A5046900065- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Pain Management and Placebo Effect
- Functional Brain Connectivity Studies
- Pain Mechanisms and Treatments
- EEG and Brain-Computer Interfaces
- Medical Imaging and Analysis
- Neural and Behavioral Psychology Studies
- Muscle activation and electromyography studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Engineering and Technology Innovations
- Musculoskeletal pain and rehabilitation
- Atomic and Subatomic Physics Research
- Spinal Cord Injury Research
- Pediatric Pain Management Techniques
- Psychosomatic Disorders and Their Treatments
- Music Therapy and Health
- Heart Rate Variability and Autonomic Control
- Transcranial Magnetic Stimulation Studies
- Neuroscience, Education and Cognitive Function
- MRI in cancer diagnosis
- Multisensory perception and integration
- Data Analysis with R
Max Planck Institute for Human Cognitive and Brain Sciences
2017-2025
University of Oxford
2013-2024
Wellcome Centre for Integrative Neuroimaging
2013-2024
John Radcliffe Hospital
2018-2021
Max Planck Society
2017-2020
University Medical Center Hamburg-Eppendorf
2008-2014
Universität Hamburg
2008-2014
University of Tübingen
2006-2011
Wellcome Centre for Human Neuroimaging
2008
Max Planck Institute for Biological Cybernetics
2008
Placebo analgesia is a prime example of the impact that psychological factors have on pain perception. We used functional magnetic resonance imaging human spinal cord to test hypothesis placebo results in reduction nociceptive processing cord. In line with behavioral data show decreased responses under placebo, pain-related activity strongly reduced placebo. These provide direct evidence for inhibition as one mechanism and highlight can act earliest stages central nervous system.
Abstract The capacity to voluntarily regulate emotions is critical for mental health, especially when coping with aversive events. Several neuroimaging studies of emotion regulation found the amygdala be a target downregulation and prefrontal regions associated downregulation. To characterize role in bidirectional investigate regulatory influences on activity peripheral physiological measures, functional magnetic resonance imaging (fMRI) study simultaneous recording self‐report, startle...
Several lines of evidence suggest a major role the trigeminovascular system in pathogenesis migraine. Using functional magnetic resonance imaging (fMRI), we compared brain responses during trigeminal pain processing migraine patients with those healthy control subjects. The main finding is that activity spinal nuclei response to nociceptive stimulation showed cycling behavior over interval. Although interictal (i.e., outside attack) revealed lower activations controls, preictal shortly...
The computational principles by which the brain creates a painful experience from nociception are still unknown. Classic theories suggest that cortical regions either reflect stimulus intensity or additive effects of and expectations, respectively. By contrast, predictive coding provide unified framework explaining how perception is shaped integration beliefs about world with mismatches resulting comparison these against sensory input. Using functional magnetic resonance imaging during...
Blind individuals have to rely on nonvisual information a greater extent than sighted efficiently interact with the environment, and consequently exhibit superior skills in their spared modalities. These performance advantages are often paralleled by responses occipital cortex, which been suggested be essential for processing blind. However, it is currently unclear through pathways (i.e., thalamocortical or corticocortical connections) reaches cortex of Here, we used functional magnetic...
Significance The human brain displays an enormous amount of intrinsic activity in the absence any task or external stimulation. Here we demonstrate that spinal cord, brain’s principal interface with body, also shows such resting-state activity. We observed biologically plausible and spatially distinct networks reflect functional organisation cord: anterior part likely relating to motor function posterior reflecting sensory function. These were grouped along consistent output to, input from,...
Rationale: Dyspnea is the impairing cardinal symptom of asthma but its accurate perception also crucial for timely initiation treatment. However, underlying brain mechanisms perceived dyspnea in patients with are unknown.Objectives: To study asthma.Methods: By using functional magnetic resonance imaging we compared neuronal responses to experimentally induced and healthy controls. These activations were evoked by pain generalization processes another, similarly unpleasant, physiological...
