A5093827682- Advanced Neuroimaging Techniques and Applications
- Spinal Cord Injury Research
- Advanced MRI Techniques and Applications
- Traumatic Brain Injury Research
- Spinal Dysraphism and Malformations
- Cervical and Thoracic Myelopathy
- Peripheral Nerve Disorders
Universitätsklinik Balgrist
2024-2025
University of Zurich
2024-2025
Abstract Functional magnetic resonance imaging (fMRI) of the spinal cord is relevant for studying sensation, movement, and autonomic function. Preprocessing fMRI data involves segmentation on gradient-echo echo planar (EPI) images. Current automated methods do not work well these data, due to low spatial resolution, susceptibility artifacts causing distortions signal drop-out, ghosting, motion-related artifacts. Consequently, this task demands a considerable amount manual effort which takes...
Abstract Objective To characterize structural integrity of the lumbosacral enlargement and conus medullaris within one month after spinal cord injury (SCI). Methods Lumbosacral MRI data were acquired in patients with sudden onset (<7 days) SCI at cervical or thoracic level approximately healthy controls. Tissue loss evaluated through diffusion tensor (DTI) T2*‐weighted imaging (cross‐sectional area [CSA] measurements). Associations degree neurological impairment assessed using linear...
Abstract Blood-oxygen-level dependent (BOLD) functional magnetic resonance imaging (fMRI) can be used to map neuronal function in the cervical cord, yet conclusive evidence supporting its applicability lumbosacral cord is still lacking. This study aimed (i) demonstrate feasibility of BOLD fMRI mapping activation during a unilateral lower extremity motor task and (ii) investigate impact echo time (TE) on effect size. Twelve healthy volunteers underwent using four reduced-field-of-view...
Abstract Blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) can be used to map neuronal function in the cervical cord, yet conclusive evidence supporting its applicability lumbosacral cord is still lacking. This study aimed (i) demonstrate feasibility of BOLD fMRI for indirectly mapping neural activity during a unilateral lower extremity motor task and (ii) investigate impact echo time (TE) on effect size. Twelve healthy volunteers underwent using four reduced...
MRI has been widely used to investigate the structural damage after traumatic spinal cord injury (SCI). While most small animal studies have focused on site, remote SCI-related along neuraxis received less attention. Here, we demonstrate that ex vivo diffusion and cross-sectional area measurements are sensitive neurodegeneration in a rat contusion SCI model, showing gray matter dorsal column atrophy alongside decreased fractional anisotropy columns several levels rostral epicenter. Imaging...