, input from,...
The study of spontaneous fluctuations in the blood-oxygen-level-dependent (BOLD) signal has recently been extended from brain to spinal cord. Two ultra-high field functional magnetic resonance imaging (fMRI) studies humans have provided evidence for reproducible resting-state connectivity between dorsal horns as well ventral horns, and a non-human primates shown that these signals are impacted by cord injury. As were carried out at strengths using region-of-interest (ROI) based analyses, we...
Abstract Spinal cord involvement is a hallmark feature of multiple sclerosis, neuromyelitis optica with AQP4 antibodies and MOG-antibody disease. In this cross-sectional study we use quantitative spinal MRI to better understand these conditions, differentiate them associate relevant clinical outcomes. Eighty participants (20 in each disease group 20 matched healthy volunteers) underwent (cervical cord: 3D T1, T2, diffusion tensor imaging magnetization transfer ratio; thoracic T2), together...
Abstract In a companion paper by Cohen-Adad et al . we introduce the spine generic quantitative MRI protocol that provides valuable metrics for assessing spinal cord macrostructural and microstructural integrity. This was used to acquire single subject dataset across 19 centers multi-subject 42 (for total of 260 participants), spanning three main manufacturers: GE, Philips Siemens. Both datasets are publicly available via git-annex. Data were analysed using Spinal Cord Toolbox produce...
Abstract Background Pain sensitivity varies across multimodal somatosensory stimuli that can rely on different conductive fibres, which, when damaged, will lead to neuropathies. However, there is limited research examining the characteristics of perceived pain, particularly as affected by ageing process, induced various may small or large fibres. Methods Using heat and pressure fibres separately both younger older adults, this study examined age-associated changes in pain perception...
Postherpetic Neuralgia (PHN), develops after the resolution of herpes zoster mucocutaneous eruption, is a debilitating chronic pain. However, there lack knowledge regarding underlying mechanisms associated with ascending and descending pain modulations in PHN patients. Here, we combined psychophysics structural functional magnetic resonance imaging (MRI) techniques to investigate brain alternations Psychophysical tests showed that compared healthy controls, patients had increased state trait...
Chronic pain is thought to arise because of maladaptive changes occurring within the peripheral nervous system and CNS. The transition from acute chronic known involve spinal cord (Woolf Salter, 2000). Therefore, investigate altered human function translate results obtained other species, a noninvasive neuroimaging technique desirable. We have investigated functional response in cervical 18 healthy subjects (aged 22–40 years) noxious thermal non-noxious tactile stimulation left right...
Attrition rates of new analgesics during drug development are high; poor assay sensitivity with reliance on subjective outcome measures being a crucial factor.
Chronic, intractable neuropathic pain is a common and debilitating consequence of neuromyelitis optica spectrum disorder (NMOSD) myelitis, with no satisfactory treatment; few studies have yet to explore its aetiology.To establish if myelitis-associated chronic in NMOSD related the craniocaudal location spinal cord lesions.(1) Retrospective cohort 76 aquaporin 4-antibody (AQP4-Ab)-positive patients from Oxford Liverpool's national clinics, assessing current lesion contemporary onset. (2)...
People often experience two types of pain: social pain and physical pain. The former is related to psychological distance from other people or groups, whereas the latter associated with actual potential tissue damage. Social caused by interpersonal interactions causes negative feelings in individuals has consequences same degree as Various studies have shown an interaction between pain, not only behavioral performance but also activities within shared neural regions. Accordingly, present...
Abstract Studies on functional and structural changes in the primary somatosensory cortex (S1) have provided important insights into neural mechanisms underlying several chronic pain conditions. However, role of S1 plasticity postherpetic neuralgia (PHN) remains elusive. Combining psychophysics magnetic resonance imaging (MRI), we investigated whether PHN patients is linked to reorganization as compared with healthy controls. Results from voxel‐based morphometry showed no differences between...
Abstract Clinical research emphasizes the implementation of rigorous and reproducible study designs that rely on between-group matching or controlling for sources biological variation such as subject’s sex age. However, corrections body size (i.e. height weight) are mostly lacking in clinical neuroimaging designs. This investigates importance parameters their relationship with spinal cord (SC) brain magnetic resonance imaging (MRI) metrics. Data were derived from a cosmopolitan population...
The perception of pain changes as people age. However, how aging affects the quality and whether specific pain-processing brain regions mediate this effect is unclear. We hypothesized that structures in cerebral nociceptive system on variation different psychophysical measures. examined relationships between painful heat stimulation to foot both functional magnetic resonance imaging signals gray matter volume 23 healthy subjects (aged 25∼71 years). Increased age was related decreased...
To convert a painful stimulus into briefly maintainable construct when the is no longer accessible essential to guide human behavior and avoid dangerous situations. Because of aversive nature pain, this encoding process might be influenced by emotional aspects could thus vary across individuals, but we have yet understand both basic underlying neural mechanisms as well potential interindividual differences. Using fMRI in combination with delayed-discrimination task healthy volunteers sexes,...