The endogenous opioid system is involved in fear learning rodents, as agonists attenuate and antagonists facilitate the acquisition of conditioned fear. It has been suggested that an opioidergic signal, which engaged through conditioning acts inhibitory on unconditioned stimulus input, source these effects. To clarify whether blockade neurotransmission enhances humans, to elucidate neural underpinnings such effect, we used functional magnetic resonance imaging combination with behavioral...
The study of spontaneous fluctuations in the blood-oxygen-level-dependent (BOLD) signal has recently been extended from brain to spinal cord. Two ultra-high field functional magnetic resonance imaging (fMRI) studies humans have provided evidence for reproducible resting-state connectivity between dorsal horns as well ventral horns, and a non-human primates shown that these signals are impacted by cord injury. As were carried out at strengths using region-of-interest (ROI) based analyses, we...
Abstract In a companion paper by Cohen-Adad et al . we introduce the spine generic quantitative MRI protocol that provides valuable metrics for assessing spinal cord macrostructural and microstructural integrity. This was used to acquire single subject dataset across 19 centers multi-subject 42 (for total of 260 participants), spanning three main manufacturers: GE, Philips Siemens. Both datasets are publicly available via git-annex. Data were analysed using Spinal Cord Toolbox produce...
With the advent of studies showing that amygdala responses are not limited to fear-related or highly unpleasant stimuli, began focus on stimulus valence and stimulus-related arousal as predictors activity. Recent in chemosensory domain found activity increase with intensity negative positive stimuli. This has led proposal might be an indicator emotional arousal, at least domain. The present study investigated response visual auditory By selecting stimuli based individual ratings, we were...
The perception of pain is shaped by somatosensory information about threat. However, also influenced an individual's expectations. Such expectations can result in clinically relevant modulations and abnormalities pain. In the brain, sensory information, (predictions), discrepancies thereof (prediction errors) are signaled extended network brain areas which generate evoked potentials oscillatory responses at different latencies frequencies. a comprehensive picture how signal predictions,...
The investigation of spontaneous fluctuations the blood-oxygen-level-dependent (BOLD) signal has recently been extended from brain to spinal cord, where it stimulated interest a clinical perspective. A number resting-state functional magnetic resonance imaging (fMRI) studies have demonstrated robust connectivity between time series BOLD in bilateral dorsal horns and those ventral horns, line with neuroanatomy cord. necessary step prior extension is assessing reliability such signals, which...
Abstract Functional magnetic resonance imaging (fMRI) of the spinal cord is relevant for studying sensation, movement, and autonomic function. Preprocessing fMRI data involves segmentation on gradient-echo echo planar (EPI) images. Current automated methods do not work well these data, due to low spatial resolution, susceptibility artifacts causing distortions signal drop-out, ghosting, motion-related artifacts. Consequently, this task demands a considerable amount manual effort which takes...
The depth within the body, small diameter, long length, and varying tissue surrounding spinal cord impose specific considerations when designing radiofrequency coils. optimal coil configuration for 7 T cervical MRI is unknown and, currently, there are very few options. purpose of this work was (1) to establish a quality control protocol evaluating coils (2) use that evaluate performance 4 different designs. Three healthy volunteers custom anthropomorphic phantom (the traveling spines cohort)...
<title>Abstract</title> Temperature perception differs between the two biological sexes male and female with lower thermal detection thresholds found in women compared to men. However, underlying mechanisms of these differences influences sex hormones are not yet sufficiently understood. To assess effects on temperature perception, we measured pain quantitative sensory testing subjective sensation transgender patients undergoing gender-affirming hormone therapy (GAHT). We included 12 trans...
Abstract Clinical research emphasizes the implementation of rigorous and reproducible study designs that rely on between-group matching or controlling for sources biological variation such as subject’s sex age. However, corrections body size (i.e. height weight) are mostly lacking in clinical neuroimaging designs. This investigates importance parameters their relationship with spinal cord (SC) brain magnetic resonance imaging (MRI) metrics. Data were derived from a cosmopolitan population...