A5046530468- Advanced Neuroimaging Techniques and Applications
- Multiple Sclerosis Research Studies
- Cerebrovascular and Carotid Artery Diseases
- Olfactory and Sensory Function Studies
- Advanced MRI Techniques and Applications
- Advanced Chemical Sensor Technologies
- Acute Ischemic Stroke Management
- Biochemical Analysis and Sensing Techniques
- Cardiovascular Health and Disease Prevention
- Ultrasound Imaging and Elastography
- MRI in cancer diagnosis
- RNA regulation and disease
- Otolaryngology and Infectious Diseases
- Immunotherapy and Immune Responses
- Alzheimer's disease research and treatments
- Renal and Vascular Pathologies
- Ultrasound and Hyperthermia Applications
- Prion Diseases and Protein Misfolding
- Peripheral Neuropathies and Disorders
- Radiomics and Machine Learning in Medical Imaging
- Systemic Lupus Erythematosus Research
- Intracranial Aneurysms: Treatment and Complications
- Medical Imaging and Analysis
- Vestibular and auditory disorders
- Polyomavirus and related diseases
Technische Universität Dresden
2015-2025
University Hospital Carl Gustav Carus
2016-2025
Carl Gustav Carus-Institut
2017-2024
Klinik und Poliklinik für Psychotherapie und Psychosomatik
2017
University of Hagen
2016-2017
Western University
2009-2012
Humboldt-Universität zu Berlin
2004
Charité - Universitätsmedizin Berlin
2004
Friedrich Baur Stiftung
1999
<h3>Objective</h3> To evaluate individual neurofilament light chain (NfL) variation over the time of disease course and potential NfL measurement to predict treatment response in patients with MS. <h3>Methods</h3> We investigated 15 MS after immune reconstitution alemtuzumab (ATZ). Monthly serum (sNFL) measurements were correlated Expanded Disability Status Scale (EDSS), MRI, relapse activity an observational period up 102 months. <h3>Results</h3> Before ATZ, sNfL was significantly increased...
Background: Multiple Sclerosis Partners Advancing Technology and Health Solutions (MS PATHS) is the first example of a learning health system in multiple sclerosis (MS). Methods: MS PATHS being conducted ten healthcare institutions three countries, each contributing standardized information acquired during routine care. Institutional participation required following: active patient census ≥500; at least one Siemens 3T magnetic resonance imaging scanner; willingness to standardize...
The quantification of new or enlarged lesions from follow-up MRI scans is an important surrogate clinical disease activity in patients with multiple sclerosis (MS). Not only manual segmentation time consuming, but inter-rater variability high. Currently, a few fully automated methods are available. We address this gap the field by employing 3D convolutional neural network (CNN) encoder-decoder architecture for automatic longitudinal lesion segmentation. Input data consist two fluid...
Abstract In a companion paper by Cohen-Adad et al . we introduce the spine generic quantitative MRI protocol that provides valuable metrics for assessing spinal cord macrostructural and microstructural integrity. This was used to acquire single subject dataset across 19 centers multi-subject 42 (for total of 260 participants), spanning three main manufacturers: GE, Philips Siemens. Both datasets are publicly available via git-annex. Data were analysed using Spinal Cord Toolbox produce...
Removal of the olfactory bulb (OB) leads to depression like behavior in rodents. A link between and function is also established humans. We hypothesized that human OB volume relates depressive state tested whether such a potential coherence moderated by structural alterations other brain regions.Eighty-three participants (32 patients with major 51 matched healthy controls) underwent MR scanning. Individual volumes were compared controls impact comorbidity was analyzed multiple regression...
To develop an automatic method for accurate and robust thalamus segmentation in T1w-MRI widespread clinical use without the need strict harmonization of acquisition protocols and/or scanner-specific normal databases.A three-dimensional convolutional neural network (3D-CNN) was trained on 1975 T1w volumes from 170 MRI scanners using masks generated with FSL-FIRST as ground truth. Accuracy evaluated 18 manually labeled expert masks. Intra- inter-scanner test-retest stability were assessed 477...
