A5088651783- Pain Mechanisms and Treatments
- Pain Management and Placebo Effect
- Musculoskeletal pain and rehabilitation
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Functional Brain Connectivity Studies
- Pediatric Pain Management Techniques
- Memory and Neural Mechanisms
- Mental Health Research Topics
- Memory Processes and Influences
- Neural and Behavioral Psychology Studies
- Neural dynamics and brain function
- Deception detection and forensic psychology
- Stress Responses and Cortisol
- Phonetics and Phonology Research
- Neurobiology of Language and Bilingualism
- Reading and Literacy Development
Nathan Kline Institute for Psychiatric Research
2016
University Medical Center Hamburg-Eppendorf
2005-2010
Universität Hamburg
2005-2010
Placebo analgesia is one of the most striking examples cognitive modulation pain perception and underlying mechanisms are finally beginning to be understood. According pharmacological studies, endogenous opioid system essential for placebo analgesia. Recent functional imaging data provides evidence that rostral anterior cingulate cortex (rACC) represents a crucial cortical area this type control. We therefore hypothesized recruits other brain areas outside rACC interactions with these...
The perception of pain results from an interaction between nociceptive and antinociceptive mechanisms. A better understanding the neural circuitry underlying these physiological interactions provides important opportunity to develop treatment strategies for ultimately even prevent pain. Here, we investigated how repeated painful stimulation over several days is processed, perceived finally modulated in healthy human brain. Twenty subjects were stimulated daily with a 20min paradigm 8...
The endogenous opioid system is involved in fear learning rodents, as agonists attenuate and antagonists facilitate the acquisition of conditioned fear. It has been suggested that an opioidergic signal, which engaged through conditioning acts inhibitory on unconditioned stimulus input, source these effects. To clarify whether blockade neurotransmission enhances humans, to elucidate neural underpinnings such effect, we used functional magnetic resonance imaging combination with behavioral...
Habituation to repetitive painful stimulation may represent an important protection mechanism against the development of chronic pain states. However, exact neurobiological mechanisms this phenomenon remain unclear. In study we (i) explore somatotopic specificity attenuation over time and (ii) investigate role endogenous opioid system in its development. We investigated 24 healthy volunteers with a paradigm daily left volar forearm for 1 week. was assessed by comparing pain-related responses...
Human behavior can be influenced by information that is not consciously perceived. Recent behavioral and electrophysiological evidence suggests, however, the processing of subliminal stimuli completely beyond an observer's conscious control. The present study aimed to characterize cortical network implements strategic control over interfering at multiple stages. Fourteen participants underwent functional magnetic resonance imaging (fMRI) scanning while performing a metacontrast masking...
The endogenous opioid system represents one of the principal systems in modulation pain. This has been demonstrated studies placebo analgesia and stress-induced analgesia, where anti-nociceptive activity triggered by pain itself or cognitive states is blocked antagonists. aim this study was to characterize effect receptor blockade on physiological processing painful thermal stimulation absence manipulation. We therefore measured BOLD (blood oxygen level dependent) signal responses intensity...
Abstract This data descriptor describes a repository of openly shared from an experiment to assess inter-individual differences in default mode network (DMN) activity. includes cross-sectional functional magnetic resonance imaging (fMRI) the Multi Source Interference Task, DMN deactivation, Moral Dilemma activation, resting state fMRI scan, and neurofeedback paradigm, modulation, along with accompanying behavioral cognitive measures. We report technical validation n=125 participants final...