Abstract Clinical research emphasizes the implementation of rigorous and reproducible study designs that rely on between-group matching or controlling for sources biological variation such as subject’s sex age. However, corrections body size (i.e. height weight) are mostly lacking in clinical neuroimaging designs. This investigates importance parameters their relationship with spinal cord (SC) brain magnetic resonance imaging (MRI) metrics. Data were derived from a cosmopolitan population...
OBJECTIVE The depiction of cranial nerves (CNs) using diffusion tensor imaging (DTI) is great interest in skull base tumor surgery and DTI used with deterministic tracking methods has been reported previously. However, there are still no good usable for the elimination noise from resulting depictions. authors have hypothesized that probabilistic could lead to more accurate results, because it efficiently extracts information underlying data. Moreover, adapted a previously described technique...
Wilson's disease is a rare autosomal recessive disorder characterized by the accumulation of copper, mainly in liver and brain. As copper brain leads to disturbances basal ganglia function, neurological-type patients typically present with hypo- hyperkinetic extrapyramidal symptoms, Parkinsonism being very common. Although there are numerous reports on olfactory deficits primary neurodegenerative disorders, function has not been investigated metabolic disorders presenting features....
Magnetic resonance imaging (MRI) is used to follow-up multiple sclerosis (MS) and evaluate disease progression therapy response via lesion quantification. However, there a lack of automated post-processing techniques quantify individual MS change. The present study developed secondary algorithm for segmentation routine changes in volume over time. An Automatic Follow-up Individual Lesions (AFIL) was process time series pre-segmented binary masks. resulting consistently labelled masks allowed...
In spite of marked disability, patients with primary progressive multiple sclerosis (PPMS) display smaller lesion volumes on conventional magnetic resonance imaging (MRI) compared other forms (MS). Hence, damage to the normal-appear ing brain tissue (NA BT) may play an important role in explaining patho genesis disability PPMS. Diffusion-weighted MRI (DW-MRI) probes water diffusion vivo that can be altered by logic changes. Using DW-MRI we investigated NA BT 15 PPMS over one year. The...
Abstract Purpose Clinically successful endovascular therapy ( EVT ) in ischemic stroke requires reliable noninvasive pretherapeutic selection criteria. We investigated the association of imaging parameters including CT angiographic collaterals and degree reperfusion with clinical outcome after . Methods In our database, we identified 93 patients large vessel occlusion anterior circulation treated Besides data, assessed baseline Alberta Stroke Program Early score ASPECTS on noncontrast NCCT...
Background In cases of suspected mastoiditis, imaging is used to evaluate the extent mastoid destruction and possible complications. The role magnetic resonance (MRI) in mastoiditis has not been systematically evaluated. Purpose To assess diagnostic performance MRI patients with acute mastoiditis. Material Methods Twenty-three were included this retrospective study (15 boys, 8 girls; mean age, 2 years 11 months). All examined on a 1.5 T system. examination both enhanced non-enhanced turbo...
The insular cortex plays a key role in the integration of multimodal information and interoceptive exteroceptive processing. For instance, neurons central dorsal insula that are active during tasks, also show an adaptation to gustatory stimulation. We tested link between interoception exteroception for olfactory system (i.e., second domain chemosensation). In sample 31 participants, function was assessed two dimensional approach while Heartbeat Perception Task served as measurement cardiac...
The human sense of smell is highly individual and characterized by a strong variability in the perception evaluation olfactory stimuli, depending on cultural imprint current physiological conditions. Since this perspective has often been neglected fMRI studies hedonic coding, study focuses neuronal activity connectivity patterns resulting from subject-specific stimulation.Thirty-one normosmic participants took part block designed paradigm consisting three stimulation sessions. most pleasant...
Abstract Removing function from a developed and functional sensory system is known to alter both cerebral morphology connections. To date, majority of studies assessing sensory-dependent plasticity have focused on effects either early onset or long-term loss little how the recent affects human brain. With aim determining connectivity, we assessed differences between individuals with acquired olfactory (duration 7–36 months) matched healthy controls in their grey matter volume, using...